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Drosophila Model of Alzheimer’s Amyloidosis

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Handbook of Behavior Genetics

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The establishment of animal models of human diseases is crucial for understanding disease pathogenesis as well as for the discovery and evaluation of potential therapies. In the last decades, numerous models of human neurodegenerative diseases have been established in various laboratory organisms. The mouse has been the most popular choice for this purpose and has been used to test many hypotheses derived from in vitro and in vivo observations. In addition to these hypothesis-driven approaches, many groundbreaking discoveries in various biological contexts have been made by non-biased and systematic genome-wide genetic screenings using simple organisms.

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Authors and Affiliations

  1. Laboratory of Neurodegenerative Diseases and Gene Discovery, Farber Institute for Neurosciences, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA

    Koichi Iijima

  2. Laboratory of Neurogenetics and Pathobiology; Farber Institute for Neurosciences; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA

    Kanae Iijima-Ando

  3. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

    Yi Zhong

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  3. Yi Zhong
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Correspondence to Koichi Iijima .

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  1. University of Georgia, Athens, GA, USA

    Yong-Kyu Kim Ph.D

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Iijima, K., Iijima-Ando, K., Zhong, Y. (2009). Drosophila Model of Alzheimer’s Amyloidosis. In: Kim, YK. (eds) Handbook of Behavior Genetics. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76727-7_14

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