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Quantum Dots for Cancer Molecular Imaging

  • Xiaohu Gao
  • Shivang R. Dave
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 620)

Abstract

Quantum dots (QDs), tiny light-emitting particles on the nanometer scale, are emerging as a new class of fluorescent probes for biomolecular and cellular imaging. In comparison with organic dyes and fluorescent proteins, quantum dots have unique optical and electronic properties such as size-tunable light emission, improved signal brightness, resistance against photobleaching, and simultaneous excitation of multiple fluorescence colors.1 These properties are most promising for improving the sensitivity of molecular imaging and quantitative cellular analysis by 1–2 orders of magnitude. Recent advances have led to multifunctional nanoparticle probes that are highly bright and stable under complex in-vivo conditions. A new structural design involves encapsulating luminescent QDs with amphiphilic block copolymers, and linking the polymer coating to tumor-targeting ligands and drug-delivery functionalities. Polymer-encapsulated QDs are essentially nontoxic to cells and small animals, but their long-term in-vivo toxicity and degradation need more careful studies. Nonetheless, bioconjugated QDs have raised new possibilities for ultrasensitive and multiplexed imaging of molecular targets in living cells and animal models.

Keywords

Sentinel Lymph Node Fluorescence Resonance Energy Transfer Sentinel Lymph Node Mapping Macmillian Publisher Fluorescent Nanocrystals 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Xiaohu Gao
    • 1
  • Shivang R. Dave
    • 1
  1. 1.Department of BioengineeringUniversity of WashingtonSeattleUSA

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