Penetrating Keratoplasty and Glaucoma

  • Michele L. Scott
  • Peter A. Netland


Multiple mechanisms can lead to the development of glaucoma following penetrating keratoplasty (PK), including open and closed angle mechanisms. Previously controlled glaucoma can become uncontrolled or elevated intraocular pressure (IOP) can develop following penetrating keratoplasty. Treatment in these patients can be complex, and the glaucoma is often refractory to medical therapy.


Cystoid Macular Edema Carbonic Anhydrase Inhibitor Graft Survival Rate Corneal Graft Penetrate Keratoplasty 
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  1. 1.
    Ficker LA, Kirkness CM, Steele ADM, et al. Intraocular surgery following penetrating keratoplasty: the risks and advantages. Eye. 1990;4:693–697.PubMedGoogle Scholar
  2. 2.
    Beebe WE. Management of glaucoma in penetrating keratoplasty patients. Refract Corneal Surg. 1991;7:67–69.PubMedGoogle Scholar
  3. 3.
    Al-Mohamimeed M, Al-Shahwan S, Al-Torbak A, Wagoner MD. Escalation of glaucoma therapy after penetrating keratoplasty. Ophthalmology. 2007;114:2281–2286.CrossRefGoogle Scholar
  4. 4.
    Goldberg DB, Schanzlin DJ, Brown SI. Incidence of increased of intraocular pressure after keratoplasty. Am J Ophthalmol. 1981;92:372–377.PubMedGoogle Scholar
  5. 5.
    Kirkness CM, Ficker LA. Risk Factors for the development of postkeratatplasty glaucoma. Cornea. 1992;11:427–432.CrossRefPubMedGoogle Scholar
  6. 6.
    Brandt JD, Lim MC, O’Day DG. Glaucoma after penetrating keratoplasty. In: Krachmer JH, Mannis MJ, Holland EJ, eds. Cornea. 2nd ed. CV Mosby: St. Louis; 2004:1575–1589.Google Scholar
  7. 7.
    Foulks GN, Perry HD, Dohlman CH. Oversize corneal donor grafts in penetrating keratoplasty. Ophthalmology. 1979;86:490–494.PubMedGoogle Scholar
  8. 8.
    Konowal A, Morrison JC, Brown SV, et al. Irreversible corneal decompensation in patients treated with topical dorzolamide. Am J Ophthalmol. 1999;129:403–406.CrossRefGoogle Scholar
  9. 9.
    Wand M, Gilbert CM, Liesegang TJ. Latanoprost and herpes simplex keratitis. Am J Ophthalmol. 2002;133:393–397.CrossRefPubMedGoogle Scholar
  10. 10.
    Ishioka M, Shimazaki J, Yamagami J, Fujishima H, Shimmura S, Tsubota K. Trabeculectomy with mitomycin C for post-keratoplasty glaucoma. Br J Ophthalmol. 2000;84:714–717.CrossRefPubMedGoogle Scholar
  11. 11.
    Kwon YH, Taylor JM, Hong S, et al. Long-term results of eyes with penetrating keratoplasty and glaucoma drainage tube implant. Ophthalmology. 2001;108:272–278.CrossRefPubMedGoogle Scholar
  12. 12.
    Alvarenga LS, Mannis MJ, Brandt JD, Lee WB, Schwab IR, Lim MC. The long-term results of keratoplasty in eyes with a glaucoma drainage device. Am J Ophthalmol. 2004;13:200–205.CrossRefGoogle Scholar
  13. 13.
    Arroyave CP, Scott IU, Fantes FE, Feuer WJ, Murray TG. Corneal graft survival and intraocular pressure control after penetrating keratoplasty and glaucoma drainage device implantation. Ophthalmology. 2001;108:1978–1985.CrossRefPubMedGoogle Scholar
  14. 14.
    Sidoti PA, Mosny AY, Ritterband DC, Seedor JA. Pars plana tube insertion of glaucoma drainage implants and penetrating keratoplasty in patients with coexisting glaucoma and corneal disease. Ophthalmology. 2001;108:1050–1058.CrossRefPubMedGoogle Scholar
  15. 15.
    Cohen EJ, Schwartz LW, Luskind RD, et al. Neodymium:YAG Laser transscleral cyclophotocoagulation for glaucoma after penetrating keratoplasty. Ophthalmic Surg. 1989;20:713–716.PubMedGoogle Scholar
  16. 16.
    Shah P, Lee GA, Kirwan JK, et al. Cyclodiode photocoagula­tion for refractory glaucoma after penetrating keratoplasty. Ophthalmology. 2001;108:1986–1991.CrossRefPubMedGoogle Scholar
  17. 17.
    Ayyala RS, Pieroth L, Vinals AF, et al. Comparison of mitomycin C trabeculectomy, glaucoma drainage device implantation, and laser neodymium:YAG cyclophotocoagulation in the management of intractable glaucoma after penetrating keratoplasty. Ophthalmology. 1998;105:1550–1556.CrossRefPubMedGoogle Scholar
  18. 18.
    Kirkness CM, Steele AD, Ficker LA, Rice NS. Coexistent corneal disease and glaucoma managed by either drainage surgery and subsequent keratoplasty or combined drainage surgery and penetrating keratoplasty. Br J Ophthalmol. 1992;76:146–152.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Michele L. Scott
    • 1
  • Peter A. Netland
    • 2
  1. 1.Hamilton Eye Institute, University of Tennessee Health Science CenterMemphisUSA
  2. 2.Department of OphthalmologyUniversity of Virginia School of MedicineCharlottesvilleUSA

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