Monocular Drug Trials for Glaucoma Therapy in the Community Setting

  • Tony Realini


The clinical management of glaucoma would be far simpler if all patients responded equally well to therapy with IOP-lowering medication. Unfortunately, this is not the case. Consider that timolol offers median IOP reduction of approximately 5-6 mmHg. This does not mean that every patient will manifest a 5-6 mmHg IOP reduction. Rather, it means that half of the patients will enjoy an IOP reduction exceeding this median amount, while the other half will have a lesser IOP reduction. There is currently no way of identifying a priori how patients will respond to their medication; we are limited to a trial and error approach, a so-called n-of-one trial.


Glaucoma Patient Topical Carbonic Anhydrase Inhibitor Bilateral Therapy Monocular Trial Latanoprost Acid 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Tony Realini
    • 1
  1. 1.Department of OphthalmologyWest Virginia UniversityMorgantownUSA

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