Molecular Mechanisms of Axonal Growth

  • Céline Bouquet
  • Fatiha Nothias
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 621)


Outgrowth of axons during neuronal development, as well as their regeneration after injury, of the adult nervous system is controlled by specific extracellular cues which are diffusible, or bound to cell membranes or extracellular matrix. The exact molecular mechanisms through which these extracellular signals are integrated by the growing axon, are not yet well defined. However, it is widely accepted that most, if not all, signaling cascades triggered by guidance cues eventually converge onto the cytoskeleton. The action of extracellular guidance factors is thus modulated not only by specific membrane receptors, but also by cytoskeletal and cytoskeleton-associated molecules within the axon. In fact, the cytoskeleton represents a point of convergence and integration of both neuron-intrinsic and extrinsic factors. Moreover, in recent years, there has been increasing evidence for the involvement of a coordinated cross-talk between actin filaments and microtubules, the two main components of the growth cone cytoskeleton. Their reorganization is complex and involves numerous cytoskeleton-associated proteins whose function is regulated via activation or inhibition of particular signaling pathways 1, 2, 3, 4.


Actin Filament Growth Cone Axonal Growth Adult Nervous System Neuronal Growth Cone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Céline Bouquet
    • 1
  • Fatiha Nothias
    • 2
  1. 1.Université Pierre et Marie CurieParisFrance
  2. 2.Fatiha Nothias-UMR7101/IFR83, CNRS-UPMCUniversité P&M CurieParisFrance

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