Drug Addiction pp 617-624 | Cite as

Mu Opioid Receptor Regulation and Opiate Responsiveness


Opiate drugs such as morphine are well known for their ability to produce potent analgesia as well as such unwanted side effects as tolerance, physical dependence, respiratory suppression and constipation. Opiates act at opioid receptors, which belong to the family of G protein-coupled receptors. The mechanisms governing mu opioid receptor (μOR) regulation are of particular interest since morphine and other clinically important analgesics produce their pharmacological effects through this receptor. Here we review recent advances in understanding how opioid receptor regulation can impart differential agonist efficacy produced in vivo.


Opioid Receptor Locus Coeruleus Chronic Morphine GPCR Signaling Receptor Endocytosis 


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Copyright information

© American Association of Pharmaceutical Scientists 2008

Authors and Affiliations

  1. 1.Departments of Pharmacology & PsychiatryThe Ohio State University College of Medicine and Public HealthColumbus

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