The Role of Cell Adhesion Molecules in Axon Growth and Guidance

  • Hiroyuki Kamiguchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 621)


During development, axons elongate along the correct path toward their final targets. Growing axons maintain adhesive interactions with specific environmental cues via cell adhesion molecules (CAMs). The axon-environment adhesion must be dynamically controlled, both temporally and spatially, to enable the axons to navigate and migrate correctly. In this way, CAMs play a central role in mediating contact-dependent regulation of motile behavior of the axons. This chapter examines the mechanisms underlying how CAMs control axon growth and guidance, with a particular focus on intracellular signaling, trafficking, and interactions with the actin cytoskeleton.


Focal Adhesion Kinase Growth Cone Fibroblast Growth Factor Receptor Neural Cell Adhesion Molecule Axon Guidance 


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Hiroyuki Kamiguchi
    • 1
  1. 1.Laboratory for Neuronal Growth MechanismsRIKEN Brain Science InstituteWako, SaitamaJapan

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