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Genetic Analysis of Conduct Disorder and Antisocial Behavior

  • Soo Hyun Rhee
  • Irwin D. Waldman

In this chapter, we examine the evidence for genetic influences on conduct disorder and antisocial behavior. First, we present results from a meta-analysis of twin and adoption studies estimating the relative magnitude of genetic and environmental influences on antisocial behavior (Rhee & Waldman, 2002). Second, we discuss recent studies that have examined several interesting issues in the etiology of antisocial behavior, including genotype × environment interactions, co-occurrence with other psychiatric disorders, the etiology of psychopathy, and the etiology of adolescent-limited versus life-course-persistent antisocial behavior. Third, we review association studies examining the influence of specific candidate genes on antisocial behavior and linkage studies conducting genome-wide screens for quantitative trait loci (QTLs) influencing antisocial behavior.

Keywords

Antisocial Behavior Twin Study Conduct Disorder A218C Polymorphism Adoption Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Achenbach, T. M.,&Edelbrock, C. S. (1983). Manual for the Child Behavior Checklist and Revised Behavior Profile. Burlington, VT: University of Vermont.Google Scholar
  2. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.Google Scholar
  3. Angold, A,&Costello, E. J. (1993). Depressive comorbidity in children and adolescents: Empirical, theoretical and methodological issues. American Journal of Psychiatry, 150, 1779–1791.PubMedGoogle Scholar
  4. Arseneault, L., Moffitt, T. E., Caspi, A., Taylor, A., Rijsdijk, F. V., Jaffee, S. R., et al. (2003). Strong genetic effects on cross-situational antisocial behaviour among 5-year-old children according to mothers, teachers, examiner-observers, and twins’ self-reports. Journal of Child Psychology and Psychiatry, 44, 832–848.PubMedGoogle Scholar
  5. Baca-Garcia, E., Vaquero, C., Diaz-Sastre, C., Garcìa-Resa, E., Saiz-Ruiz, J., Fernàndez-Piqueras, J., et al. (2004). Lack of association between the serotonin transporter promoter gene polymorphism and impulsivity or aggressive behavior among suicide attempters and healthy volunteers. Psychiatry Research, 126, 99–106.PubMedGoogle Scholar
  6. * Baker, L., Mack, W., Moffitt, T.,&Mednick, S. (1989). Sex differences in property crime in a Danish adoption cohort. Behavior Genetics, 19, 355–370.PubMedGoogle Scholar
  7. Beitchman, J. H., Baldassarra, L., Mik, H., De Luca, V., King, N., Bender, D., et al. (2006). Serotonin transporter polymorphisms and persistent, pervasive childhood aggression. American Journal of Psychiatry, 163, 1103–1105.Google Scholar
  8. Biederman, J., Newcorn, J.,&Sprich, S. (1991). Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. American Journal of Psychiatry, 148, 564–577.PubMedGoogle Scholar
  9. Blair, R. J. R., Peschardt, K. S., Budhani, S., Mitchell, D. G. V.,&Pine, D. S. (2006). The development of psychopathy. Journal of Child Psychology and Psychiatry, 47, 262–275.PubMedGoogle Scholar
  10. * Blanchard, J. M., Vernon, P. A.,&Harris, J. A. (1995). A behavior genetic investigation of multiple dimensions of aggression. Behavior Genetics, 25, 256.Google Scholar
  11. Blonigen, D. M., Carlson, S. R., Krueger, R. F.,&Patrick, C. J. (2003). A twin study of self-reported psychopathic personality traits. Personality and Individual Differences, 35, 179–197.Google Scholar
  12. Blonigen, D. M., Hicks, B. M., Krueger, R. F., Patrick, C. J.,&Iacono, W. G. (2005). Psychopathic personality traits: Heritability and genetic overlap with internalizing and externalizing psychopathology. Psychological Medicine, 35, 637–648.PubMedGoogle Scholar
  13. * Bohman, M. (1978). Some genetic aspects of alcoholism and criminality: A population of adoptees. Archives of General Psychiatry, 35, 269–276.PubMedGoogle Scholar
  14. * Brandon, K,&Rose, R. J. (1995). A multivariate twin family study of the genetic and environmental structure of personality, beliefs, and alcohol use. Behavior Genetics, 25, 257.Google Scholar
  15. Bremner, J. D.,&Vermetten, E. (2001). Stress and development: behavioral and biological consequences. Development and Psychopathology, 13, 473–489.Google Scholar
  16. Brunner, H. G., Nelson, M., Breakefield, X. O., Ropers, H. H.,&van Oost, B. A. (1993). Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase. Science, 262, 578–580.PubMedGoogle Scholar
  17. Brunner, H. G., Nelen, M. R., van Zandvoort, P., Abeling, N. G., van Gennip, A. H., Wolters, E. C., et al. (1993). X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism. American Journal of Human Genetics, 52, 1032–1039.PubMedGoogle Scholar
  18. Burt, S. A., Krueger, R. F., McGue, M.,&Iacono, W. G. (2001). Sources of covariation among attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder: The importance of shared environment. Journal of Abnormal Psychology, 110, 516–525.PubMedGoogle Scholar
  19. Button, T. M. M., Hewitt, J. K., Rhee, S. H., Young, S. E., Corley, R. P.,&Stallings, M. C. (2006). Examination of the causes of covariation between conduct disorder symptoms and vulnerability to drug dependence. Twin Research and Human Genetics, 9, 38–45.PubMedGoogle Scholar
  20. Button, T. M. M., Scourfield, J., Martin, N., Purcell, S.,&McGuffin, P. (2005). Family dysfunction interacts with genes in the causation of antisocial symptoms. Behavior Genetics, 35, 115–120.PubMedGoogle Scholar
  21. Cadoret, R. J., Cain, C. A.,&Crowe, R. R. (1983). Evidence for gene-environment interaction in the development of adolescent antisocial behavior. Behavior Genetics, 13, 301–310.PubMedGoogle Scholar
  22. Cadoret, R. J., Langbehn, D., Caspers, K., Troughton, E. P., Yucuis, R., Sandhu, H. K., et al. (2003). Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Comprehensive Psychiatry, 44, 88–101.PubMedGoogle Scholar
  23. * Cadoret, R. J., Troughton, E., O’Gorman, T. W.,&Heywood, E. (1986). An adoption study of genetic and environmental factors in drug abuse. Archives of General Psychiatry, 43, 1131–1136.PubMedGoogle Scholar
  24. * Cadoret, R. J., Yates, W. R., Troughton, E., Woodworth, G.,&Stewart, M. A. (1995). Adoption study demonstrating two genetic pathways to drug abuse. Archives of General Psychiatry, 52, 42–52.PubMedGoogle Scholar
  25. * Cadoret, R. J., Yates, W. R., Troughton, E., Woodworth, G.,&Stewrat, M. A. (1996). An adoption study of drug abuse/dependency in females. Comprehensive Psychiatry, 37, 88–94.PubMedGoogle Scholar
  26. * Carey, G. (1992). Twin imitation for antisocial behavior: Implications for genetic and family environment research. Journal of Abnormal Psychology, 101, 18–25.PubMedGoogle Scholar
  27. Cases, O., Seif, I., Grimsby, J., Gaspar, P., Chen, K., Pournin, S., et al. (1995). Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science, 268, 1763–1766.PubMedGoogle Scholar
  28. Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., et al. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851–854.PubMedGoogle Scholar
  29. * Cates, D. S., Houston, B. K., Vavak, C. R., Crawford, M. H.,&Uttley, M. (1993). Heritability of hostility-related emotions, attitudes, and behaviors. Journal of Behavioral Medicine, 16, 237–256.PubMedGoogle Scholar
  30. * Centerwall, B. S,&Robinette, C. D. (1989). Twin concordance for dishonorable discharge from the military: With a review of genetics of antisocial behavior. Comprehensive Psychiatry, 30, 442–446.PubMedGoogle Scholar
  31. Cloninger, C. R,&Gottesman, I. I. (1987). Genetic and environmental factors in antisocial behavior disorders. In S. A. Mednick, T. E. Moffitt,&S. A. Stack (Eds.), The causes of crime: New biological approaches (pp. 92–109). New York: Cambridge University Press.Google Scholar
  32. Cloninger, C. R., Sigvardsson, S., Bohman, M.,&von Knorring, A. -L. (1982). Predisposition to petty criminality in Swedish adoptees. II. Cross-fostering analysis of gene-environment interaction. Archives of General Psychiatry, 39, 1242–1247.PubMedGoogle Scholar
  33. Coccaro, E. F., Kavoussi, R. J., Cooper, T. B.,&Hauger, R. L. (1997). Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. American Journal of Psychiatry, 154, 1430–1435.PubMedGoogle Scholar
  34. Coccaro, E. F., Siever, L. J., Klar, H., Rubenstein, K., Benjamin, E.,&Davis, K. L. (1987). Diminished prolactin responses to repeated fenfluramine challenge in man. Psychiatry Research, 22, 257–259.PubMedGoogle Scholar
  35. * Coid, B., Lewis, S. W.,&Reveley, A. M. (1993). A twin study of psychosis and criminality. British Journal of Psychiatry, 162, 87–92.PubMedGoogle Scholar
  36. Cook, E. H., Stein, M. A., Krasowski, M. D., Cox, N. J., Olkon, D. M., Kieffer, J. E., et al. (1995). Association of attention-deficit disorder and the dopamine transporter gene. American Journal of Human Genetics, 56, 993–998.PubMedGoogle Scholar
  37. * Cunningham, L., Cadoret, R. J., Loftus, R.,&Edwards, J. E. (1975). Studies of adoptees from psychiatrically disturbed biological parents: Psychiatric conditions in childhood and adolescence. British Journal of Psychiatry, 126, 534–549.PubMedGoogle Scholar
  38. * Deater-Deckard, K., Reiss, D., Hetherington, E. M.,&Plomin, R. (1997). Dimensions and disorders of adolescent adjustment: A quantitative genetic analysis of unselected samples and selected extremes. Journal of Child Psychology and Psychiatry, 38, 515–525.PubMedGoogle Scholar
  39. Dick, D. M., Li, T.-K., Edenberg, H. J., Hesselbrock, V., Kramer, J., Kuperman, S., et al. (2004). A genome-wide screen for genes influencing conduct disorder. Molecular Psychiatry, 9, 81–86.PubMedGoogle Scholar
  40. Dick, D. M., Viken, R. J., Kaprio, J., Pulkkinen, L.,&Rose, R. J. (2005). Understanding the covariation among childhood externalizing symptoms: Genetic and environmental influences on conduct disorder, attention deficit hyperactivity disorder, and oppositional defiant disorder symptoms. Journal of Abnormal Child Psychology, 33, 219–229.PubMedGoogle Scholar
  41. * DiLalla, D. L., Carey, G., Gottesman, I. I.,&Bouchard, T. J. (1996). Heritability of MMPI personality indicators of psychopathology in twins reared apart. Journal of Abnormal Psychology, 105, 491–499.PubMedGoogle Scholar
  42. DiLalla, L. F,&Gottesman, I. I. (1989). Heterogeneity of causes for delinquency and criminality: Lifespan perspectives. Development and Psychopathology, 1, 339–349.Google Scholar
  43. Dougherty, D., Bonab, A. A., Spencer, T. J., Rauch, S. L., Madras, B. K.,&Fischman, A. J. (1999). Dopamine transporter density in patients with attention deficit hyperactivity disorder. Lancet, 354, 2132–2133.PubMedGoogle Scholar
  44. * Eaves, L. J., Silberg, J. L., Meyer, J. M., Maes, H. H., Simonoff, E., Pickles, A., et al. (1997). Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the Virginia Twin Study of Adolescent Behavioral Development. Journal of Child Psychology and Psychiatry, 38, 965–980.PubMedGoogle Scholar
  45. * Edelbrock, C., Rende, R., Plomin, R.,&Thompson, L. A. (1995). A twin study of competence and problem behavior in childhood and early adolescence. Journal of Child Psychology and Psychiatry, 36, 775–785.PubMedGoogle Scholar
  46. * Eley, T. C., Lichtenstein, P.,&Stevenson, J. (1999). Sex differences in the etiology of aggressive and nonaggressive antisocial behavior: Results from two twin studies. Child Development, 70, 155–168.PubMedGoogle Scholar
  47. Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., et al. (2005). Molecular genetics of attention-deficit/hyperactivity disorder. Biological Psychiatry, 57, 1313–1323.PubMedGoogle Scholar
  48. * Finkel, D,&McGue, M. (1997). Sex differences and nonadditivity in heritability of the multidimensional personality questionnaire scales. Journal of Personality and Social Psychology, 72, 929–938.PubMedGoogle Scholar
  49. Foley, D. L., Eaves, L. J., Wormley, B., Silberg, J. L., Maes, H. H., Kuhn, J., et al. (2004). Childhood adversity, monoamine oxidase A genotype, and risk for conduct disorder. Archives of General Psychiatry, 61, 738–744.PubMedGoogle Scholar
  50. Fulker, D. W., Cherny, S. S., Sham, P. C.,&Hewitt, J. K. (1999). Combined linkage and association sib-pair analysis for quantitative traits. American Journal of Human Genetics, 64, 259–267.PubMedGoogle Scholar
  51. Gelernter, J., Kranzler, H. R., Satel, S.,&Rao, P. A. (1994). Genetic association between dopamine transporter protein alleles and cocaine-induced paranoid. Neuropsychopharmacology, 11, 195–200.PubMedGoogle Scholar
  52. * Ghodsian-Carpey, J.,&Baker, L. A. (1987). Genetic and environmental influences on aggression in 4- to 7-year-old twins. Aggressive Behavior, 13, 173–186.Google Scholar
  53. Giros, B., Jaber, M., Jones, S. R., Wightman, R. M.,&Caron, M. G. (1996). Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature, 379, 606–612.PubMedGoogle Scholar
  54. Gjone, H,&Stevenson, J. (1997). The association between internalizing and externalizing behavior in childhood and early adolescence: Genetic or environmental common influences? Journal of Abnormal Child Psychology, 25, 277–286.PubMedGoogle Scholar
  55. * Gottesman, I. I. (1963). Heritability of personality: A demonstration. Psychological Monographs, 77(9, Whole No. 572).Google Scholar
  56. * Gottesman, I. I. (1965). Personality and natural selection. In S. G. Vandenberg (Ed.), Methods and goals in human behavior genetics (pp. 63–80). New York: Academic Press.Google Scholar
  57. Gough, H. G,&Heilbrun, A. B. (1972). The adjective checklist manual. Palo Alto, CA: Consulting Psychologists Press.Google Scholar
  58. Grove, W. M., Eckert, E. D., Heston, L., Bouchard, T. J., Segal, N.,&Lykken, D. T. (1990). Heritability of substance abuse and antisocial behavior: A study of monozygotic twins reared apart. Biological Psychiatry, 27, 1293–1304.PubMedGoogle Scholar
  59. * Gustavsson, J. P., Pedersen, N. L., Åsberg, M.,&Schalling, D. (1996). Exploration into the sources of individual differences in aggresion-, hostility-, and anger-related (AHA) personality traits. Personality and Individual Differences, 21, 1067–1071.Google Scholar
  60. Haberstick, B. C., Lessem, J. M., Hopfer, C. J., Smolen, A., Ehringer, M. A., Timberlake, D., et al. (2005). Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment. American Journal of Medical Genetics, 135, 59–64.Google Scholar
  61. Haberstick, B. C., Smolen, A.,&Hewitt, J. K. (2006). Family-based association test of the 5HTTLPR and aggressive behavior in a general population sample of children. Biological Psychiatry, 59, 836–843.PubMedGoogle Scholar
  62. Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., et al. (1996). Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry, 66, 2621–2624.PubMedGoogle Scholar
  63. Heinz, A., Jones, D. W., Mazzanti, C., Goldman, D., Ragan, P., Hommer, D., et al. (2000). A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biological Psychiatry, 47, 643–649.PubMedGoogle Scholar
  64. Hennig, J., Reuter, M., Netter, P., Burk, C.,&Landt, O. (2005). Two types of aggression are differentially related to serotonergic activity and the A779C TPH polymorphism. Behavioral Neuroscience, 119, 16–25.PubMedGoogle Scholar
  65. Huang, Y., Cate, S. P., Battistuzi, C., Oquendo, M. A., Brent, D.,&Mann, J. J. (2004). An association between a functional polymorphism in the monoamine oxidase A gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology, 29, 1498–1505.PubMedGoogle Scholar
  66. Huizinga, D., Haberstick, B. C., Smolen, A., Menard, S., Young, S. E., Corley, R. P., et al. (2006). Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype. Biological Psychiatry, 60, 677–683.PubMedGoogle Scholar
  67. Hyde, J. S. (1984). How large are gender differences in aggression? A developmental meta-analysis. Developmental Psychology, 20, 722–736.Google Scholar
  68. Jacobson, K. C., Neale, M. C., Prescott, C. A.,&Kendler, K. S. (2001). Behavioral genetic confirmation of a life-course perspective on antisocial behavior: Can we believe the results? Behavior Genetics, 31, 456.Google Scholar
  69. Jaffee, S. R., Caspi, A., Moffitt, T. E., Dodge, K. A., Rutter, M., Taylor, A., et al. (2005). Nature × nurture: Genetic vulnerabilities interact with physical maltreatment to promote conduct problems. Development and Psychopathology, 17, 67–84.PubMedGoogle Scholar
  70. Jorm, A. F., Prior, M., Sanson, A., Smart, D., Zhang, Y.,&Easteal, S. (2001). Association of a polymorphism of the dopamine transporter gene with externalizing behavior problems and associated temperament traits: A longitudinal study from infancy to the mid-teens. American Journal of Medical Genetics, 105, 346–350.PubMedGoogle Scholar
  71. Kendler, K. S., Prescott, C. A., Myers, J.,&Neale, M. C. (2003). The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Archives of General Psychiatry, 60, 929–937.PubMedGoogle Scholar
  72. Kent, L. (2004). Recent advances in the genetics of attention deficit hyperactivity disorder. Current Psychiatry Reports, 6, 143–148.PubMedGoogle Scholar
  73. Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., et al. (2006). MAOA, maltreatment, and gene-environment interaction predicting children’s mental health: New evidence and a meta-analysis. Molecular Psychiatry, 11, 903–913.PubMedGoogle Scholar
  74. Kruesi, M. J., Rapoport, J. L., Hamburger, S., Hibbs, E., Potter, W., Z., Lenane, M., et al. (1990). Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Archives of General Psychiatry, 55, 989–994.Google Scholar
  75. Kunugi, H., Ishida, S., Kato, T., Sakai, S., Tatsumi, M., Hirose, T., et al. (1999). No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients. American Journal of Psychiatry, 156, 774–776.PubMedGoogle Scholar
  76. Larsson, H., Andershed, H.,&Lichtenstein, P. (2006). A genetic factor explains most of the variation in the psychopathic personality. Journal of Abnormal Psychology, 115, 221–230.PubMedGoogle Scholar
  77. Lidberg, L., Tuck, J. R., Asberg, M., Scalia-Tomba, G. P.,&Bertilsson, L. (1985). Homicide, suicide and CSF 5-HIAA. Acta Psychiatrica Scandinavica, 71, 230–236.PubMedGoogle Scholar
  78. * Livesley, W. J., Jang, K. L., Jackson, D. N.,&Vernon, P. A. (1993). Genetic and environmental contributions to dimensions of personality disorder. American Journal of Psychiatry, 150, 1826–1831.PubMedGoogle Scholar
  79. * Loehlin, J. C.,&Nichols, R. C. (1976). Heredity, environment, and personality. Austin, TX: University of Texas Press.Google Scholar
  80. * Loehlin, J. C., Willerman, L.,&Horn, J. M. (1987). Personality resemblance in adoptive families: A 10-year follow-up. Journal of Personality and Social Psychology, 53, 961–969.Google Scholar
  81. Lykken, D. T. (1997). Incompetent parenting: its causes and cures. Child Psychiatry and Human Development, 27, 129–137.PubMedGoogle Scholar
  82. * Lyons, M. J., True, W. R., Eisen, S. A., Goldberg, J., Meyer, J. M., Faraone, S. V., et al. (1995). Differential heritability of adult and juvenile antisocial traits. Archives of General Psychiatry, 52, 906–915.PubMedGoogle Scholar
  83. * Lytton, H., Watts, D.,&Dunn, B. E. (1988). Stability of genetic determination from age 2 to age 9: A longitudinal twin study. Social Biology, 35, 62–73.PubMedGoogle Scholar
  84. Manuck, S. B., Flory, J. D., Ferrell, R. E., Dent, K. M., Mann, J. J.,&Muldoon, M. F. (1999). Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biological Psychiatry, 45, 603–614.PubMedGoogle Scholar
  85. Manuck, S. B., Flory, J. D., Ferrell, R. E., Mann, J. J.,&Muldoon, M. F. (2000). A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Research, 95, 9–23.PubMedGoogle Scholar
  86. McCartney, K., Harris, M. J.,&Bernieri, F. (1990). Growing up and growing apart: A developmental meta-analysis of twin studies. Psychological Bulletin, 107, 226–237.PubMedGoogle Scholar
  87. McClelland, G. H,&Judd, C. M. (1993). Statistical difficulties of detecting interactions and moderator effects. Psychological Bulletin, 114, 376–390.PubMedGoogle Scholar
  88. * McGue, M., Sharma, A.,&Benson, P. (1996). The effect of common rearing on adolescent adjustment: Evidence from a U.S. adoption cohort. Developmental Psychology, 32, 604–613.Google Scholar
  89. Mednick, S. A., Gabrielli, W. F,&Hutchings, B. (1983). Genetic influences in criminal behavior: Evidence from an adoption cohort. In K. T. Van Dusen&S. A. Mednick (Eds.), Prospective studies of crime and delinquency (pp. 39–56). Boston, MA: Kluwer-Nijhof.Google Scholar
  90. * Meininger, J. C., Hayman, L. L., Coates, P. M,&Gallagher, P. (1988). Genetics or environment? Type A behavior and cardiovascular risk factors in twin children. Nursing Research, 37, 341–346.PubMedGoogle Scholar
  91. Miles, D. R., van den Bree, M. B.,&Pickens, R. W. (2002). Sex differences in shared genetic and environmental influences between conduct disorder symptoms and marijuana use in adolescents. American Journal of Medical Genetics, 114, 159–168.PubMedGoogle Scholar
  92. Mill, J., Xu, X., Ronald, A., Curran, S., Price, T., Knight, J., et al. (2005). Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B. American Journal of Medical Genetics, 133, 68–73.Google Scholar
  93. Moffitt, T. E. (1993). Adolescence-limited and life-course-persistent antisocial behavior: A developmental taxonomy. Psychological Review, 100, 674–701.PubMedGoogle Scholar
  94. Moffitt, T. E., Caspi, A.,&Rutter, M. (2005). Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry, 62, 473–481.PubMedGoogle Scholar
  95. Nadder, T. S., Rutter, M., Silberg, J. L., Maes, H. H.,&Eaves, L. J. (2002). Genetic effects on the variation and covariation of attention deficit-hyperactivity disorder (ADHD) and oppositional-defiant disorder/conduct disorder (Odd/CD) symptomatologies across informant and occasion of measurement. Psychological Medicine, 32, 39–53.PubMedGoogle Scholar
  96. Nadder, T. S., Silberg, J. L., Eaves, L. J., Maes, H. H.,&Meyer, J. M. (1998). Genetic effects on ADHD symptomatology in 7- to 13-year-old twins: Results from a telephone survey. Behavior Genetics, 28, 83–99.PubMedGoogle Scholar
  97. * Nathawat, S. S,&Puri, P. (1995). A comparative study of MZ and DZ twins on level I and level II mental abilities and personality. Journal of the Indian Academy of Applied Psychology, 21, 87–92.Google Scholar
  98. New, A. S., Gelernter, J., Goodman, M., Mitropoulou, V., Koenigsberg, H., Silverman, J., et al. (2001). Suicide, impulsive aggression, and HTR1B genotype. Biological Psychiatry, 50, 62–65.PubMedGoogle Scholar
  99. New, A. S., Gelertner, J., Yovell, Y., Trestman, R. L., Nielsen, D. A., Silvermann, J., et al. (1998). Tryptophan hydroxylase genotype is associated with impulsive-aggression measures. A preliminary report. American Journal of Medical Genetics, 81, 13–17.PubMedGoogle Scholar
  100. Nilsson, K. W., Sjöberg, R. L., Damberg, M., Leppert, J., Öhrvik, J., Alm, P. O., et al. (2005). Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity. Biological Psychiatry, 59, 121–127.PubMedGoogle Scholar
  101. * O’Connor, T. G., McGuire, S., Reiss, D., Hetherington, E. M.,&Plomin, R. (1998). Co-occurrence of depressive symptoms and antisocial behavior in adolescence: A common genetic liability. Journal of Abnormal Psychology, 107, 27–37.PubMedGoogle Scholar
  102. * Owen, D.,&Sines, J. O. (1970). Heritability of personality in children. Behavior Genetics, 1, 235–248.PubMedGoogle Scholar
  103. Plomin, R. (1981). Heredity and temperament: A comparison of twin data for self-report questionnaires, parental ratings, and objectively assessed behavior. In L. Gedda, P. Parisi,&W. E. Nance (Eds.), Twin research 3: Intelligence, personality, and development (pp. 269–278). New York: Alan R. Liss, Inc.Google Scholar
  104. Plomin, R., DeFries, J. C., McClearn, G. E.,&McGuffin, P. (2001). Behavioral genetics (4th ed.). New York: Worth Publishers.Google Scholar
  105. * Plomin, R., Foch, T. T.,&Rowe, D. C. (1981). Bobo clown aggression in childhood: Environment, not genes. Journal of Research in Personality, 15, 331–342.Google Scholar
  106. Plomin, R., Nitz, K.,&Rowe, D. C. (1990). Behavioral genetics and aggressive behavior in childhood. In M. Lewis&S. M. Miller (Eds.), Handbook of developmental psychopathology (pp. 119–133). New York: Plenum Press.Google Scholar
  107. * Rahe, R. H., Hervig, L.,&Rosenman, R. H. (1978). Heritability of type A behavior. Psychosomatic Medicine, 40, 478–486.PubMedGoogle Scholar
  108. Reebye, P., Moretti, M. M.,&Lessard, J. C. (1995). Conduct disorder and substance use disorders: Comorbidity in a clinical sample of preadolescents and adolescents. Canadian Journal of Psychiatry, 40, 313–319.Google Scholar
  109. Reist, C., Mazzanti, C., Vu, R., Tran, D.,&Goldman, D. (2001). Serotonin transporter promoter polymorphism is associated with attenuated prolactin response to fenfluramine. American Journal of Medical Genetics, 105, 363–368.PubMedGoogle Scholar
  110. Retz, W., Retz-Junginger, P., Supprian, T., Thome, J.,&Rösler, M. (2004). Association of serotonin transporter promoter gene polymorphism with violence: Relation with personality disorders, impulsivity, and childhood ADHD psychopathology. Behavioral Sciences and the Law, 22, 415–425.PubMedGoogle Scholar
  111. Rhee, S. H,&Waldman, I. D. (2002). Genetic and environmental influences on antisocial behavior: A meta-analysis of twin and adoption studies. Psychological Bulletin, 128, 490–529.PubMedGoogle Scholar
  112. Robins, L. N,&Regier, D. A. (1991). Psychiatric disorders in America. New York: The Free Press.Google Scholar
  113. * Rowe, D. C. (1983). Biometrical genetic models of self-reported delinquent behavior: A twin study. Behavior Genetics, 13, 473–489.PubMedGoogle Scholar
  114. Rowe, D. C., Almeida, D. M.,&Jacobson, K. C. (1999). School context and genetic influences on aggression in adolescence. Psychological Science, 10, 277–280.Google Scholar
  115. * Rushton, J. P., Fulker, D. W., Neale, M. C., Nias, D. K. B,&Eysenck, H. J. (1986). Altruism and aggression: The heritability of individual differences. Journal of Personality and Social Psychology, 50, 1192–1198.PubMedGoogle Scholar
  116. Sabol, S. Z., Hu, S.,&Hamer, D. (1998). A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics, 103, 273–279.PubMedGoogle Scholar
  117. Sakai, J. T., Young, S. E., Stallings, M. C., Timberlake, D., Smolen, A., Stetler, G. L., et al. (2006). Case-control and within-family tests for an association between conduct disorder and 5HTTLPR. American Journal of Medical Genetics, 141, 825–832.Google Scholar
  118. Sander, T., Harms, H., Podschus, J., Finckh, U., Nickel, B., Rolfs, A., et al. (1997). Alellic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium. Biological Psychiatry, 41, 299–304.PubMedGoogle Scholar
  119. Saudou, F., Amara, D. A., Dierich, A., LeMeur, M., Ramboz, S., Segu, L., et al. (1994). Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science, 265, 1875–1878.PubMedGoogle Scholar
  120. * Scarr, S. (1966). Genetic factors in activity motivation. Child Development, 37, 663–673.PubMedGoogle Scholar
  121. Schmidt, L. G., Harms, H., Kuhn, S., Rommelspacher, H.,&Sander, T. (1998). Modification of alcohol withdrawal by the A 9 allele of the dopamine transporter gene. American Journal of Psychiatry, 155, 474–478.PubMedGoogle Scholar
  122. * Schmitz, S., Fulker, D. W.,&Mrazek, D. A. (1995). Problem behavior in early and middle childhood: An initial behavior genetic analysis. Journal of Child Psychology and Psychiatry, 36, 1443–1458.PubMedGoogle Scholar
  123. * Seelig, K. J.,&Brandon, K. O. (1997). Rater differences in gene-environment contributions to adolescent problem behavior. Behavior Genetics, 27, 605.Google Scholar
  124. Silberg, J., Rutter, M., D’Onofrio, B.,&Eaves, L. (2003). Genetic and environmental risk factors in adolescent substance use. Journal of Child Psychology and Psychiatry, 44, 664–676.PubMedGoogle Scholar
  125. Silberg, J., Rutter, M., Meyer, J., Maes, H., Hewitt, J., Simonoff, E., et al. (1996). Genetic and environmental influences on the covariation between hyperactivity and conduct disturbance in juvenile twins. Journal of Child Psychology and Psychiatry, 37, 803–816.PubMedGoogle Scholar
  126. * Slutske, W. S., Heath, A. C., Dinwiddie, S. H., Madden, P. A. F., Bucholz, K. K., Dunne, M. P., et al. (1997). Modeling genetic and environmental influences in the etiology of conduct disorder: A study of 2,682 adult twin pairs. Journal of Abnormal Psychology, 106, 266–279.PubMedGoogle Scholar
  127. Slutske, W. S., Heath, A. C., Dinwiddie, S. H., Madden, P. A., Bucholz, K. K., Dunne, M. P., et al. (1998). Common genetic risk factors for conduct disorder and alcohol dependence. Journal of Abnormal Psychology, 107, 363–374.PubMedGoogle Scholar
  128. Soyka, M., Preuss, U. W., Koller, G., Zill, P.,&Bondy, B. (2004). Association of 5-HT1B receptor gene and antisocial behavior in alcoholism. Journal of Neural Transmission, 111, 101–109.PubMedGoogle Scholar
  129. Stallings, M. C., Corley, R. P., Dennehey, B., Hewitt, J. K., Krauter, K. S., Lessem, J. M., et al. (2005). A genome-wide search for quantitative trait loci influencing antisocial drug dependence in adolescence. Archives of General Psychiatry, 62, 1042–1051.PubMedGoogle Scholar
  130. Staner, L., Uyanik, G., Correa, H., Tremeau, F., Monreal, J., Crocq, M. -A., et al. (2002). A dimensional impulsive-aggressive phenotype is associated with the A218C polymorphism of the tryptophan hydroxylase gene: A pilot study in well-characterized impulsive inpatients. American Journal of Medical Genetics, 114, 553–557.PubMedGoogle Scholar
  131. * Stevenson, J,&Graham, P. (1988). Behavioral deviance in 13-year-old twins: An item analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 27, 791–797.PubMedGoogle Scholar
  132. Strous, R. D., Nolan, K. A., Lapidus, R., Diaz, L., Saito, T.,&Lachman, H. M. (2003). Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: A replication study. American Journal of Medical Genetics, 120, 29–34.Google Scholar
  133. Taylor, J., Iacono, W. G.,&McGue, M. (2000). Evidence for a genetic etiology of early-onset delinquency. Journal of Abnormal Psychology, 109, 634–643.PubMedGoogle Scholar
  134. Taylor, J., Loney, B. R., Bobadilla, L., Iacono, W. G.,&McGue, M. (2003). Genetic and environmental influences on psychopathy trait dimensions in a community sample of male twins. Journal of Abnormal Child Psychology, 31, 633–645.PubMedGoogle Scholar
  135. * Taylor, J., McGue, M., Iacono, W. G.,&Lykken, D. T. (2000). A behavioral genetic analysis of the relationship between the socialization scale and self-reported delinquency. Journal of Personality, 68, 29–50.PubMedGoogle Scholar
  136. * Tellegen, A., Lykken, D. T., Bouchard, T. J., Wilcox, K., Segal, N.,&Rich, S. (1988). Personality similarity in twins reared apart and together. Journal of Personality and Social Psychology, 54, 1031–1039.PubMedGoogle Scholar
  137. Thapar, A., Harrington, R.,&McGuffin, P. (2001). Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design. British Journal of Psychiatry, 179, 224–229.PubMedGoogle Scholar
  138. Thapar, A., Langley, K., Fowler, T., Rice, F., Turic, D., Whittinger, N., et al. (2005). Catechol o-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 62, 1275–1278.PubMedGoogle Scholar
  139. * Thapar, A.,&McGuffin, P. (1996). A twin study of antisocial and neurotic symptoms in childhood. Psychological Medicine, 26, 1111–1118.PubMedGoogle Scholar
  140. * Torgersen, S. Skre, I., Onstad, S., Edvardsen, J.,&Kringlen, E. (1993). The psychometric-genetic structure of DSM-III-R personality disorder criteria. Journal of Personality Disorders, 7, 196–213.Google Scholar
  141. * van den Oord, E. J. C. G., Boomsma, D. I.,&Verhulst, F. C. (1994). A study of problem behaviors in 10- to 15-year-old biologically related and unrelated international adoptees. Behavior Genetics, 24, 193–205.PubMedGoogle Scholar
  142. * van den Oord, E. J. C. G., Verhulst, F. C.,&Boomsma, D. I. (1996). A genetic study of maternal and paternal ratings of problem behaviors in 3-year-old twins. Journal of Abnormal Psychology, 105, 349–357.PubMedGoogle Scholar
  143. Viding, E., Blair, R. J. R., Moffitt, T. E.,&Plomin, R. (2005). Evidence for substantial genetic risk for psychopathy in 7-year-olds. Journal of Child Psychology and Psychiatry, 46, 592–597.PubMedGoogle Scholar
  144. * Waldman, I. D., Levy, F.,&Hay, D. A. (1995). Multivariate genetic analyses of the overlap among DSM-III-R disruptive behavior disorder symptoms. Behavior Genetics, 25, 293–294.Google Scholar
  145. * Waldman, I. D., Pickens, R. W.,&Svikis, D. S. (1989). Sex differences in genetic and environmental components of childhood conduct problems. Behavior Genetics, 19, 779–780.Google Scholar
  146. Waldman, I. D,&Rhee, S. H. (2006). Genetic and environmental influences on psychopathy and antisocial behavior. In C. Patrick (Ed.), Handbook of psychopathy (pp. 205–228). New York: The Guilford Press.Google Scholar
  147. Waldman, I. D., Rhee, S. H.,&Levy, F. (2001). Causes of overlap among symptoms of ADHD, oppositional defiant disorder, and conduct disorder. In F. Levy&D. A. Hay (Eds.), Attention, genes, and ADHD (pp. 115–138). New York: Brunner-Routledge.Google Scholar
  148. Waldman, I. D., Rowe, D. C., Abramowitz, A., Kozel, S. T., Mohr, J. H., Sherman, S. L., et al. (1998). Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. American Journal of Human Genetics, 63, 1767–1776.PubMedGoogle Scholar
  149. Widom, C. S,&Brzustowicz, L. M. (2006). MAOA and the “cycle of violence”: childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biological Psychiatry, 60, 684–689.PubMedGoogle Scholar
  150. * Willcutt, E. G., Shyu, V., Green, P.,&Pennington, B. F. (1995, April). A twin study of the comorbidity of the disruptive behavior disorders of childhood. Paper presented at the annual meeting of the Society for Research in Child Development. Indianapolis, IN.Google Scholar
  151. Wilson, J. Q.,&Herrnstein, R. J. (1985). Crime and human nature. New York: Simon and Schuster.Google Scholar
  152. * Wilson, G. D., Rust, J.,&Kasriel, J. (1977). Genetic and family origins of humor preferences: A twin study. Psychological Reports, 41, 659–660.Google Scholar
  153. Winsberg, B. G,&Comings, D. E. (1999). Association of the dopamine transporter gene (DAT1) with poor methylphenidate response. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 1474–1477.PubMedGoogle Scholar
  154. Young, S. E., Smolen, A., Corley, R. P., Krauter, K. S., DeFries, J. C., Crowley, T. J., et al. (2002). Dopamine transporter polymorphism associated with externalizing behavior problems in children. American Journal of Medical Genetics, 114, 144–149.PubMedGoogle Scholar
  155. Young, S. E., Smolen, A., Hewitt, J. K., Haberstick, B. C., Stallings, M. C., Corley, R. P., et al. (2006). Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: Failure to confirm in adolescent patients. American Journal of Psychiatry, 163, 1019–1025.PubMedGoogle Scholar
  156. * Young, S. E., Stallings, M. C., Corley, R. P., Hewitt, J. K.,&Fulker, D. W. (1997). Sibling resemblance for conduct disorder and attention deficit-hyperactivity disorder in selected, adoptive, and control families. Behavior Genetics, 27, 612.Google Scholar
  157. Zalsman, G., Frisch, A., Bromberg, M., Gelernter, J., Michaelovsky, E., Campino, A., et al. (2001). Family-based association study of serotonin transporter promoter in suicidal adolescents: no association with suicidality but possible role in violence traits. American Journal of Medical Genetics, 105, 239–245.PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Institute for Behavioral GeneticsUniversity of ColoradoBoulderUSA
  2. 2.Department of PsychologyEmory UniversityAtlantaUSA

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