Electrophysiological and Electrochemical Background



In this chapter we present some selected elementary knowledge concerning both the electro-physiology and electro-chemistry of the heart (for details see [1, 2, 3, 4]). This information covers the structures and properties of cardiac cells and tissues, required for understanding the formulation of the mathematical models of action potential (AP) generation and propagation. The basic terminology and definitions are introduced as is required by the discussed topics. Additional physiological information and definitions will be introduced in the following chapters as soon as they become necessary.

The basic distinctive features of cardiac cells and tissues are the properties of excitability and contractility. Excitability is defined as the ability of cardiac cells and tissues to respond to an over-threshold stimulation by generating and propagating electrical pulses – action potentials (APs). Contractility is the ability of cell contractile elements to shorten the cell length in response to an increase in intracellular Ca concentration in the process of developing AP (depolarization phase of membrane potential)


Cardiac Cell Outward Current Thick Filament Purkinje Fiber Intercalate Disc 
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  1. 1.
    Guyton, A.C. and J.E. Hall, Textbook of Medical Physiology. 9th ed. 1996, Philadelphia: W.B. Saunders.Google Scholar
  2. 2.
    Hoffman, B.F. and P.F. Cranefield, Electrophysiology of the Heart. 1960, New York: McGraw- Hill.Google Scholar
  3. 3.
    Keener, J. and J. Sneyd, Mathematical Physiology. 2nd ed. 2001: Springer-Verlag.Google Scholar
  4. 4.
    Zipes, D. and J. Jalife, eds. Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. 1995, W.B. Saunders: Philadelphia.Google Scholar
  5. 5.
    Morozova, O.L., Ultrastructure of heart cells and their junctions. Cardiology (Russian), 1978. 12: 121–131.Google Scholar
  6. 6.
    Bers, D.M., Excitation-Contraction Coupling and Cardiac Contractile Force. 2nd ed. 2001, Norwell, MA: Kluwer Academic Publishers.Google Scholar
  7. 7.
    Langer, G.A., ed. The Myocardium. 2nd ed. 1997, Academic Press: San Diego.Google Scholar
  8. 8.
    Hodgkin, A.L. and A.F. Huxley, A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol, 1952. 117: 500–544.Google Scholar
  9. 9.
    Sakmann, B. and E. Neher, eds. Single Channel Recording. 1983, Plenum Press: New York.Google Scholar
  10. 10.
    Bezanilla, F. and C.M. Armstrong, Inactivation of the sodium channel. I. Sodium channel experiments. J Gen Physiol, 1977. 70: 549–566.CrossRefGoogle Scholar
  11. 11.
    Armstrong, C.M. and F. Bezanilla, Inactivation of the sodium channel. II. Gating current experiments. J Gen Physiol, 1977. 70: 567–590.CrossRefGoogle Scholar
  12. 12.
    Noble, D., A modification of the Hodgkin-Huxley equations applicable to Purkinje fiber action and pace-maker potentials. J Physiol, 1962. 160: 317–352.Google Scholar
  13. 13.
    Luo, C.H. and Y. Rudy, A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ Res, 1994. 74: 1071–1096.Google Scholar
  14. 14.
    Zeng, J., K.R. Laurita, D.S. Rosenbaum, and Y. Rudy, Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circ Res, 1995. 77: 140–152.Google Scholar
  15. 15.
    Antzelevitch, C., S. Sicouri, and A. Lukas, Clinical implications of electrical heterogeneity in the heart: The electrophysiology and pharmacology of epicardial, M and endocardial cells., in Cardiac Arrhythmia: Mechanism, Diagnosis and Management, P.J. Podrid and P.R. Kowey, Editors. 1995, William & Wilkins: Baltimore, MD. p. 88–107.Google Scholar

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Computer ScienceUniversity of California, Los AngelesLos AngelesUSA

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