Genetic Risks in Schizophrenia: Cross-National Prospective Longitudinal High-Risk Studies

  • Judith G. Auerbach
  • L. Erlenmeyer-Kimling
  • Barbara Fish
  • Sydney L. Hans
  • Loring J. Ingraham
  • Joseph Marcus
  • Thomas F. McNeil
  • Erland Schubert

Prospective longitudinal studies are a powerful means to identify the causal chains of biological and environmental factors that underlie the development of serious mental disorders. Schizophrenia is one of these disorders. Schizophrenia is a multifactorial neurodevelopmental disorder whose specific molecular genetic, epigenetic, stochastic, and environmental bases remain elusive. The chronic debilitating nature of the disorder places a heavy emotional and financial burden on the individual, family, and society. Although the lifetime prevalence of schizophrenia is 1% in the general population that has passed through the risk period, it accounts for up to 3% of total national health-care expenditures in Western countries (). The hypothetical ability to intervene in the developmental progression of the disorder at a point before breakdown is contingent upon the elucidation of early behavioral and other markers of genetic liability to the disorder and their triggers. In this chapter, we focus on research aimed at early detection of markers that may predict to the later onset of schizophrenia. Once these markers are identified, intervention can, at least in principle, be targeted to those individuals most at risk for the disorder.


Neurological Soft Sign Genetic Liability Schizophrenia Research Schizotypal Personality Disorder Parental Mental Illness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Judith G. Auerbach
    • 1
    • 2
  • L. Erlenmeyer-Kimling
    • 3
    • 4
  • Barbara Fish
    • 5
  • Sydney L. Hans
    • 6
  • Loring J. Ingraham
    • 7
  • Joseph Marcus
    • 8
  • Thomas F. McNeil
    • 9
  • Erland Schubert
    • 9
  1. 1.Department of PsychologyBen-Gurion UniversityBeer-ShevaIsrael
  2. 2.Center for Advanced StudiesNorwegian Academy of Science and LettersOsloNorway
  3. 3.Departments of Medical GeneticsNew York State Psychiatric InstituteNew YorkUSA
  4. 4.Departments of Psychiatry and of Genetics and DevelopmentColumbia UniversityNew YorkUSA
  5. 5.Department of Psychiatry and Behavioral SciencesUniversity of CaliforniaLos AngelesUSA
  6. 6.School of Social Service AdministrationUniversity of ChicagoChicagoUSA
  7. 7.Department of PsychologyThe George Washington UniversityWashingtonUSA
  8. 8.Department of PsychiatryUniversity of ChicagoChicagoUSA
  9. 9.Department of Psychiatric EpidemiologyUniversity Hospital, Lund UniversityIsrael

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