The Role of Cyclic Nucleotides in Axon Guidance

  • Michael Piper
  • Francis van Horck
  • Christine Holt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 621)


During the formation of the nervous system, axonal growth cones navigate through the complex environment of the developing embryo to innervate their targets. Growth cones achieve this formidable feat by responding to attractive or repulsive guidance cues expressed at specific points along the trajectory of their growth, which impart the directional information required for accurate pathfinding. While much is known about guidance molecules and their receptors, many questions remain unanswered. Which signal transduction pathways are activated within the growth cone after encountering a guidance cue? How is this related to rearrangement of the growth cone cytoskeleton? Do different cues use different signal transduction pathways? This chapter will review some of the work that has addressed these fundamental question, with a specific focus on the role of the cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), in axon guidance.


Dorsal Root Ganglion Adenylyl Cyclase Growth Cone Cyclic Nucleotide Axon Guidance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Michael Piper
    • 1
  • Francis van Horck
    • 1
  • Christine Holt
    • 1
  1. 1.Department of AnatomyUniversity of CambridgeCambridgeUK

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