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Reelin and Thyroid Hormone

  • Manuel Álvarez-Dolado

Thyroid hormone [3,5,3′-triiodothyronine (T3) and thyroxine (T4)] is essential for proper brain development. In humans, the lack of adequate T3 levels during the perinatal period leads to cretinism, a syndrome associated with mental retardation and neurological deficits, such as ataxia, spasticity, and deafness (for review, see Legrand, 1984; Dussault and Ruel, 1987; Braverman and Utiger, 2000; Bernal, 2005a). These alterations are due to misregulation of the gene expression controlled by T3 through its interaction with nuclear receptors, which act as ligand-modulated transcription factors (Muñoz and Bernal, 1997; Forrest and Vennström, 2000; Yen et al., 2006).

Keywords

Thyroid Hormone Olfactory Bulb Iodine Deficiency Granule Cell Layer Thyroid Hormone Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Manuel Álvarez-Dolado
    • 1
  1. 1.Cellular Regeneration LaboratoryCentra de Investigatión Principe Felipe (CIPF)ValenciaSpain

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