Neurotrophic Factors: Are They Axon Guidance Molecules?

  • Sarah Guthrie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 621)


Neurotrophic factors play a multiplicity of roles during development. They can promote axonal growth in vitro and are capable of orienting axons. Recently, molecular evidence suggests that neurotrophic factors and axon guidance molecules reglate the same signalling pathways in neurons. Yet only a few critical studies have tested a possible role for neurotrophic factors as guidance molecules in vivo. In this chapter I review the evidence for and against neurotrophic factors as axon guidance molecules.


Nerve Growth Factor Neurotrophic Factor Hepatocyte Growth Factor Sensory Neuron Growth Cone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Sarah Guthrie
    • 1
  1. 1.Centre for Developmental NeurobiologyKing’s College LondonLondonUK

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