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Analyzing DNA-Protein Interactions on a Chip

  • Limin Lin
  • James P. Brody
Part of the Biotechnology Intelligence Unit book series (BIOIU)

Abstract

Gene expression is regulated by multi-protein complexes binding to short noncoding regions of genomic DNA, called cis-regulatory elements. A long-term goal of genomics is to identify and annotate all essential elements of the genome. Most coding elements of the genome have been identified and annotated; however, most regulatory elements have not. This chapter describes a method for the high throughput identification of DNA-protein interactions to identify cis-regulatory elements.

Keywords

Surface Plasmon Resonance Single Base Pair Surface Plasmon Resonance Imager Surface Plasmon Resonance Angle Surface Plasmon Resonance Signal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringUniversity of CaliforniaIrvineUSA

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