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PET in the Evaluation of Alzheimer's Disease and Related Disorders pp 67–92Cite as

PET and SPECT in the Evaluation of Patients with Central Motor Disorders

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In the nearly 200 years since the first modern clinical description of the spectrum of bradykinesia, tremor, and gait disturbance by James Parkinson, tremendous progress has been made in the understanding and clinical management of movement disorders. 1 In particular, the discovery of the pathologic changes occurring in the brain in patients with these disorders directly led to the development of effective symptomatic treatments and set the current focus on the next generation of therapeutics designed to interrupt the progression of disease. Neuroimaging methods, especially positron emission tomography (PET) and single photon emission tomography (SPECT), have now assumed an important role in the refinement in understanding of differential diagnosis and clinical course by providing disease-relevant biomarkers that complement other clinical measures. Nonetheless, as scintigraphic methods are still early in the routine application to the diagnosis and management of Parkinson’s disease (PD) and related disorders, intense interest and some controversy remains as to their ultimate clinical application

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  1. Imaging Division, Institute for Neurodegenerative Disorders, New Haven, CT

    John P. Seibyl (Senior Scientist)

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    Seibyl, J.P. (2009). PET and SPECT in the Evaluation of Patients with Central Motor Disorders. In: Silverman, D. (eds) PET in the Evaluation of Alzheimer's Disease and Related Disorders. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76420-7_4

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