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Baboon Models for Neonatal Lung Disease

  • Bradley A. Yoder
  • Donald C. McCurnin
  • Jacqueline J. Coalson
Part of the Developments in Primatology: Progress and Prospects book series (DIPR)

Over 4,000,000 children are born in the United States annually. The most recent national statistics (Arias et al., 2003) report that the premature birth rate (gestation <37 completed weeks) has increased to 12.0%. The birth rate for premature infants at the highest risk for complications, those born ≤28 weeks gestation, is approximately 1% or 40,000 births per year. Over the past two decades, advances in prenatal and neonatal intensive care have contributed to marked improvements in survival rates for these extremely immature infants (Gould et al., 2000; Berger et al., 2004). The average hospital cost per survivor, however, has increased from approximately $12,000 in 1979 (Shannon et al., 1981) to over $125,000 in 1996 (Gilbert et al., 2003). The total estimated annual cost to treat these extremely high-risk patients exceeds one billion dollars (St. John et al., 2000). Many of the surviving infants have residual chronic illness, including bronchopulmonary dysplasia (BPD) and cerebral palsy, which further contribute to increased health care costs following hospital discharge (Ireys et al., 1997). In light of the staggering medical, social, familial, and economic costs imposed by such infants, significant research dollars continue to be spent to better define the mechanisms of premature birth, to understand the developmental biology of the very immature infant, and to identify therapeutic interventions for improving outcomes.

Keywords

Patent Ductus Arteriosus Lung Development Hyaline Membrane Disease Antenatal Steroid Surfactant Replacement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Bradley A. Yoder
    • 1
    • 3
  • Donald C. McCurnin
    • 2
    • 3
  • Jacqueline J. Coalson
    • 1
    • 3
  1. 1.Departments of PathologyUniversity of Texas Health Science Center at San AntonioSan Antonio
  2. 2.Departments of PediatricsUniversity of Texas Health Science Center at San AntonioSan Antonio
  3. 3.Department of Physiology and MedicineSouthwest Foundation for Biomedical ResearchSan Antonio

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