Fuchs’ Endothelial Dystrophy and Glaucoma

  • Blair Boehmer
  • Clark Springs


Fuchs’ Endothelial Dystrophy (FED) is a common disorder of the cornea that causes slow progressive endothelial degeneration with subsequent corneal edema and loss of vision in late stages. It is characterized by a thickened Descemet’s membrane (DM) from the aberrant deposition of wide-spaced collagen and the development of guttae, or posterior excrescences that represent projections of abnormal extracellular matrix between DM and endothelial cells. The bilateral, though asymmetric, condition often presents clinically between the fourth and seventh decades of life and is reported to have a female predominance as high as 3.5:1. Pedigree analysis reveals an autosomal dominant inheritance pattern with variable expressivity, although sporadic cases are also reported. While several hypotheses exist, the primary etiology of FED is unknown. Multiple studies have proposed an association between FED and glaucoma including primary open angle, angle closure, and other glaucomas. The relationships remain unclear.


Trabecular Meshwork Angle Closure Anterior Chamber Depth Corneal Endothelium Angle Closure Glaucoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Blair Boehmer
    • 1
  • Clark Springs
    • 2
  1. 1.Department of OphthalmologyIndiana University School of MedicineIndianapolisUSA
  2. 2.Department of OphthalmologyIndiana UniversityIndianapolisUSA

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