Ghost Cell Glaucoma

  • Dinorah P. Engel Castro
  • Cynthia Mattox


Ghost cell glaucoma was first described in 1976 by Campbell and coworkers as a transient secondary open angle glaucoma in which the trabecular meshwork is obstructed by degenerated red blood cells called “ghost cells.” Ghost cells may develop in any remaining red blood cells 7-10 days following vitreous hemorrhage from any etiology. The erythrocytes become spherical, less pliable, and partially lose their intracellular hemoglobin, causing them to appear tan-colored. The denaturized hemoglobin left in the cytoplasm binds to the internal surface of the cell membrane forming granules (Heinz bodies). Ghost cells, once formed, may remain for months in the vitreous cavity after hemorrhage. These vitreous ghost cells can gain access to the anterior chamber through a disrupted anterior hyaloid face, or an open posterior capsule from previous surgery, after traumatic injury or spontaneously. Ghost cells are less pliable than fresh cells; thus, once in the anterior chamber, they may obstruct the trabecular meshwork and markedly increase intraocular pressure.


Diabetic Retinopathy Anterior Chamber Proliferative Diabetic Retinopathy Trabecular Meshwork Vitreous Hemorrhage 


  1. 1.
    Campbell DG, Simmons RJ, Grant WM. Ghost cells as a cause of glaucoma. Am J Ophthalmol. 1976;81:441–450.PubMedGoogle Scholar
  2. 2.
    Campbell DG, Simmons RJ, Tolentino FI, McMeel JW. Glaucoma occurring after closed vitrectomy. Am J Ophthalmol. 1977;83:63–69.PubMedGoogle Scholar
  3. 3.
    Campbell DG. Ghost cell glaucoma following trauma. Ophthalmology. 1981;88:1151–1158.PubMedGoogle Scholar
  4. 4.
    Mansour AM, Chess J, Starita R. Nontraumatic ghost cell glaucoma - a case report. Ophthalmic Surg. 1986;17:34–36.PubMedGoogle Scholar
  5. 5.
    Rojas L, Ortiz G, Gutiérrez M, Corredor S. Ghost cell glaucoma related to snake poisoning. Arch Ophthalmol. 2001;119:1212–1213.PubMedGoogle Scholar
  6. 6.
    Campbell DG, Schertzer R. Ghost cell glaucoma. In: Ritch R, Shields MB, Krupin T, eds. The Glaucomas. 2nd ed. St Louis: Mosby-Year Book; 1996.Google Scholar
  7. 7.
    Cameron JD, Havener VR. Histologic confirmation of ghost cell glaucoma by routine light microscopy. Am J Ophthalmol. 1983; 96:251–252.PubMedGoogle Scholar
  8. 8.
    Summers CG, Lindstrom RL, Cameron JD. Phase contrast microscopy. Diagnosis of ghost cell glaucoma following cataract extraction. Surv Ophthalmol. 1984;28:342–344.Google Scholar
  9. 9.
    Abu el-Asrar AM, al-Obeidan SA. Pars plana vitrectomy in the management of ghost cell glaucoma. Int Ophthalmol. 1995;19:121–124.CrossRefPubMedGoogle Scholar
  10. 10.
    Campbell DG, Essigmann EM. Hemolytic ghost cell glaucoma. Further studies. Arch Ophthalmol. 1979;1997:2141–2146.Google Scholar
  11. 11.
    Summers CG, Lindstrom RL. Ghost cell glaucoma following lens implantation. J Am Intraocul Implant Soc. 1983;9:429–433.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Dinorah P. Engel Castro
    • 1
  • Cynthia Mattox
    • 2
  1. 1.New England Eye Center, Department of Ophthalmology/Glaucoma ServiceTufts Medical CenterBostonUSA
  2. 2.Department of OphthalmologyNew England Eye Center, Tufts University School of MedicineBostonUSA

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