Abstract
The use of genetics to enhance immune response and microbial resistance in poultry is an environmentally sound approach to incorporate into comprehensive health programs. Many research strategies can be used to investigate the relationship of host genetics with immune response and disease resistance. Gene discovery to enhance poultry health and food safety should build upon well-defined genetic populations, cell lines, gene identification, genome maps, comparative genomics, and analysis of gene expression. Because each investigative approach has its own shortfalls, the strongest level of confidence comes from the convergence of evidence from an integrated approach of several independent experimental designs, such as whole-genome scans, candidate gene analyses, and functional genomics studies, all supporting the relationship of a specific gene with a resistance or immunity trait. Defining the causal genes, including genomic location and organization, epistatic and pleiotropic effects, and the encoded protein function, opens the door for genetic selection to improve health and also for enhancement of vaccine efficacy and innate immunity. This chapter reviews the rationale and strategies for uncovering genetic resistance to food-safety pathogens in poultry and summarizes successes in elucidating the genetic control of host resistance to Salmonella.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abasht, B., Dekkers, J.C.M., and Lamont, S.J., 2006, Review of quantitative trait loci identified in the chicken, Poultry Sci. 85:2079–2096.
Beaumont, C., Protais, J., Guillot, J. F., Colin, P., Proux, K., Millet, N., and Pardon, P., 1999, Genetic resistance to mortality of day-old chicks and carrier-state of hens after inoculation with Salmonella enteritidis, Avian Pathol. 28:131–135.
Beaumont, C., Protais, J., Pitel, F., Leveque, G., Malo, D., Lantier, F., Plisson-Petit, F., Colin, P., Protais, M., Le Roy, P., Elsen, J. M., Milan, D., Lantier, I., Neau, A., Salvat, G., and Vignal, A., 2003, Effect of two candidate genes on the Salmonella carrier state in fowl, Poultry Sci. 82:721–726.
Berthelot, F., Beaumont, C., Mompart, F., Girard-Santosuosso, O., Pardon, P., and Duchet-Suchaux, M., 1998, Estimated heritability of the resistance to cecal carrier state of Salmonella enteritidis in chickens, Poultry Sci. 77:797–801.
Biggs, P.M., 1982, The world of poultry diseases, Avian Path. 11:281–300.
Burt, D.W., 2005, Chicken genome: Current status and future opportunities, Genome Res. 15:1692–1698.
Cheeseman, J.H., Kaiser, M.G., Ciraci, C., Kaiser, P., and Lamont, S.J., 2007, Breed effect on early cytokine mRNA expression in spleen and cecum of chickens with and without Salmonella enteritidis infection, Dev. Comp. Immunol. 31:52–60.
Cotter, P.F., Taylor, R.L., Jr., and Abplanalp, H., 1998, B-complex associated immunity to Salmonella enteritidis challenge in congenic chickens, Poultry Sci. 77:1846–1851.
Doyle, M., and Erickson, M.C., 2006, Reducing the carriage of foodborne pathogens in livestock and poultry, Poultry Sci. 85:960–973.
Gast, R.K. and Holt, P.S., 1998, Persistence of Salmonella enteritidis from one day of age until maturity in experimentally infected layer chickens, Poultry Sci. 77:1759–1762.
Girard-Santosuosso, O., Bumstead, N., Lantier, I., Protais, J., Colin, P., Guillot, J.F., Beaumont, C., Malo, D., and Lantier, F., 1997, Partial conservation of the mammalian NRAMP1 syntenic group on chicken chromosome 7, Mamm. Genome 8:614–616.
Girard-Santosuosso, O., Lantier, F., Lantier, I., Bumstead, N., Elsen, J. M., and Beaumont, C., 2002, Heritability of susceptibility to Salmonella enteritidis infection in fowls and test of the role of the chromosome carrying the NRAMP1 gene, Genet. Sel. Evol. 34:211–219.
Hasenstein, J.R., Zhang, G., and Lamont, S.J., 2006, Analyses of five gallinacin genes and the Salmonella enterica serovar Enteritidis response in poultry, Infect. Immun. 74:3375–3380.
Hillier, L.W., Miller, W., Birney, E., Warren, W., Hardison, R.C., et al., 2004, Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution, Nature 432:695–716.
Hocking, P.M., 2005, Review on QTL mapping results in chickens, World’s Poult. Sci. J. 61:215–226.
Hu, J., Bumstead, N., Barrow, P., Sebastiani, G., Olien, L., Morgan, K., and Malo, D., 1997, Resistance to salmonellosis in the chicken is linked to NRAMP1 and TNC, Genome Res. 7:693–704.
Kaiser, M.G., Cheeseman, J.H., Kaiser, P., and Lamont, S.J 2006, Cytokine expression in chicken peripheral blood mononuclear cells after in vitro exposure to Salmonella enterica serovar Enteritidis, Poultry Sci. 85:1907–1911.
Kaiser, M.G., Lakshmanan, N., Wing, T., and Lamont, S.J., 2002, Salmonella enterica serovar enteritidis burden in broiler breeder chicks genetically associated with vaccine antibody response, Avian Dis. 46:25–31.
Kaiser, M.G., and Lamont, S.J., 2002, Microsatellites linked to Salmonella enterica serovar Enteritidis burden in spleen and cecal content of young F1 broiler-cross chicks, Poultry Sci. 81:657–663.
Klasing, K.C., and Korver, D.R., 1997, Leukocytic cytokines regulate growth rate and composition following activation of the immune system, J. Anim. Sci. 75:58–67.
Kaiser, M.G., Wing, T., Cahaner, A., and Lamont, S.J., 1997, Aviagen, 12th International Symposium on Current Problems in Avian Genetics, Prague, Czech Republic.
Kramer, J., Malek, M., and Lamont, S.J., 2003, Association of twelve candidate gene polymorphisms and response to challenge with Salmonella enteritidis in poultry, Anim. Genet. 34:339–348.
Kramer, T.T., Reinke, C.R., and James, M., 1998, Reduction of fecal shedding and egg contamination of Salmonella enteritidis by increasing the number of heterophil adaptations, Avian Dis. 42:585–588.
Lamont, S.J., 1998, Impact of genetics on disease resistance, Poult Sci. 77:1111–1118.
Lamont, S.J., Kaiser, M.G., and Liu, W., 2002, Candidate genes for resistance to Salmonella enteritidis colonization in chickens as detected in a novel genetic cross, Vet. Immunol. Immunop. 87:423–428.
Lamont, S.J., Pinard-van der Laan, M.-H., Cahaner, A., van der Poel, J.J., and Parmentier, H.K., 2003, Selection for disease resistance: direct selection on the immune response, in W.M. Muir and S.E. Aggrey, eds., Poultry Genetics, Breeding and Biotechnology, CAB International, Oxon UK, pp. 399–418.
Leveque, G., Forgetta, V., Morroll, S., Smith, A.L., Bumstead, N., Barrow, P., Loredo-Osti, J.C., Morgan, K., and Malo, D., 2003, Allelic variation in TLR4 is linked to susceptibility to Salmonella enterica serovar Typhimurium infection in chickens, Infect. Immun. 71:1116–1124.
Lillehoj, H.S., Ruff, M.D., Bacon, L.D., Lamont, S.J., and Jeffers, T.K., 1989, Genetic control of immunity to Eimeria tenella. Interaction of MHC genes and non-MHC linked genes influences levels of disease susceptibility in chickens, Vet. Immunol. Immunop. 20:135–148.
Liu, H.C., Cheng, H.H., Tirunagaru, V., Sofer, L., and Burnside, J., 2001, A strategy to identify positional candidate genes conferring Marek’s disease resistance by integrating DNA microarrays and genetic mapping, Anim. Genet. 32:351–359.
Liu, W., Kaiser, M.G., and Lamont, S.J., 2003, Natural resistance-associated macrophage protein 1 gene polymorphisms and response to vaccine against or challenge with Salmonella enteritidis in young chicks, Poultry Sci. 82:259–266.
Liu, W., and Lamont, S.J., 2003, Candidate gene approach: potentional association of caspase-1,inhibitor of apoptosis protein-1, and prosaposin gene polymorphisms with response to Salmonella enteritidis challenge or vaccination in young chicks, Anim. Biotechnol. 14:61–76.
Liu, W., Miller, M. M., and Lamont, S.J., 2002, Association of MHC class I and class II gene polymorphisms with vaccine or challenge response to Salmonella enteritidis in young chicks, Immunogenetics 54:582–590.
Malek, M., Hasenstein, J.R., and Lamont, S.J., 2004, Analysis of chicken TLR4, CD28, MIF,MD-2, and LITAF genes in a Salmonella enteritidis resource population, Poultry Sci. 83:544–549.
Malek, M., and Lamont, S.J., 2003, Association of INOS, TRAIL, TGF-beta2, TGF-beta3, and IgL genes with response to Salmonella enteritidis in poultry, Genet. Sel. Evol. 35 (Suppl 1):S99–S111.
Mariani, P., Barrow, P.A., Cheng, H.H., Groenen, M.M., Negrini, R., and Bumstead, N., 2001, Localization to chicken chromosome 5 of a novel locus determining salmonellosis resistance, Immunogenetics 53:786–791.
McElroy, J.P., Dekkers, J.C.M., Fulton, J.E., O’Sullivan, N.P., Soller, M., Lipkin, E., Zhang, W., Koehler, K.J., Lamont, S.J., and Cheng, H.H., 2005, Microsatellite markers associated with resistance to Marek’s disease in commercial layer chickens, Poultry Sci. 84:1678–1688.
Morgan, R.W., Sofer, L., Anderson, A.S., Bernberg, E.L., Cui, J., and Burnside, J., 2001, Induction of host gene expression following infection of chicken embryo fibroblasts with oncogenic Marek’s disease virus, J. Virol. 75:533–539.
Tilquin, P., Barrow, P.A., Marly, J., Pitel, F., Plisson-Petit, F., Velge, P., Vignal, A., Baret, P.V., Bumstead, N., and Beaumont, C., 2005, A genome scan for quantitative trait loci affecting the Salmonella carrier-state in the chicken, Genet. Sel. Evol. 37:539–561.
Wong, G.K., Liu, B., Wang, J., Zhang, Y., Yang, X., et al., 2004, A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms, Nature 432:717–722.
Yonash, N., Bacon, L.D., Witter, R.L., and Cheng, H.H., 1999, High resolution mapping and identification of new quantitative trait loci (QTL) affecting susceptibility to Marek’s disease, Anim. Genet. 30:126–135.
Zhou, H., and Lamont, S.J., 2007, Global gene expression profile after Salmonella enterica Serovar enteritidis challenge in two F8 advanced intercross chicken lines. Cytogenet, Genome Res. 117:131–138.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Lamont, S. (2008). Variation in Chicken Gene Structure and Expression Associated with Food-Safety Pathogen Resistance: Integrated Approaches to Salmonella Resistance. In: Gustafson, J., Taylor, J., Stacey, G. (eds) Genomics of Disease. Stadler Genetics Symposia Series. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76723-9_5
Download citation
DOI: https://doi.org/10.1007/978-0-387-76723-9_5
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-76722-2
Online ISBN: 978-0-387-76723-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)