Variation in Chicken Gene Structure and Expression Associated with Food-Safety Pathogen Resistance: Integrated Approaches to Salmonella Resistance

  • S.J. Lamont
Part of the Stadler Genetics Symposia Series book series (SGSS)


The use of genetics to enhance immune response and microbial resistance in poultry is an environmentally sound approach to incorporate into comprehensive health programs. Many research strategies can be used to investigate the relationship of host genetics with immune response and disease resistance. Gene discovery to enhance poultry health and food safety should build upon well-defined genetic populations, cell lines, gene identification, genome maps, comparative genomics, and analysis of gene expression. Because each investigative approach has its own shortfalls, the strongest level of confidence comes from the convergence of evidence from an integrated approach of several independent experimental designs, such as whole-genome scans, candidate gene analyses, and functional genomics studies, all supporting the relationship of a specific gene with a resistance or immunity trait. Defining the causal genes, including genomic location and organization, epistatic and pleiotropic effects, and the encoded protein function, opens the door for genetic selection to improve health and also for enhancement of vaccine efficacy and innate immunity. This chapter reviews the rationale and strategies for uncovering genetic resistance to food-safety pathogens in poultry and summarizes successes in elucidating the genetic control of host resistance to Salmonella.


Quantitative Trait Locus Single Nucleotide Polymorphism Quantitative Trait Locus Region Chicken Genome Foodborne Pathogen 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • S.J. Lamont
    • 1
  1. 1.Department of Animal ScienceIowa State UniversityAmesUSA

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