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Depression and Anxiety in Childhood and Adolescence: Developmental Pathways, Genes and Environment

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Depression and anxiety are amongst the most common mental health problems experienced in the general population (Kessler et al., 1994). It is now well established that these traits and disorders often have their origins in childhood. Nevertheless, relatively little is known about which etiological factors are important, how risk factors work together and what are the mechanisms that lead to depression and anxiety. In the last 15 years, there has been a large increase in epidemiological and behavior genetic research on childhood depression and anxiety. In this chapter we review the evidence from this research and highlight new directions for future research.

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References

  • Achenbach, T. (1991). Manual for the child behavior checklist/ 4–18 and 1991 profile. Burlington, VT: University of Vermont Department of Psychiatry.

    Google Scholar 

  • Angold, A., & Costello, E. J. (2000). The child and adolescent psychiatric assessment (CAPA). Journal of the American Academy of Child and Adolescent Psychiatry, 39, 39–48.

    Article  PubMed  CAS  Google Scholar 

  • Angold, A., Costello, E. J., & Erkanli, A. (1999). Comorbidity. Journal of Child Psychology and Psychiatry, 40, 57–87.

    Article  PubMed  CAS  Google Scholar 

  • Angold, A., Costello, E. J., Farmer, E. M., Burns, B. J., & Erkanli, A. (1999). Impaired but undiagnosed. Journal of the American Academy of Child Adolescent Psychiatry, 38, 129–137.

    Article  CAS  Google Scholar 

  • Angold, A., Costello, E. J., Messer, S. C., Pickles, A., Winder, F., & Silver, D. (1995). Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents. International Journal of Methods in Psychiatric Research, 5, 237–249.

    Google Scholar 

  • Angold, A., Erkanli, A., Silberg, J., Eaves, L., & Costello, E. J. (2002). Depression scale scores in 8–17 year olds: Effects of age and gender. Journal of Child Psychology and Psychiatry, 43, 1052–1063.

    Article  PubMed  Google Scholar 

  • Arseneault, L., Moffitt, T. E., Caspi, A., Taylor, A., Rijsdijk, F. V., Jaffee, S. R., et al. (2003). Strong genetic effects on cross-situational antisocial behaviour among 5-year-old children according to mothers, teachers, examiner-observers, and twins’ self-reports. Journal of Child Psychology and Psychiatry, 44, 832–848.

    Article  PubMed  Google Scholar 

  • Avenevoli, S., Stolar, M., Li, J., Dierker, L., & Merikangas, K. R. (2001). Comorbidity of depression in children and adolescents: Models and evidence form a prospective high-risk study. Biological Psychiatry, 49, 1071–1081.

    Article  PubMed  CAS  Google Scholar 

  • Barker, D. J. P. (1998.) Mothers, babies and health in later life. Edinburgh: Chruchill Livingston.

    Google Scholar 

  • Bartels, M., van den Oord, E. J., Hudziak, J. J., Rietveld, M. J., van Beijsterveldt, C. E., & Boomsma, D. I. (2004). Genetic and environmental mechanisms underlying stability and change in problem behaviors at ages 3, 7, 10, and 12. Developmental Psychology, 40, 852–867.

    Article  PubMed  CAS  Google Scholar 

  • Beidel, D. C., & Turner, S. M. (1997). At risk for anxiety: I. Psychopathology in the offspring of anxious parents. Journal of the American Academy of Child Adolescent Psychiatry, 36, 918–924.

    Article  CAS  Google Scholar 

  • Bell-Dolan, D. J., Last, C. G., & Strauss, C. C. (1990). Symptoms of anxiety disorders in normal children. Journal of the American Academy of Child Adolescent Psychiatry, 29, 759–765.

    Article  CAS  Google Scholar 

  • Biederman, J., Rosenbaum, J. F., Bolduc, E. A., Faraone, S. V., & Hirshfeld, D. R. (1991). A high risk study of young children of parents with panic disorder and agoraphobia with and without comorbid major depression. Psychiatry Research, 37, 333–348.

    Article  PubMed  CAS  Google Scholar 

  • Birmaher, B., Ryan, N. D., Williamson, D. E., Brent, D. A., Kaufman, J., Dahl, R. E., et al. (1996). Childhood and adolescent depression: A review of the past 10 years. Part I. Journal of the American Academy of Child Adolescent Psychiatry, 35, 1427–1439.

    Article  CAS  Google Scholar 

  • Boomsma, D. I., van Beijsterveldt, C. E., & Hudziak, J. J. (2005). Genetic and environmental influences on anxious/depression during childhood: A study from the Netherlands Twin Register. Genes Brain and Behavior, 4, 466–481.

    Article  CAS  Google Scholar 

  • Brady, E. U., & Kendall, P. C. (1992). Comorbidity of anxiety and depression in children and adolescents. Psychological Bulletin, 111, 244–255.

    Article  PubMed  CAS  Google Scholar 

  • Brown, G. W., & Harris, T. O. (1978). Social origins of depression: A study of psychiatric disorder in women. London: Tavistock.

    Google Scholar 

  • Cantwell, D. P., Lewinsohn, P. M., Rohde, P., & Seeley, J. R. (1997). Correspondence between adolescent report and parent report of psychiatric diagnostic data. Journal of the American Academy of Child Adolescent Psychiatry, 36, 610–619.

    CAS  Google Scholar 

  • Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386–389.

    Article  PubMed  CAS  Google Scholar 

  • Cole, D. A., Tram, J. M., Martin, J. M., Hoffman, K. B., Ruiz, M. D., Jacquez, F. M., et al. (2002). Individual differences in the emergence of depressive symptoms in children and adolescents: A longitudinal investigation of parent and child reports. Journal of Abnormal Psychology, 111, 156–165.

    Article  PubMed  Google Scholar 

  • Connell, A. M., & Goodman, S. H. (2002). The association between psychopathology in fathers versus mothers and children’s internalizing and externalizing behavior problems: A meta-analysis. Psychological Bulletin, 128, 746–773.

    Article  PubMed  Google Scholar 

  • Costello, E. J., Angold, A., Burns, B. J., Erkanli, A., Stangl, D. K., & Tweed, D. L. (1996). The Great Smoky Mountains Study of youth. Functional impairment and serious emotional disturbance. Archives of General Psychiatry, 53(12), 1137–1143.

    PubMed  CAS  Google Scholar 

  • Costello, E. J., Mustillo, S., Erkanli, A., Keeler, G., & Angold, A. (2003). Prevalence and development of psychiatric disorders in childhood and adolescence. Archives of General Psychiatry, 60, 837–844.

    Article  PubMed  Google Scholar 

  • Cronk, N. J., Slutske, W. S., Madden, P. A., Bucholz, K. K., & Heath, A. C. (2004). Risk for separation anxiety disorder among girls: Paternal absence, socioeconomic disadvantage, and genetic vulnerability. Journal of Abnormal Psychology, 113, 237–247.

    Article  PubMed  Google Scholar 

  • Deater-Deckard, K., Reiss, D., Hetherington, E. M., & Plomin, R. (1997). Dimensions and disorders of adolescent adjustment: A quantitative genetic analysis of unselected samples and selected extremes. Journal of Child Psychology and Psychiatry, 38, 515–525.

    Article  PubMed  CAS  Google Scholar 

  • DeFries, J. C., & Fulker, D. W. (1985). Multiple regression analysis of twin data. Behavior Genetics, 15, 467–473.

    Article  PubMed  CAS  Google Scholar 

  • Downey, G., & Coyne, J. C. (1990). Children of depressed parents: An integrative review. Psychological Bulletin, 108, 50–76.

    Article  PubMed  CAS  Google Scholar 

  • Eaves, L., Silberg, J., & Erkanli, A. (2003). Resolving multiple epigenetic pathways to adolescent depression. Journal of Child Psychology and Psychiatry, 44, 1006–1014.

    Article  PubMed  Google Scholar 

  • Eaves, L. J., Silberg, J. L., Meyer, J. M., Maes, H. H., Simonoff, E., Pickles, A., et al. (1997). Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the Virginia Twin Study of Adolescent Behavioral Development. Journal of Child Psychology and Psychiatry, 38, 965–980.

    Article  PubMed  CAS  Google Scholar 

  • Edelbrock, C., Rende, R., Plomin, R., & Thompson, L. (1995). A twin study of competence and problem behavior in childhood and early adolescence. Journal of Child Psychology and Psychiatry, 36, 775–785.

    Article  PubMed  CAS  Google Scholar 

  • Eley, T. C. (1997). Depressive symptoms in children and adolescents: Etiological links between normality and abnormality: A research note. Journal of Child Psychology and Psychiatry, 38, 861–865.

    Article  PubMed  CAS  Google Scholar 

  • Eley, T. C., Bolton, D., O’Connor, T. G., Perrin, S., Smith, P., & Plomin, R. (2003). A twin study of anxiety-related behaviours in pre-school children. Journal of Child Psychology and Psychiatry, 44, 945–960.

    Article  PubMed  Google Scholar 

  • Eley, T. C., Deater-Deckard, K., Fombonne, E., Fulker, D. W., & Plomin, R. (1998). An adoption study of depressive symptoms in middle childhood. Journal of Child Psychology and Psychiatry, 39, 337–345.

    Article  PubMed  CAS  Google Scholar 

  • Eley, T.C., Liang, H., Plomin, R., Sham, P., Sterne, A., Williamson, R., et al. (2004). Parental familial vulnerability, family environment, and their interactions as predictors of depressive symptoms in adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 43, 298–306.

    Article  PubMed  Google Scholar 

  • Eley, T. C., & Stevenson, J. (1999). Exploring the covariation between anxiety and depression symptoms: A genetic analysis of the effects of age and sex. Journal of Child Psychology and Psychiatry, 40, 1273–1282.

    Article  PubMed  CAS  Google Scholar 

  • Eley, T. C., Sugden, K., Corsico, A., Gregory, A. M., Sham, P., McGuffin, P., et al. (2004). Gene–environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry, 9, 908–915.

    Article  PubMed  CAS  Google Scholar 

  • Fombonne, E., Wostear, G., Cooper, V., Harrington, R., & Rutter, M. (2001). The Maudsley long-term follow-up of child and adolescent depression. 1. Psychiatric outcomes in adulthood. British Journal of Psychiatry, 179, 210–217.

    Article  PubMed  CAS  Google Scholar 

  • Gjone, H., Stevenson, J., Sundet, J. M., & Eilertsen, D. E. (1996). Changes in heritability across increasing levels of behavior problems in young twins. Behavior Genetics, 26, 419–426.

    Article  PubMed  CAS  Google Scholar 

  • Gjone, H., & Stevenson, J. (1997). The association between internalizing and externalizing behavior in childhood and early adolesecence: Genetic or environmental common influences? Journal of Abnormal Child Psychology 25, 277–286.

    Article  PubMed  CAS  Google Scholar 

  • Glowinski, A. L., Madden, P. A., Bucholz, K. K., Lynskey, M. T., & Heath, A. C. (2003). Genetic epidemiology of self-reported lifetime DSM-IV major depressive disorder in a population-based twin sample of female adolescents. Journal of Child Psychology and Psychiatry, 44, 988–996.

    Article  PubMed  Google Scholar 

  • Goodman, S. H., & Gotlib, I. H. (1999). Risk for psychopathology in the children of depressed mothers: A developmental model for understanding mechanisms of transmission. Psychological Review, 106, 458–490.

    Article  PubMed  CAS  Google Scholar 

  • Goodwin, R. D., Fergusson, D. M., & Horwood, L. J. (2004). Early anxious/withdrawn behaviors predict later internalizing disorders. Journal of Child Psychology and Psychiatry, 45, 874–883.

    Article  PubMed  Google Scholar 

  • Goodyer, I. M., Cooper, P. J., Vize, C. M., & Ashby, L. (1993). Depression in 11–16-year-old girls: The role of past parental psychopathology and exposure to recent life events. Journal of Child Psychology and Psychiatry, 34, 1103–1115.

    Article  PubMed  CAS  Google Scholar 

  • Goodyer, I., Kolvin, I., & Gatzanis, S. (1985). Recent undesirable life events and psychiatric-disorder in childhood and adolescence. British Journal of Psychiatry 147, 517–523.

    Article  PubMed  CAS  Google Scholar 

  • Gollan, J., Raffety, B., Gortner, E., & Dobson, K. (2005). Course profiles of early- and adult-onset depression. Journal of Affective Disorders, 86, 81–86.

    Article  PubMed  Google Scholar 

  • Hammen, C., Burge, D., Burney, E., & Adrian, C. (1990). Longitudinal study of diagnoses in children of women with unipolar and bipolar affective disorder. Archives of General Psychiatry, 47, 1112–1117.

    PubMed  CAS  Google Scholar 

  • Happonen, M., Pulkkinen, L., Kaprio, J., van der Meere, J., Viken, R. J., & Rose, R. J. (2002). The heritability of depressive symptoms: Multiple informants and multiple measures. Journal of Child Psychology and Psychiatry, 43, 471–480.

    Article  PubMed  Google Scholar 

  • Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, L. S., Mattay, V. S., Egan, M. F., et al. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry, 62, 146–152.

    Article  PubMed  CAS  Google Scholar 

  • Harrington, R. (1994). Affective disorders. In M. Rutter, E. Taylor, & L. Hersov, (Eds.), Child and adolescent psychiatry: Modern approaches (pp. 330–345). Oxford: Blackwell Scientific Publications.

    Google Scholar 

  • Harrington, R., Fudge, H., Rutter, M., Pickles, A., & Hill, J. (1990). Adult outcomes of childhood and adolescent depression. I. Psychiatric status. Archives of General Psychiatry, 47, 465–473.

    PubMed  CAS  Google Scholar 

  • Harrington, R., Fudge, H., Rutter, M., Pickles, A., & Hill, J. (1991). Adult outcomes of childhood and adolescent depression. 2. Links with antisocial disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 434–439.

    Article  PubMed  CAS  Google Scholar 

  • Harrington, R., Rutter, M., Weissman, M., Fudge, H., Groothues, C., Bredenkamp, D., et al. (1997). Psychiatric disorders in the relatives of depressed probands. I. Comparison of prepubertal, adolescent and early adult onset cases. Journal of Affective Disorders, 42, 9–22.

    Article  PubMed  CAS  Google Scholar 

  • Hay, D. F., Pawlby, S., Sharp, D., Schmucker, G., Mills, A., Allen, H., et al. (1999). Parents’ judgements about young children’s problems: Why mothers and fathers might disagree yet still predict later outcomes. Journal of Child Psychology and Psychiatry, 40, 1249–1258.

    Article  PubMed  CAS  Google Scholar 

  • Jaffee, S. R., & Price, T. S. (2007). Gene environment correlations: A review of the evidence and implications for prevention of mental illness. Molecular Psychiatry, 12, 432–442.

    PubMed  CAS  Google Scholar 

  • Johnson, J., Weissman, M. M., & Klerman, G. L. (1992). Service utilization and social morbidity associated with depressive symptoms in the community. JAMA, 267, 1478–1483.

    Article  PubMed  CAS  Google Scholar 

  • Kane, P., & Garber, J. (2004). The relations among depression in fathers, children’s psychopathology, and father–child conflict: A meta-analysis. Clinical Psychology Review, 24, 339–360.

    Article  PubMed  Google Scholar 

  • Keller, M. B., Beardslee, W. R., Dorer, D. J., Lavori, P. W., Samuelson, H., & Klerman, G. R. (1986). Impact of severity and chronicity of parental affective illness on adaptive functioning and psychopathology in children. Archives of General Psychiatry, 43, 930–937.

    PubMed  CAS  Google Scholar 

  • Kendler, K. S., Kuhn, J. W., Vittum, J., Prescott, C. A., & Riley, B. (2005). The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: A replication. Archives of General Psychiatry, 62, 529–535.

    Article  PubMed  CAS  Google Scholar 

  • Kessler, R. C., McGonagle, K. A., Zhao, S., Nelson, C. B., Hughes, M., Eshleman, S., et al. (1994). Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Archives of General Psychiatry, 51, 8–19.

    PubMed  CAS  Google Scholar 

  • Kim-Cohen, J., Moffitt, T. E., Taylor, A., Pawlby, S. J., & Caspi, A. (2005). Maternal depression and children’s antisocial behavior – Nature and nurture effects. Archives of General Psychiatry, 62, 173–181.

    Article  PubMed  Google Scholar 

  • Klein, D. N., Shankman, S. A., Lewinsohn, P. M., Rohde, P., & Seeley, J. R. (2004). Family study of chronic depression in a community sample of young adults. American Journal of Psychiatry, 161, 646–653.

    Article  PubMed  Google Scholar 

  • Kovacs, M., & Devlin, B. (1998). Internalizing disorders in childhood. Journal of Child Psychology and Psychiatry, 39, 47–63.

    Article  PubMed  CAS  Google Scholar 

  • Kovacs, M., Gatsonis, C., Paulauskas, S. L., & Richards, C. (1989). Depressive disorders in childhood. IV. A longitudinal study of comorbidity with and risk for anxiety disorders. Archives of General Psychiatry, 46, 776–782.

    PubMed  CAS  Google Scholar 

  • Kutcher, S., & Marton, P. (1991). Affective disorders in first-degree relatives of adolescent onset bipolars, unipolars, and normal controls. Journal of the American Academy of Child Adolescent Psychiatry, 30, 75–78.

    Article  CAS  Google Scholar 

  • Last, C. G., Hansen, C., & Franco, N. (1997). Anxious children in adulthood: A prospective study of adjustment. Journal of the American Academy of Child Adolescent Psychiatry, 36, 645–652.

    Article  CAS  Google Scholar 

  • Last, C. G., Hersen, M., Kazdin, A., Orvaschel, H., & Perrin, S. (1991). Anxiety disorders in children and their families. Archives of General Psychiatry, 48, 928–934.

    PubMed  CAS  Google Scholar 

  • Last, C. G., Perrin, S., Hersen, M., & Kazdin, A. E. (1996). A prospective study of childhood anxiety disorders. Journal of the American Academy of Child Adolescent Psychiatry, 35, 1502–1510.

    Article  CAS  Google Scholar 

  • Lau, J. Y. F., & Eley, T. C. (2006). Changes in genetic and environmental influences on depressive symptoms across adolescence and young adulthood. British Journal of Psychiatry, 189, 422–427.

    Article  PubMed  Google Scholar 

  • Legrand, L. N., McGue, M., & Iacono, W. G. (1999). A twin study of state and trait anxiety in childhood and adolescence. Journal of Child Psychology and Psychiatry, 40, 953–958.

    Article  PubMed  CAS  Google Scholar 

  • Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527–1531.

    Article  PubMed  CAS  Google Scholar 

  • Lewinsohn, P. M., Hoberman, H. M., & Rosenbaum, M. (1988). A prospective study of risk factors for unipolar depression. Journal of Abnormal Psychology, 97, 251–264.

    Article  PubMed  CAS  Google Scholar 

  • Lewinsohn, P. M., Hops, H., Roberts, R. E., Seeley, J. R., & Andrews, J. A. (1993). Adolescent psychopathology: I. Prevalence and incidence of depression and other DSM-III-R disorders in high school students. Journal of Abnormal Psychology, 102, 133–144.

    Article  PubMed  CAS  Google Scholar 

  • Lewinsohn, P. M., Solomon, A., Seeley, J. R., & Zeiss, A. (2002). Clinical implications of ‘subthreshold’ depressive symptoms. Journal of Abnormal Psychology, 109, 345–351.

    Article  Google Scholar 

  • Lewinsohn, P. M., Zinbarg, R., Seeley, J. R., Lewinsohn, M., & Sack, W. H (1997). Lifetime comorbidity among anxiety disorders and between anxiety disorders and other mental disorders in adolescents. Journal of Anxiety Disorders, 11, 377–394.

    Article  PubMed  CAS  Google Scholar 

  • Loehlin, J. C. (1996). The Cholesky approach: A cautionary note. Behavior Genetics, 26, 65–69.

    Article  Google Scholar 

  • Marks, M., Hipwell, A. E., & Kumar, R. C. (2002). Implications for the infant of maternal puerperal psychiatric disorders. In M. Rutter, & E. Taylor (Eds.), Child and adolescent psychiatry (pp. 858–880). Oxford: Blackwell Scientific Publications.

    Google Scholar 

  • Meltzer, H., Gatward, R., & Ford, T. (2000). Mental health of children and adolescents in Great Britain. London: The Stationery Office.

    Google Scholar 

  • Merikangas, K. R. (1993). Genetic epidemiologic studies of affective disorders in childhood and adolescence. European Archives of Psychiatry and Clinical Neuroscience, 243, 121–130.

    Article  PubMed  CAS  Google Scholar 

  • Merikangas, K. R., Zhang, H. P., Avenevoli, S., Acharyya, S., Neuenschwander, M., & Angst, J. (2003). Longitudinal trajectories of depression and anxiety in a prospective community study – The Zurich cohort study. Archives of General Psychiatry, 60, 993–1000.

    Article  PubMed  Google Scholar 

  • Mitchell, J., McCauley, E., Burke, P., Calderon, R., & Schloredt, K. (1989). Psychopathology in parents of depressed children and adolescents. Journal of the American Academy of Child Adolescent Psychiatry, 28, 352–357.

    Article  CAS  Google Scholar 

  • Moffitt, T. E., Caspi, A., & Rutter, M. (2005). Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry, 62, 473–481.

    Article  PubMed  CAS  Google Scholar 

  • Mufson, L., Weissman, M. M., & Warner, V. (1992). Depression and anxiety in parents and children: A direct interview study. Journal of Anxiety Disorders, 6, 1–13.

    Article  Google Scholar 

  • Murray, K. T., & Sines, J. O. (1996). Parsing the genetic and nongenetic variance of children’s depressive behavior. Journal of Affective Disorders, 38, 23–34.

    Article  PubMed  CAS  Google Scholar 

  • Neale, M. C., & Cardon. L. R. (1992). Methodology for genetic studies of twins and families. Series D: Behavioural and social sciences. Dordrecht: Kluwer Academic Publishers.

    Google Scholar 

  • Neiderhiser, J. M., Reiss, D., Hetherington, E. M., & Plomin, R. (1999). Relationships between parenting and adolescent adjustment over time: Genetic and environmental contributions. Developmental Psychology, 35, 680–692.

    Article  PubMed  CAS  Google Scholar 

  • Neuman, R. J., Geller, B., Rice, J. P., & Todd, R. D. (1997). Increased prevalence and earlier onset of mood disorders among relatives of prepubertal versus adult probands. Journal of the American Academy of Child Adolescent Psychiatry, 36, 466–473.

    Article  CAS  Google Scholar 

  • O’Connor, T. G., Deater-Deckard, K., Fulker, D., Rutter, M., & Plomin, R. (1998). Genotype-environment correlations in late childhood and early adolescence: Antisocial behavioral problems and coercive parenting. Developmental Psychology, 34, 970–981.

    Article  PubMed  CAS  Google Scholar 

  • O’Connor, T. G., Heron, J., Golding, J., & Glover, V. (2003). Maternal antenatal anxiety and behavioural/emotional problems in children: A test of a programming hypothesis. Journal of Child Psychology and Psychiatry, 44, 1025–1036.

    Article  PubMed  Google Scholar 

  • O’Connor, T. G., McGuire, S., Reiss, D., Hetherington, M., & Plomin, R. (1998). Co-occurrence of depressive symptoms and antisocial behavior in adolescence: A common genetic liability. Journal of Abnormal Psychology, 107, 27–37.

    Article  PubMed  CAS  Google Scholar 

  • Orvaschel, H., Lewinsohn, P. M., & Seeley, J. R. (1995). Continuity of psychopathology in a community sample of adolescents. Journal of the American Academy of Child Adolescent Psychiatry, 34, 1525–1535.

    Article  CAS  Google Scholar 

  • Orvaschel, H., Walsh-Allis, G., & Ye, W. (1989). Psychopathology in children of parents with recurrent depression. Journal of Abnormal Child Psychology, 16, 17–28.

    Article  Google Scholar 

  • Parker, G., Roy, K., Hadzi-Pavlovic, B., Mitchell, D., & Wilhelm, K. (2003). Distinguishing early and late onset non-melancholic unipolar depression. Journal of Affective Disorders, 74, 131–138.

    Article  PubMed  Google Scholar 

  • Patton, G. C., Coffey, C., Carlin, J. B., Olsson, C. A., & Morley, R. (2004). Prematurity at birth and adolescent depressive disorder. British Journal of Psychiatry, 184, 446–447.

    Article  PubMed  Google Scholar 

  • Pickles, A., Rowe, R., Simonoff, E., Foley, D., Rutter, M., & Silberg, J. (2001). Child psychiatric symptoms and psychosocial impairment: Relationship and prognostic significance. British Journal of Psychiatry, 179, 230–235.

    Article  PubMed  CAS  Google Scholar 

  • Pike, A., McGuire, S., Hetherington, E. M., Reiss, D., & Plomin, R. (1996). Family environment and adolescent depressive symptoms and antisocial behavior: A multivariate genetic analysis. Developmental Psychology, 32, 590–603.

    Article  Google Scholar 

  • Pine, D. S., Cohen, P., & Brook, J. (2001). Adolescent fears as predictors of depression. Biological Psychiatry, 50, 721–724.

    Article  PubMed  CAS  Google Scholar 

  • Pine, D. S., Cohen, E., Cohen, P., & Brook, J. (1999). Adolescent depressive symptoms as predictors of adult depression: Moodiness or mood disorder? American Journal of Psychiatry, 156, 133–135.

    PubMed  CAS  Google Scholar 

  • Pleck, J. (1997). Paternal involvement: Levels, sources and consequences. In M. E. Lamb (Ed.), The role of the father in child development (3rd ed., pp. 66–103). New York: Wiley.

    Google Scholar 

  • Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2001). Behavioral genetics (4th ed.). New York: Worth.

    Google Scholar 

  • Puig-Antich, J., Goetz, D., Davies, M., Kaplan, T., Davies, S., Ostrow, L., et al. (1989). A controlled family history study of prepubertal major depressive disorder. Archives of General Psychiatry, 46, 406–418.

    PubMed  CAS  Google Scholar 

  • Radke-Yarrow, M., Nottelmann, E., Martinez, P., Fox, M. B., & Belmont, B. (1992). Young children of affectively ill parents: A longitudinal study of psychosocial development. Journal of the American Academy of Child Adolescent Psychiatry, 31, 68–77.

    Article  CAS  Google Scholar 

  • Ramchandani, P., Stein, A., Evans, J., & O’Connor, T. G. (2005). ALSPAC study team. Paternal depression in the postnatal period and child development: A prospective population study (2005). Lancet, 365, 2201–2205.

    Article  PubMed  Google Scholar 

  • Rende, R. D., Plomin, R., Reiss, D., & Hetherington, E. M. (1993). Genetic and environmental influences on depressive symptomatology in adolescence: Individual differences and extreme scores. Journal of Child Psychology and Psychiatry, 34, 1387–1398.

    Article  PubMed  CAS  Google Scholar 

  • Rende, R., Warner, V., Wickramarante, P., & Weissman, M. M. (1999). Sibling aggregation for psychiatric disorders in offspring at high and low risk for depression: 10-year follow-up. Psychological Medicine, 29, 1291–1298.

    Article  PubMed  CAS  Google Scholar 

  • Reynolds, C. R., & Richards B. O. (1978). What I think and feel: A revised measure of children’s manifest anxiety. Journal of Abnormal Child Psychology, 6, 271–280.

    Article  PubMed  CAS  Google Scholar 

  • Rice, F., Harold, G. T., Shelton, K. H., & Thapar, A. (2006). Family conflict interacts with genetic liability in predicting childhood and adolescent depression. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 841–848.

    Article  PubMed  Google Scholar 

  • Rice, F., Harold, G., & Thapar, A. (2002a). The genetic aetiology of childhood depression: A review. Journal of Child Psychology and Psychiatry, 43, 65–79.

    Article  PubMed  Google Scholar 

  • Rice, F., Harold, G. T., & Thapar, A. (2002b). Assessing the effects of age, sex and shared environment on the genetic aetiology of depression in childhood and adolescence. Journal of Child Psychology and Psychiatry, 43, 1039–1051.

    Article  PubMed  Google Scholar 

  • Rice, F., Harold, G. T., & Thapar, A. (2003). Negative life events as an account of age-related differences in the genetic aetiology of depression in childhood and adolescence. Journal of Child Psychology and Psychiatry, 44, 977–987.

    Article  PubMed  Google Scholar 

  • Rice, F., Harold, G. T., & Thapar, A. (2005). The link between depression in mothers and offspring: an extended twin analysis. Behavior Genetics, 35, 565–577.

    Article  PubMed  Google Scholar 

  • Rice, F., van den Bree, M. B., & Thapar, A. (2004). A population-based study of anxiety as a precursor for depression in childhood and adolescence. BMC Psychiatry, 4, 43.

    Article  PubMed  Google Scholar 

  • Rutter, M. (2006). Genes and behavior: Nature–nurture interplay explained. Oxford: Blackwell Publishing.

    Google Scholar 

  • Rutter, M., Pickles, A., Murray, R., & Eaves, L. (2001). Testing hypotheses on specific environmental causal effects on behavior. Psychological Bulletin, 127, 291–324.

    Article  PubMed  CAS  Google Scholar 

  • Rutter, M., & Quinton, D. (1984). Parental psychiatric disorder: Effects on children. Psychological Medicine, 14, 853–880.

    Article  PubMed  CAS  Google Scholar 

  • Rutter, M., & Silberg, J. (2002). Gene-environment interplay in relation to emotional and behavioral disturbance. Annual Review of Psychology, 53, 463–490.

    Article  PubMed  Google Scholar 

  • Scarr, S., & McCartney, K. (1983). How people make their own environments – A theory of genotype-environment effects. Child Development, 54, 424–435.

    PubMed  CAS  Google Scholar 

  • Schmitz, S., Fulker, D. W., & Mrazek, D. A. (1995). Problem behavior in early and middle childhood: An initial behavior genetic analysis. Journal of Child Psychology and Psychiatry, 36, 1443–1458.

    Article  PubMed  CAS  Google Scholar 

  • Scourfield, J., Rice, F., Thapar, A., Harold, G. T., Martin, N., & McGuffin, P. (2003). Depressive symptoms in children and adolescents: Changing aetiological influences with development. Journal of Child Psychology and Psychiatry, 44, 968–976.

    Article  PubMed  Google Scholar 

  • Scourfield, J., van den Bree, M., Martin, N., & McGuffin, P. (2004). Conduct problems in children and adolescents – A twin study. Archives of General Psychiatry, 61, 489–496.

    Article  PubMed  Google Scholar 

  • Seckl, J. R., & Meaney, M. J. (2004). Glucocorticoid programming. Annals of the New York Academy of Science, 1032, 63–84.

    Article  CAS  Google Scholar 

  • Silberg, J., & Eaves, L. J. (2004). Analysing the contributions of genes and parent–child interaction to childhood behavioural and emotional problems: A model for the children of twins. Psychological Medicine, 34, 347–356.

    Article  PubMed  CAS  Google Scholar 

  • Silberg, J., Erikson, M. T., Meyer, J. M., Eaves, L. J., Rutter, M. L., & Hewitt, J. K. (1994). The application of structural equation modeling to maternal ratings of twins’ behavioural and emotional problems. Journal of Consulting and Clinical Psychology, 62, 510–521.

    PubMed  CAS  Google Scholar 

  • Silberg, J., Pickles, A., Rutter, M., Hewitt, J., Simonoff, E., Maes, H., et al. (1999). The influence of genetic factors and life stress on depression among adolescent girls. Archives of General Psychiatry, 56, 225–232.

    Article  PubMed  CAS  Google Scholar 

  • Silberg, J., Rutter, M., Neale, M., & Eaves, L. (2001). Genetic moderation of environmental risk for depression and anxiety in adolescent girls. British Journal of Psychiatry, 179, 116–121.

    Article  PubMed  CAS  Google Scholar 

  • Silman, A. J. (1995). Epidemiological studies: A practical guide. Cambridge: Cambridge University Press.

    Google Scholar 

  • Simonoff, E., Pickles, A., Meyer, J. M., Silberg, J. L., Maes, H. H., Loeber, R., et al. (1997). The Virginia twin study of adolescent behavioral development. Influences of age, sex, and impairment on rates of disorder. Archives of General Psychiatry, 54, 801–808.

    PubMed  CAS  Google Scholar 

  • Spitzer, R. L., Endicott, J., & Robins, E. (1978). Research diagnostic criteria: Rationale and reliability. Archives of General Psychiatry, 35, 773–782.

    PubMed  CAS  Google Scholar 

  • Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000). Genetic epidemiology of major depression: Review and meta-analysis. American Journal of Psychiatry, 157, 1552–1562.

    Article  PubMed  CAS  Google Scholar 

  • Thapar, A., Harold, G., & McGuffin, P. (1998). Life events and depressive symptoms in childhood – Shared genes or shared adversity? A research note. Journal of Child Psychology and Psychiatry, 39, 1153–1158.

    Article  PubMed  CAS  Google Scholar 

  • Thapar, A., Harrington, R., Ross, K., & McGuffin, P. (2000). Does the definition of ADHD affect heritability? Journal of the American Academy of Child Adolescent Psychiatry, 39, 1528–1536.

    Article  CAS  Google Scholar 

  • Thapar, A., & McGuffin, P. (1994). A twin study of depressive symptoms in childhood. British Journal of Psychiatry, 165, 259–265.

    Article  PubMed  CAS  Google Scholar 

  • Thapar, A., & McGuffin, P. (1995). Are anxiety symptoms in childhood heritable? Journal of Child Psychology and Psychiatry, 36, 439–4475.

    Article  PubMed  CAS  Google Scholar 

  • Thapar, A., & McGuffin, P. (1997). Anxiety and depressive symptoms in childhood – A genetic study of comorbidity. Journal of Child Psychology and Psychiatry, 38, 651–656.

    Article  PubMed  CAS  Google Scholar 

  • Van den Oord, E., Boomsma, D. I., & Verhulst, F. C. (1994). A study of problem behaviors in 10 to 15 year old biologically related and unrelated international adoptees. Behavior Genetics, 24, 193–205.

    Article  PubMed  Google Scholar 

  • Van den Oord, E. J., Pickles, A., & Waldman, I. D. (2003). Normal variation and abnormality: An empirical study of the liability distributions underlying depression and delinquency. Journal of Child Psychology and Psychiatry, 44, 180–192.

    Article  PubMed  Google Scholar 

  • Verhulst, F. C., Dekker, M. C., & vanderEnde, J. (1997). Parent, teacher and self-reports as predictors of signs of disturbance in adolescents: Whose information carries the most weight? Acta Psychiatrica Scandinavica, 96, 75–81.

    Article  PubMed  CAS  Google Scholar 

  • Warner, V., Mufson, L., & Weissman, M. M. (1995). Offspring at high and low risk for depression and anxiety: Mechanisms of psychiatric disorder. Journal of the American Academy of Child Adolescent Psychiatry, 34, 786–797.

    Article  CAS  Google Scholar 

  • Warner, V., Weissman, M. M., Mufson, L., & Wickramaratne, P. J. (1999). Grandparents, parents, and grandchildren at high risk for depression: A three-generation study. Journal of the American Academy of Child Adolescent Psychiatry, 38, 289–296.

    Article  CAS  Google Scholar 

  • Weissman, M. M., Fendrich, M., Warner, V., & Wickramaratne, P. (1992). Incidence of psychiatric disorder in offspring at high and low risk for depression. Journal of the American Academy of Child Adolescent Psychiatry, 31(4), 640–648.

    Article  CAS  Google Scholar 

  • Weissman, M. M., Gammon, G. D., John, K., Merikangas, K. R., Warner, V., Prusoff, B. A., et al. (1987). Children of depressed parents. Increased psychopathology and early onset of major depression. Archives of General Psychiatry, 44(10), 847–853.

    PubMed  CAS  Google Scholar 

  • Weissman, M. M., Leckman, J. F., Merikangas, K. R., Gammon, G. D., & Prusoff, B. A. (1984). Depression and anxiety disorders in parents and children. Results from the Yale family study. Archives of General Psychiatry, 41(9), 845–852.

    PubMed  CAS  Google Scholar 

  • Weissman, M. M., Wickramaratne, P., Merikangas, K. R., Leckman, J. F., Prusoff, B. A., Caruso, K. A., et al. (1984). Onset of major depression in early adulthood. Increased familial loading and specificity. Archives of General Psychiatry, 41, 1136–1143.

    PubMed  CAS  Google Scholar 

  • Weissman, M. M., Wolk, S., Goldstein, R. B., Moreau, D., Adams, P., Greenwald, S., et al. (1999). Depressed adolescents grown up. JAMA, 281, 1707–1713.

    Article  PubMed  CAS  Google Scholar 

  • Whitbeck, L. B., Hoyt, D. R., Simons, R. L., Conger, R. D., Elder, G. H., Lorenz, F. O., et al. (1992). Intergenerational continuity of parental rejection and depressed affect. Journal of Personality and Social Psychology, 63, 1036–1045.

    Article  PubMed  CAS  Google Scholar 

  • Wickramaratne, P. J., Greenwald, S., & Weissman, M. M. (2000). Psychiatric disorders in the relatives of probands with prepubertal-onset or adolescent-onset major depression. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 1396–1405.

    Article  PubMed  CAS  Google Scholar 

  • Wickramaratne, P. J., Warner, V., & Weissman, M. M. (2000). Selecting early onset MDD probands for genetic studies: Results from a longitudinal high-risk study. American Journal of Medical Genetics, 96, 93–101.

    Article  PubMed  CAS  Google Scholar 

  • Wickramaratne, P. J., & Weissman, M. M. (1998). Onset of psychopathology in offspring by developmental phase and parental depression. Journal of the American Academy of Child Adolescent Psychiatry, 37(9), 933–942.

    Article  CAS  Google Scholar 

  • Woodward, L. J., & Fergusson, D. M. (2001). Life course outcomes of young people with anxiety disorders in adolescence. Journal of the American Academy of Child Adolescent Psychiatry, 40, 1086–1093.

    Article  CAS  Google Scholar 

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Rice, F., Thapar, A. (2009). Depression and Anxiety in Childhood and Adolescence: Developmental Pathways, Genes and Environment. In: Kim, YK. (eds) Handbook of Behavior Genetics. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76727-7_26

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