General Principles of Drug Treatment of Hyperlipidemia
Be sure the intensity of therapy is guided by an accurate coronary risk assessment of the patient.
Maximize monotherapy before starting combination drug therapy.
Prescribe a dosage of a statin designed to reach your target LDL level as your initial dose as opposed to dosage titration.
Select medicines appropriate for any patient comorbidity.
Individualize your therapeutic plan for each patient by remaining cognizant of unique issues that special populations may present (see Chapter 7).
Each of these five key principles is now be reviewed in detail.
Base Intensity of Drug Therapy on an Accurate Risk Assessment
Intensity of therapy should be guided by...
KeywordsHigh Density Lipoprotein Irritable Bowel Syndrome Grapefruit Juice Creatinine Kinase Bile Acid Sequestrant
- 1.Choice of lipid regulating drugs. Med Lett 2001;43:43–48.Google Scholar
- 2.Three new drugs for hyperlipidemia. Med Lett 2003;45:17–19.Google Scholar
- 7.Lemos JA, Blazing MA, Wiviott SD, et al. Early intensive vs. a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial. N Engl J Med 2004;292:1307–1316.Google Scholar
- 9.Anonymous. Efficacy and safety of cholesterol lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomized trials of statins. Lancet 2005;366: 1267–1277.Google Scholar
- 10.Fish oil supplements. Med Lett 2006;48:59–60.Google Scholar
- 12.Vytorin. Med Lett 2004;46:73–74.Google Scholar
- 13.Kweiterovich PO. Review of lipid modifying drugs used alone or in combination. Adv Stud Med 2005;5:475–491.Google Scholar
- 19.CTT Collaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90056 participants in 14 randomised trials of statins. Lancet. 2005;366:1267–1278.Google Scholar
- 24.MICROMEDEX (2006). DRUGDEX Evaluations: Ezetimibe.Google Scholar
- 29.Rader DJ. Regulation of reverse cholesterol transport and clinical implications. Am J Cardiol 2003;92(4A):42 J–49 J.Google Scholar