Drosophila Model of Alzheimer’s Amyloidosis
The establishment of animal models of human diseases is crucial for understanding disease pathogenesis as well as for the discovery and evaluation of potential therapies. In the last decades, numerous models of human neurodegenerative diseases have been established in various laboratory organisms. The mouse has been the most popular choice for this purpose and has been used to test many hypotheses derived from in vitro and in vivo observations. In addition to these hypothesis-driven approaches, many groundbreaking discoveries in various biological contexts have been made by non-biased and systematic genome-wide genetic screenings using simple organisms.
KeywordsDown Syndrome Amyloid Precursor Protein Cerebral Amyloid Angiopathy Mushroom Body Kenyon Cell
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