DNA Metallo-Intercalators with Leishmanicidal Activity

Part of the Molecular Biology Intelligence Unit book series (MBIU)


In the present chapter we focus our attention on the use of metal complexes for the treatment of leishmaniasis, especially those that have leishmanicidal activity which could be associated with their interaction with the parasitic DNA. Furthermore, we revise current knowledge of leishmaniasis, including PCD-inducing drugs used clinically and those currently in the experimental and evaluation phases.


Visceral Leishmaniasis Antimicrob Agent Cutaneous Leishmaniasis Leishmania Species Sterol Biosynthesis 


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • Maribel Navarro
    • 1
  • Gonzalo Visbal
    • 2
  • Edgar Marchán
    • 2
  1. 1.Instituto Venezolano de Investigaciones Científicas (IVIC), Carretera PanamericanaCentro de QuímicaCaracasVenezuela
  2. 2.Laboratorio de Síntesis Orgánica y Productos Naturales Centro de QuímicaInstituto Venezolano de Investigaciones Científicas (IVIC)CaracasVenezuela

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