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Toxicity Studies of Fullerenes and Derivatives

  • Jelena Kolosnjaj
  • Henri Szwarc
  • Fathi Moussa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 620)

Abstract

Due to their unique properties, fullerenes, a model of carbon-based nanoparticles, have attracted considerable interest in many fields of research including material science and biomedical applications. The potential and the growing use of fullerenes and their mass production have raised several questions about their safety and environmental impact. Available data clearly shows that pristine C60 has no acute or sub-acute toxicity in a large variety of living organisms, from bacteria and fungal to human leukocytes, and also in drosophila, mice, rats and guinea pigs. In contrast to chemically—either covalently or noncovalently—modified fullerenes, some C60 derivatives can be highly toxic. Furthermore, under light exposure, C60 is an efficient singlet oxygen sensitizer. Therefore, if pristine C60 is absolutely nontoxic under dark conditions, this is not the case under UV-Visible irradiation and in the presence of O2 where fullerene solutions can be highly toxic through 1 O2 formation.

This chapter offers a general review of the studies on the toxicity of [60] fullerence or C60, the most abundant fullerene, and its derivatives.

Keywords

Toxicity Study Subacute Toxicity Virucidal Activity Solvent Exchange Process Bacterial Reverse Mutation Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Jelena Kolosnjaj
    • 1
    • 2
  • Henri Szwarc
    • 1
  • Fathi Moussa
    • 1
  1. 1.UMR CNRS 8612Faculté de PharmacieChâtenay-MalabryFrance
  2. 2.Pharmacy DepartmentUniversity of LjubljanaLjubljanaSlovenia

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