Inflammatory Patterns and Lymphoma

  • William C. Faquin
  • Celeste N. Powers
Part of the Essentials in Cytopathology Series book series (EICP, volume 5)

Inflammation of the salivary glands can take several different forms: acute or chronic sialadenitis, lymphoepithelial lesions, or granulomatous disease. Acute sialadenitis is usually a bacterial inflammation of the salivary glands that most commonly affects the parotid gland. The serous nature of the parotid gland saliva, which is less antimicrobial than mucinous saliva, makes it more susceptible to this process. Acute sialadenitis tends to occur more often in individuals who are older and/or medically debilitated, and it is especially common as a postoperative complication. Other causes of acute sialadenitis include stenosis of the salivary duct system due to trauma or sialolithiasis. Importantly, neoplastic conditions can also lead to duct obstruction with accompanying acute and/or chronic sialadenitis. In contrast to older adults, children with acute sialadenitis are affected by the less clinically aggressive nonsuppurative acute parotitis secondary to infection with paramyxovirus (mumps). Most cases of acute sialadenitis in adults result from oral bacterial infection of the salivary ducts. The bacterial causes of acute sialadenitis include Staphylococcus aureus, Streptococcus spp., and Haemophilus influenzae. Patients with acute sialadenitis present with acute onset of pain, swelling, fever, and chills and are managed aggressively, which includes antimicrobial therapy as a cornerstone of the treatment. Untreated suppurative parotitis can be associated with several severe medical complications and even death.


Salivary Gland Malt Lymphoma Mucoepidermoid Carcinoma Lymphoepithelial Lesion Warthin Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Allen EA, Ali AZ, Mathew S. Lymphoid lesions of the parotid. Diagn Cytopathol 1999;21:170–173.PubMedCrossRefGoogle Scholar
  2. Chan ACL, Chan JKC, Abbondanzo SL. Haematolymphoid tumors. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds). World Health Organization Classification of Tumours: Head and Neck Tumours. Lyon: IARC Press, 2005: 277–280.Google Scholar
  3. Chhieng DC, Cangiarella JF, Cohen J-M. Fine-needle aspiration cytology of lymphoproliferative lesions involving the major salivary glands. Am J Clin Pathol 2000;113:563–571.PubMedCrossRefGoogle Scholar
  4. Droese M. Cytological diagnosis of sialadenosis, sialadenitis, and parotid cysts by fine-needle aspiration biopsy. Adv Otorhinolaryngol 1981;26:49–96.PubMedGoogle Scholar
  5. Jaffe ES, Harris NL, Stein H, Vardiman JW (eds). World Health Organization Classification of Tumours: Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2001.Google Scholar
  6. Pantanowitz L, Goulart R, Cao JQ. Salivary gland crystalloids. Diagn Cytopathol 2006 ;34 :749–750.PubMedCrossRefGoogle Scholar
  7. Quintana PG, Kapadia SB, Bahler DW, Johnson JT, Swerdlow SH. Salivary gland lymphoid infiltrates associated with lymphoepithelial lesions: a clinicopathologic, immunophenotypic, and genotypic study. Hum Pathol 1997;21:850–861.CrossRefGoogle Scholar
  8. Remstein ED, Dogan A, Einerson RR, Paternoster SF, Fink SR, Law M, Dewald GW, Kurtin PJ. The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America. Am J Surg Pathol 2006;30:1546–1553.PubMedCrossRefGoogle Scholar
  9. Rice DH. Chronic inflammatory disorders of the salivary glands. Otolaryngol Clin North Am 1999;32:813–834.PubMedCrossRefGoogle Scholar
  10. Rice DH. Non-neoplastic disorders of the salivary glands. Otolaryngol Clin North Am 1999;32:835–843.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • William C. Faquin
    • 1
  • Celeste N. Powers
    • 2
  1. 1.Department of Pathology, Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  2. 2.Department of Pathology, Medical College of Virginia HospitalsVirginia Commonwealth UniversityRichmondUSA

Personalised recommendations