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DNA Metallo-Intercalators with Leishmanicidal Activity

  • Chapter
Programmed Cell Death in Protozoa

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

In the present chapter we focus our attention on the use of metal complexes for the treatment of leishmaniasis, especially those that have leishmanicidal activity which could be associated with their interaction with the parasitic DNA. Furthermore, we revise current knowledge of leishmaniasis, including PCD-inducing drugs used clinically and those currently in the experimental and evaluation phases.

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Authors and Affiliations

  1. Instituto Venezolano de Investigaciones Científicas (IVIC), Carretera Panamericana, Centro de Química, KM 11, Altos de Pipe, Caracas, 1020-A, Venezuela

    Maribel Navarro

  2. Laboratorio de Síntesis Orgánica y Productos Naturales Centro de Química, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela

    Gonzalo Visbal & Edgar Marchán

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  1. Maribel Navarro
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  2. Gonzalo Visbal
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Correspondence to Maribel Navarro .

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Navarro, M., Visbal, G., Marchán, E. (2008). DNA Metallo-Intercalators with Leishmanicidal Activity. In: Programmed Cell Death in Protozoa. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76717-8_6

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