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Axon Growth and Guidance pp 1–16Cite as

Molecular Mechanisms of Axonal Growth

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 621))

Abstract

Outgrowth of axons during neuronal development, as well as their regeneration after injury, of the adult nervous system is controlled by specific extracellular cues which are diffusible, or bound to cell membranes or extracellular matrix. The exact molecular mechanisms through which these extracellular signals are integrated by the growing axon, are not yet well defined. However, it is widely accepted that most, if not all, signaling cascades triggered by guidance cues eventually converge onto the cytoskeleton. The action of extracellular guidance factors is thus modulated not only by specific membrane receptors, but also by cytoskeletal and cytoskeleton-associated molecules within the axon. In fact, the cytoskeleton represents a point of convergence and integration of both neuron-intrinsic and extrinsic factors. Moreover, in recent years, there has been increasing evidence for the involvement of a coordinated cross-talk between actin filaments and microtubules, the two main components of the growth cone cytoskeleton. Their reorganization is complex and involves numerous cytoskeleton-associated proteins whose function is regulated via activation or inhibition of particular signaling pathways 1–4.

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References

  1. Zhou FQ, Cohan CS. How actin filaments and microtubules steer growth cones to their targets. J Neurobiol 2004; 58:84–91.

    Article  PubMed  CAS  Google Scholar 

  2. Rodriguez OC, Schaefer AW, Mandato CA et al. Conserved microtubule-actin interactions in cell movement and morphogenesis. Nat Cell Biol 2003; 5:599–609.

    Article  PubMed  CAS  Google Scholar 

  3. Kodama A, Lechler T, Fuchs E. Coordinating cytoskeletal tracks to polarize cellular movements. J Cell Biol 2004; 167:203–7.

    Article  PubMed  CAS  Google Scholar 

  4. Baas PW, Luo L. Signaling at the growth cone: The scientific progeny of Cajal meet in Madrid. Neuron 2001; 32:981–4.

    Article  PubMed  CAS  Google Scholar 

  5. Suter DM, Forscher P. Substrate-cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidance. J Neurobiol 2000; 44:97–113.

    Article  PubMed  CAS  Google Scholar 

  6. Kornack DR, Giger RJ. Probing microtubule+TIPs: Regulation of axon branching. Curr Opin Neurobiol 2005; 15:58–66.

    Article  PubMed  CAS  Google Scholar 

  7. Gungabissoon RA, Bamburg JR. Regulation of growth cone actin dynamics by ADF/cofilin. J Histochem Cytochem 2003; 51:411–20.

    PubMed  CAS  Google Scholar 

  8. Dehmelt L, Halpain S. Actin and microtubules in neurite initiation: Are MAPs the missing link? J Neurobiol 2004; 58:18–33.

    Article  PubMed  CAS  Google Scholar 

  9. Letourneau PC. Differences in the organization of actin in the growth cones compared with the neurites of cultured neurons from chick embryos. J Cell Biol 1983; 97:963–73.

    Article  PubMed  CAS  Google Scholar 

  10. Bridgman PC, Dailey ME. The organization of myosin and actin in rapid frozen nerve growth cones. J Cell Biol 1989; 108:95–109.

    Article  PubMed  CAS  Google Scholar 

  11. Schaefer AW, Kabir N, Forscher P. Filopodia and actin arcs guide the assembly and transport of two populations of microtubules with unique dynamic parameters in neuronal growth cones. J Cell Biol 2002; 158:139–52.

    Article  PubMed  CAS  Google Scholar 

  12. Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003; 112:453–65.

    Article  PubMed  CAS  Google Scholar 

  13. Forscher P, Smith SJ. Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone. J Cell Biol 1988; 107:1505–16.

    Article  PubMed  CAS  Google Scholar 

  14. Lewis AK, Bridgman PC. Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity. J Cell Biol 1992; 119:1219–43.

    Article  PubMed  CAS  Google Scholar 

  15. Brown J, Bridgman PC. Role of myosin II in axon outgrowth. J Histochem Cytochem 2003; 51:421–8.

    PubMed  CAS  Google Scholar 

  16. Dent EW, Gertler FB. Cytoskeletal dynamics and transport in growth cone motility and axon guidance. Neuron 2003; 40:209–27.

    Article  PubMed  CAS  Google Scholar 

  17. Millard TH, Sharp SJ, Machesky LM. Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex. Biochem J 2004; 380:1–17.

    Article  PubMed  CAS  Google Scholar 

  18. Kovar DR. Molecular details of formin-mediated actin assembly. Curr Opin Cell Biol 2006; 18:11–7.

    Article  PubMed  CAS  Google Scholar 

  19. Huang TY, DerMardirossian C, Bokoch GM. Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol 2006; 18:26–31.

    Article  PubMed  CAS  Google Scholar 

  20. McGough AM, Staiger CJ, Min JK et al. The gelsolin family of actin regulatory proteins: Modular structures, versatile functions. FEBS Lett 2003; 552:75–81.

    Article  PubMed  CAS  Google Scholar 

  21. Luduena RF. Multiple forms of tubulin: Different gene products and covalent modifications. Int Rev Cytol 1998; 178:207–75.

    Article  PubMed  CAS  Google Scholar 

  22. Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature 1984; 312:237–42.

    Article  PubMed  CAS  Google Scholar 

  23. Baas PW. Microtubules and axonal growth. Curr Opin Cell Biol 1997; 9:29–36.

    Article  PubMed  CAS  Google Scholar 

  24. Tanaka EM, Kirschner MW. Microtubule behavior in the growth cones of living neurons during axon elongation. J Cell Biol 1991; 115:345–63.

    Article  PubMed  CAS  Google Scholar 

  25. Dent EW, Kalil K. Axon branching requires interactions between dynamic microtubules and actin filaments. J Neurosci 2001; 21:9757–69.

    PubMed  CAS  Google Scholar 

  26. Gordon-Weeks PR. Growth cones: The mechanism of neurite advance. Bioessays 1991; 13:235–9.

    Article  PubMed  CAS  Google Scholar 

  27. Tanaka E, Ho T, Kirschner MW. The role of microtubule dynamics in growth cone motility and axonal growth. J Cell Biol 1995; 128:139–55.

    Article  PubMed  CAS  Google Scholar 

  28. Tanaka E, Kirschner MW. The role of microtubules in growth cone turning at substrate boundaries. J Cell Biol 1995; 128:127–37.

    Article  PubMed  CAS  Google Scholar 

  29. Buck KB, Zheng JQ. Growth cone turning induced by direct local modification of microtubule dynamics. J Neurosci 2002; 22:9358–67.

    PubMed  CAS  Google Scholar 

  30. Mack TG, Koester MP, Pollerberg GE. The microtubule-associated protein MAP1B is involved in local stabilization of turning growth cones. Mol Cell Neurosci 2000; 15:51–65.

    Article  PubMed  CAS  Google Scholar 

  31. Baas PW, Ahmad FJ, Pienkowski TP et al. Sites of microtubule stabilization for the axon. J Neurosci 1993; 13:2177–85.

    PubMed  CAS  Google Scholar 

  32. Khawaja S, Gundersen GG, Bulinski JC. Enhanced stability of microtubules enriched in detyrosinated tubulin is not a direct function of detyrosination level. J Cell Biol 1988; 106:141–9.

    Article  PubMed  CAS  Google Scholar 

  33. Erck C, Peris L, Andrieux A et al. A vital role of tubulin-tyrosine-ligase for neuronal organization. Proc Natl Acad Sci USA 2005; 102:7853–8.

    Article  PubMed  CAS  Google Scholar 

  34. Bonnet C, Boucher D, Lazereg S et al. Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation. J Biol Chem 2001; 276:12839–48.

    Article  PubMed  CAS  Google Scholar 

  35. Goold RG, Owen R, Gordon-Weeks PR. Glycogen synthase kinase 3beta phosphorylation of microtubule-associated protein 1B regulates the stability of microtubules in growth cones. J Cell Sci 1999; 112(Pt 19):3373–84.

    PubMed  CAS  Google Scholar 

  36. Gelfand VI, Bershadsky AD. Microtubule dynamics: Mechanism, Regulation, and function. Annu Rev Cell Biol 1991; 7:93–116.

    Article  PubMed  CAS  Google Scholar 

  37. Matus A. Microtubule-associated proteins: Their potential role in determining neuronal morphology. Annu Rev Neurosci 1988; 11:29–44.

    Article  PubMed  CAS  Google Scholar 

  38. Gordon-Weeks PR, Fischer I. MAP1B expression and microtubule stability in growing and regenerating axons. Microsc Res Tech 2000; 48:63–74.

    Article  PubMed  CAS  Google Scholar 

  39. Matus A. Microtubule-associated proteins and neuronal morphogenesis. J Cell Sci Suppl 1991; 15:61–7.

    PubMed  CAS  Google Scholar 

  40. Hirokawa N. Microtubule organization and dynamics dependent on microtubule-associated proteins. Curr Opin Cell Biol 1994; 6:74–81.

    Article  PubMed  CAS  Google Scholar 

  41. Takei Y, Teng J, Harada A et al. Defects in axonal elongation and neuronal migration in mice with disrupted tau and map 1b genes. J Cell Biol 2000; 150:989–1000.

    Article  PubMed  CAS  Google Scholar 

  42. Takei Y, Kondo S, Harada A et al. Delayed development of nervous system in mice homozygous for disrupted microtubule-associated protein 1B (MAP1B) gene. J Cell Biol 1997; 137:1615–26.

    Article  PubMed  CAS  Google Scholar 

  43. Gonzalez-Billault C, Owen R, Gordon-Weeks PR et al. Microtubule-associated protein 1B is involved in the initial stages of axonogenesis in peripheral nervous system cultured neurons. Brain Res 2002; 943:56–67.

    Article  PubMed  CAS  Google Scholar 

  44. DiTella MC, Feiguin F, Carri N et al. MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth. J Cell Sci 1996; 109:467–77.

    PubMed  CAS  Google Scholar 

  45. Bouquet C, Soares S, von Boxberg Y et al. Microtubule-associated protein 1B controls directionality of growth cone migration and axonal branching in regeneration of adult dorsal root ganglia neurons. J Neurosci 2004; 24:7204–13.

    Article  PubMed  CAS  Google Scholar 

  46. Riederer BM, Pellier V, Antonsson B et al. Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10. Proc Natl Acad Sci USA 1997; 94:741–5.

    Article  PubMed  CAS  Google Scholar 

  47. Belmont LD, Mitchison TJ. Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules. Cell 1996; 84:623–31.

    Article  PubMed  CAS  Google Scholar 

  48. Grenningloh G, Soehrman S, Bondallaz P et al. Role of the microtubule destabilizing proteins SCG10 and stathmin in neuronal growth. J Neurobiol 2004; 58:60–9.

    Article  PubMed  CAS  Google Scholar 

  49. Tanaka E, Sabry J. Making the connection: Cytoskeletal rearrangements during growth cone guidance. Cell 1995; 83:171–6.

    Article  PubMed  CAS  Google Scholar 

  50. Stepanova T, Slemmer J, Hoogenraad CC et al. Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein). J Neurosci 2003; 23:2655–64.

    PubMed  CAS  Google Scholar 

  51. Galjart N. CLIPs and CLASPs and cellular dynamics. Nat Rev Mol Cell Biol 2005; 6:487–98

    Article  PubMed  CAS  Google Scholar 

  52. Jimenez-Mateos EM, Paglini G, Gonzalez-Billault C et al. End binding protein-1 (EB1) complements microtubule-associated protein-1B during axonogenesis. J Neurosci Res 2005; 80:350–9.

    Article  PubMed  CAS  Google Scholar 

  53. Lee MK, Cleveland DW. Neuronal intermediate filaments. Annu Rev Neurosci 1996; 19:187–217.

    Article  PubMed  CAS  Google Scholar 

  54. Gallant PE. Axonal protein synthesis and transport. J Neurocytol 2000; 29:779–82.

    Article  PubMed  CAS  Google Scholar 

  55. Eyer J, Peterson A. Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein. Neuron 1994; 12:389–405.

    Article  PubMed  CAS  Google Scholar 

  56. Baas PW, Ahmad FJ. Force generation by cytoskeletal motor proteins as a regulator of axonal elongation and retraction. Trends Cell Biol 2001; 11:244–9.

    Article  PubMed  CAS  Google Scholar 

  57. Hirokawa N, Takemura R. Molecular motors in neuronal development, intracellular transport and diseases. Curr Opin Neurobiol 2004; 14:564–73.

    Article  PubMed  CAS  Google Scholar 

  58. Medeiros NA, Burnette DT, Forscher P. Myosin II functions in actin-bundle turnover in neuronal growth cones. Nat Cell Biol 2006; 8:215–26.

    Article  PubMed  CAS  Google Scholar 

  59. Lee SK, Hollenbeck PJ. Organization and translation of mRNA in sympathetic axons. J Cell Sci 2003; 116:4467–78.

    Article  PubMed  CAS  Google Scholar 

  60. Zheng JQ, Kelly TK, Chang B et al. A functional role for intra-axonal protein synthesis during axonal regeneration from adult sensory neurons. J Neurosci 2001; 21:9291–303.

    PubMed  CAS  Google Scholar 

  61. Hanz S, Perlson E, Willis D et al. Axoplasmic importins enable retrograde injury signaling in lesioned nerve. Neuron 2003; 40:1095–104.

    Article  PubMed  CAS  Google Scholar 

  62. Willis, D, Li KW, Zheng JQ et al. Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein, mRNAs in axons. J Neurosci 2005; 25:778–91.

    Article  PubMed  CAS  Google Scholar 

  63. Ming GL, Wong ST, Henley J et al. Adaptation in the chemotactic guidance of nerve growth cones. Nature 2002; 417:411–8.

    Article  PubMed  CAS  Google Scholar 

  64. Wujek JR, Lasek RJ. Correlation of axonal regeneration and slow component B in two branches of a single axon. J Neurosci 1983; 3:243–51.

    PubMed  CAS  Google Scholar 

  65. Galbraith JA, Gallant PE. Axonal transport of tubulin and actin. J Neurocytol 2000; 29:889–911.

    Article  PubMed  CAS  Google Scholar 

  66. Wang L, Brown A. Rapid movement of microtubules in axons. Curr Biol 2002; 12:1496–1501.

    Article  PubMed  CAS  Google Scholar 

  67. He Y, Francis F, Myers KA et al. Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments. J Cell Biol 2005; 168:697–703.

    Article  PubMed  CAS  Google Scholar 

  68. Baas PW, Buster DW. Slow axonal transport and the genesis of neuronal morphology. J Neurobiol 2004; 58:3–17.

    Article  PubMed  CAS  Google Scholar 

  69. Gallo G, Letourneau PC. Neurotrophins and the dynamic regulation of the neuronal cytoskeleton. J Neurobiol 2000; 44:159–73.

    Article  PubMed  CAS  Google Scholar 

  70. Gallo G, Letourneau PC. Axon guidance: GTPases help axons reach their targets. Curr Biol 8:R80–2.

    Google Scholar 

  71. Challacombe JF, Snow DM, Letourneau PC. Dynamic microtubule ends are required for growth cone turning to avoid an inhibitory guidance cue. J Neurosci 1997; 17:3085–95.

    PubMed  CAS  Google Scholar 

  72. Gallo G, Letourneau PC. Different contributions of microtubule dynamics, and transport to the growth of axons and collateral sprouts. J Neurosci 1999; 19:3860–73.

    PubMed  CAS  Google Scholar 

  73. Hall A. Rho GTPases and the actin cytoskeleton. Science 1998; 279:509–14.

    Article  PubMed  CAS  Google Scholar 

  74. Luo L. Rho GTPases in neuronal morphogenesis. Nat Rev Neurosci 2000; 1:173–80.

    Article  PubMed  CAS  Google Scholar 

  75. Luo L. Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. Annu Rev Cell Dev Biol 2002; 18:601–35.

    Article  PubMed  CAS  Google Scholar 

  76. Moon SY, Zheng Y. Rho GTPase-activating proteins in cell regulation. Trends Cell Biol 2003; 13:13–22.

    Article  PubMed  CAS  Google Scholar 

  77. Schmidt A, Hall A. Guanine nucleotide exchange factors for Rho GTPases: Turning on the switch. Genes Dev 2002; 16:1587–609.

    Article  PubMed  CAS  Google Scholar 

  78. Manganello JM, Huang JS, Kozasa T et al. Protein kinase A-mediated phosphorylation of the Galpha 13 switch I region alters the Galphabetagamma 13-G protein-coupled receptor complex and inhibits Rho activation. J Biol Chem 2003; 278:124–30.

    Article  PubMed  CAS  Google Scholar 

  79. Ellerbroek SM, Wennerberg K, Burridge K. Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem 2003; 278: 19023–31.

    Article  PubMed  CAS  Google Scholar 

  80. Feoktistov I, Goldstein AE, Biaggioni I. Cyclic AMP and protein kinase A stimulate Cdc42: Role of A(2) adenosine receptors in human mast cells. Mol Pharmacol 2000; 58:903–10.

    PubMed  CAS  Google Scholar 

  81. O’Connor KL, Mercurio AM. Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells. J Biol Chem 2001; 276:47895–900.

    PubMed  CAS  Google Scholar 

  82. Brambilla R, Schnapp A, Casagranda F et al. Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases. EMBO J 1995; 14:3116–26.

    PubMed  CAS  Google Scholar 

  83. Bruckner K, Klein R. Signaling by Eph receptors and their ephrin ligands. Curr Opin Neurobiol 1998; 8:375–82.

    Article  PubMed  CAS  Google Scholar 

  84. Wahl S, Barth H, Ciossek T et al. Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J Cell Biol 2000; 149:263–70.

    Article  PubMed  CAS  Google Scholar 

  85. Hu H, Marton TF, Goodman CS. Plexin B mediates axon guidance in Drosophila, by simultaneously inhibiting active Rac and enhancing RhoA signaling. Neuron 2001; 32:39–51.

    Article  PubMed  CAS  Google Scholar 

  86. Ozdinler PH, Erzurumlu RS. Regulation of neurotrophin-induced axonal responses via Rho GTPases. J Comp Neurol 2001; 438:377–87.

    Article  PubMed  CAS  Google Scholar 

  87. Yamauchi J, Chan JR, Miyamoto Y et al. The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor, Dbs to enhance Schwann cell migration. Proc Natl Acad Sci USA 2005; 102:5198–203.

    Article  PubMed  CAS  Google Scholar 

  88. Yamashita T, Tucker KL, Barde YA. Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth. Neuron 24:585–93.

    Google Scholar 

  89. Loudon R, Silver LD, Yee Jr HF et al. RhoA-kinase and myosin II are required for the maintenance of growth cone polarity and guidance by nerve growth factor. J Neurobiol 2006; 66:847–67.

    Article  PubMed  CAS  Google Scholar 

  90. Rohatgi R, Ma L, Miki H et al. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 1999; 97:221–31.

    Article  PubMed  CAS  Google Scholar 

  91. Welch MD, Mullins RD. Cellular control of actin nucleation. Annu Rev Cell Dev Biol 2002; 18:247–88.

    Article  PubMed  CAS  Google Scholar 

  92. Miki H, Yamaguchi H, Suetsugu S et al. IRS p53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature 2000; 408:732–5.

    Article  PubMed  CAS  Google Scholar 

  93. Arber S, Barbayannis FA, Hanser H et al. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 1998; 393:805–9.

    Article  PubMed  CAS  Google Scholar 

  94. Edwards DC, Sanders LC, Bokoch GM et al. Activation of LIM-kinase by Pakl couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol 1999; 1:253–9.

    Article  PubMed  CAS  Google Scholar 

  95. Hsieh SH, Ferraro GB, Fournier AE. Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase. J Neurosci 2006; 26:1006–15.

    Article  PubMed  CAS  Google Scholar 

  96. Hirose M, Ishizaki T, Watanabe N et al. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J Cell Biol 1998; 141:1625–36.

    Article  PubMed  CAS  Google Scholar 

  97. Amano M, Chihara K, Nakamura N et al. Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase. Genes Cells 1998; 3:177–88.

    Article  PubMed  CAS  Google Scholar 

  98. Pruyne D, Evangelista M, Yang C et al. Role of formins in actin assembly: Nucleation and barbed-end association. Science 2002; 297:612–5.

    Article  PubMed  CAS  Google Scholar 

  99. Palazzo AF, Cook TA, Alberts AS et al. mDia mediates Rho-regulated formation and orientation of stable microtubules. Nat Cell Biol 2001; 3:723–9.

    Article  PubMed  CAS  Google Scholar 

  100. Daub H, Gevaert K, Vandekerckhove J et al. Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16. J Biol Chem 2001; 276:1677–80.

    Article  PubMed  CAS  Google Scholar 

  101. Wittmann T, Waterman-Storer CM. Cell motility: Can Rho GTPases and microtubules point the way? J Cell Sci 2001; 114:3795–803.

    PubMed  CAS  Google Scholar 

  102. Sayas CL, Avila J, Wandosell F. Glycogen synthase kinase-3 is activated in neuronal cells by Galpha 12 and Galpha 13 by Rho-independent and Rho-dependent mechanisms. J Neurosci 2002; 22:6863–75.

    PubMed  CAS  Google Scholar 

  103. Krendel M, Zenke FT, Bokoch GM. Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Nat Cell Biol 2002; 4:294–301.

    Article  PubMed  CAS  Google Scholar 

  104. Waterman-Storer CM, Worthylake RA, Liu BP et al. Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts. Nat Cell Biol 1999; 1:45–50.

    Article  PubMed  CAS  Google Scholar 

  105. Zhou FQ, Waterman-Storer CM, Cohan CS. Focal loss of actin bundles causes microtubule redistribution and growth cone turning. J Cell Biol 2002; 157:839–49.

    Article  PubMed  CAS  Google Scholar 

  106. Challacombe JF, Snow DM, Letourneau PC. Actin filament bundles are required for microtubule reorientation during growth cone turning to avoid an inhibitory guidance cue. J Cell Sci 1996; 109:2031–40.

    PubMed  CAS  Google Scholar 

  107. Owen R, Gordon-Weeks PR. Inhibition of glycogen synthase kinase 3beta in sensory neurons in culture alters filopodia dynamics and microtubule distribution in growth cones. Mol Cell Neurosci 2003; 23:626–37.

    Article  PubMed  CAS  Google Scholar 

  108. Ziv NE, Spira ME. Induction of growth cone formation by transient and localized increases of intracellular proteolytic activity. J Cell Biol 1998; 140:223–32.

    Article  PubMed  CAS  Google Scholar 

  109. Spira ME, Oren R, Dormann A et al. Critical calpain-dependent ultrastructural alterations underlie the transformation of an axonal segment into a growth cone after axotomy of cultured Aplysia neurons. J Comp Neurol 2003; 457: 293–312.

    Article  PubMed  Google Scholar 

  110. Hoffman PN, Cleveland DW. Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: Induction of a specific beta-tubulin isotype. Proc Natl Acad Sci USA 1988; 85:4530–3.

    Article  PubMed  CAS  Google Scholar 

  111. Hoffman PN, Thompson GW, Griffin JW Changes in neurofilament transport coincide temporally with alterations in the caliber of axons in regenerating motor fibers. J Cell Biol 1985; 101:1332–40.

    Article  PubMed  CAS  Google Scholar 

  112. Tetzlaff W, Leonard C, Krekoski CA et al. Reductions in motoneuronal neurofilament synthesis by successive axotomies: A possible explanation for the conditioning lesion effect on axon regeneration. Exp Neurol 1996; 139:95–106.

    Article  PubMed  CAS  Google Scholar 

  113. Tetzlaff W, Alexander SW, Miller FD et al. Response of facial and rubrospinal neurons to axotomy: Changes in mRNA expression for cytoskeletal proteins and GAP-43. J Neurosci 1991; 11:2528–44.

    PubMed  CAS  Google Scholar 

  114. Domeniconi M, Filbin MT. Overcoming inhibitors in myelin to promote axonal regeneration. J Neurol Sci 2005; 233:43–7.

    Article  PubMed  CAS  Google Scholar 

  115. Qiu J, Cai D, Dai H et al. Spinal axon regeneration induced by elevation of cyclic AMP. Neuron 2002; 34:895–903.

    Article  PubMed  CAS  Google Scholar 

  116. Neumann S, Bradke F, Tessier-Lavigne M et al. Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation. Neuron 2002 34:885–93.

    Article  PubMed  CAS  Google Scholar 

  117. Cai D, Qiu J, Cao Z et al. Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J Neurosci 2001; 21:4731–9.

    PubMed  CAS  Google Scholar 

  118. Fournier AE, Takizawa BT, Strittmatter SM. Rho kinase inhibition enhances, axonal regeneration in the injured CNS. J Neurosci 2003; 23:1416–23.

    PubMed  CAS  Google Scholar 

  119. Niederost B, Oertle T, Fritsche J et al. Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1. J Neurosci 2002; 22:10368–76.

    PubMed  CAS  Google Scholar 

  120. Mimura F, Yamagishi S, Arimura N et al. Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism. J Biol Chem 2006; 281:15970–9.

    Article  PubMed  CAS  Google Scholar 

  121. Gao Y, Deng K, Hou J et al. Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo. Neuron 2004; 44:609–21.

    Article  PubMed  CAS  Google Scholar 

  122. Cai D, Deng K, Mellado W et al. Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro. Neuron 2002; 35:711–9.

    Article  PubMed  CAS  Google Scholar 

  123. Skene JH. Axonal growth-associated proteins. Annu Rev Neurosci 1989; 12:127–56.

    Article  PubMed  CAS  Google Scholar 

  124. Bomze HM, Bulsara KR, Iskandar BJ et al. Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons. Nat Neurosci 2001; 4:38–43.

    Article  PubMed  CAS  Google Scholar 

  125. Ma D, Nothias F, Boyne LJ et al. Differential regulation of microtubule-associated protein 1B (MAP1B) in rat CNS and PNS during development. J Neurosci Res 1997; 49:319–32.

    Article  PubMed  CAS  Google Scholar 

  126. Ma D, Connors T, Nothias F. et al. Regulation of the expression and phosphorylation of microtubule-associated protein 1B during regeneration, of adult dorsal root ganglion neurons. Neuroscience 2000; 99:157–70.

    Article  PubMed  CAS  Google Scholar 

  127. Nothias F, Vernier P, von Boxberg Y et al. Modulation of NCAM polysialylation is associated with morphofunctional modifications in the hypothalamo-neurohypophysial system during lactation. Eur J Neurosci 1997; 9:1553–65.

    Article  PubMed  CAS  Google Scholar 

  128. Nothias F, Fischer I, Murray M et al. Expression of a phosphorylated isoform of MAP1B is maintained in adult central nervous system areas that retain capacity for structural plasticity. J Comp Neurol 1996; 368:317–34.

    Article  PubMed  CAS  Google Scholar 

  129. Soares S, von Boxberg Y, Lombard MC et al. Phosphorylated MAP1B is induced in central sprouting of primary afferents in response to peripheral injury but not in response to rhizotomy. Eur J Neurosci 2002; 16:593–606.

    Article  PubMed  Google Scholar 

  130. Soares S, Fischer I, Ravaille-Veron M. Induction of MAP1B phosphorylation in target-deprived afferent fibers after kainic acid lesion in the adult rat. J Comp Neurol 1998; 396:193–210.

    Article  PubMed  CAS  Google Scholar 

  131. Meixner A, Haverkamp S, Wassle H et al. MAP1B is required for axon guidance and Is involved in the development of the central and peripheral nervous system. J Cell Biol 2000; 151:1169–78.

    Article  PubMed  CAS  Google Scholar 

  132. Togel M, Wiche G, Propst F. Novel features of the light chain of microtubule-associated protein MAP1B: Microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain. J Cell Biol 1998; 143: 695–707.

    Article  PubMed  CAS  Google Scholar 

  133. Pedrotti B, Islam K. Dephosphorylated but not phosphorylated microtubule associated protein MAP1B binds to microfilaments. FEBS Lett 1996; 388:131–3.

    Article  PubMed  CAS  Google Scholar 

  134. Noiges R, Eichinger R, Kutschera W et al. Microtubule-associated protein 1A (MAP1A) and MAP1B: Light chains determine distinct functional properties. J Neurosci 2002; 22:2106–14.

    PubMed  CAS  Google Scholar 

  135. Bolsover, SR. Calcium signalling in growth cone migration. Cell Calcium 2005; 37:395–402.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Université Pierre et Marie Curie, Paris, France

    Céline Bouquet

  2. Fatiha Nothias-UMR7101/IFR83, CNRS-UPMC, Université P&M Curie, Bat. A/3ème Etage, Case-2, 7 Quai Saint Bernard, 75005, Paris, France

    Fatiha Nothias

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  1. Céline Bouquet
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  2. Fatiha Nothias
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Editors and Affiliations

  1. Laboratoire de Neurobiologie du Developpement et de la Regeneration (LNDR), Centre de Neurochimie de CNRS, Strasbourg, France

    Dominique Bagnard Ph.D.

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© 2007 Landes Bioscience and Springer Science+Business Media

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Bouquet, C., Nothias, F. (2007). Molecular Mechanisms of Axonal Growth. In: Bagnard, D. (eds) Axon Growth and Guidance. Advances in Experimental Medicine and Biology, vol 621. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76715-4_1

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