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The Role of Cell Adhesion Molecules in Axon Growth and Guidance

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Axon Growth and Guidance

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 621))

Abstract

During development, axons elongate along the correct path toward their final targets. Growing axons maintain adhesive interactions with specific environmental cues via cell adhesion molecules (CAMs). The axon-environment adhesion must be dynamically controlled, both temporally and spatially, to enable the axons to navigate and migrate correctly. In this way, CAMs play a central role in mediating contact-dependent regulation of motile behavior of the axons. This chapter examines the mechanisms underlying how CAMs control axon growth and guidance, with a particular focus on intracellular signaling, trafficking, and interactions with the actin cytoskeleton.

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Authors and Affiliations

  1. Laboratory for Neuronal Growth Mechanisms, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    Hiroyuki Kamiguchi

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  1. Hiroyuki Kamiguchi
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  1. Laboratoire de Neurobiologie du Developpement et de la Regeneration (LNDR), Centre de Neurochimie de CNRS, Strasbourg, France

    Dominique Bagnard Ph.D.

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Kamiguchi, H. (2007). The Role of Cell Adhesion Molecules in Axon Growth and Guidance. In: Bagnard, D. (eds) Axon Growth and Guidance. Advances in Experimental Medicine and Biology, vol 621. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76715-4_7

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