Programmed Cell Death in Protozoa: An Evolutionary Point of View. The Example of Kinetoplastid Parasites
Programmed cell death (PCD) is a molecular event which plays an essential role in the development of multicellular organisms. However, recent studies indicate that PCD is a mechanism also present in protozoa and unicellular eukaryotes. For instance, it has been recently proposed that some Trypanosomatid parasites have a PCD mechanism descendant from an ancient life form that has actually evolved. Thus, two hypotheses may explain the existence of PCD in protozoa such as Trypanosomatids. First, PCD could simply be a process without a defined function inherited through cell evolution, which is triggered in response to diverse stimuli and stress conditions. Alternatively, PCD might be used by Trypanosomatids as a control mechanism to maximize their biological fitness.
KeywordsProgramme Cell Death Multicellular Organism Trypanosoma Cruzi Trypanosoma Brucei Cell Death Differ
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- 2.World Health Organization The World Health report: life in the 21st century. A vision for all. Report of the Director-General, WHO, Geneva, 1998:44–51.Google Scholar
- 9.Ameisen JC, Idziorek T, Billaut-Mulot O et al. Apoptosis in a unicellular eukaryote (Trypanosoma cruzi): implications for the evolutionary origin and role of programmed cell death in the control of cell proliferation, differentiation and survival. Cell Death Differ 1995; 2:285–300.PubMedGoogle Scholar
- 12.Margulis L. Symbiotic theory of the origin of eukaryotic organelles. Jenning DH, Leed DL, eds. Symbiosis. Symposium 29: Society for Experimental Biology. Cambridge: Cambridge University Press, 1975:21–38.Google Scholar
- 13.Gray MW. Origin and evolution of mitochondrial DNA. Annu Rev Biochem 1989; 5:25–50.Google Scholar
- 18.Raff M. Social control of cell survival and cell death. Nature 1994; 365:397–400.Google Scholar