The Baboon in Embryology and Teratology Research

  • Andrew G. Hendrickx
  • Pamela E. Peterson
Part of the Developments in Primatology: Progress and Prospects book series (DIPR)

Studies of embryonic development in the red baboon (Papio hamadryas papio) were first reviewed by Hill (1932). Subsequent studies were carried out by Gilbert and Heuser (1954), Schuster (1965), and Boyden (1967) in P. h. ursinus, P. h. anubis, P. h. cynocephalus, and P. h. anubis, respectively. Zuckerman (1963) has provided an excellent history of nonhuman primates in biomedical history for the first half of the 20th century. His account credits Galen of Pergamum who based the descriptions of human anatomy on baboons and other primates.


Cynomolgus Monkey Nasal Septum Triamcinolone Acetonide Rubella Virus Cynomolgus Macaque 
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  1. Bielert, C., Bernstein, R., Simon, G. B., and van der Walt, L. A. (1980). XY gonadal dysgenesis in a chacma baboon (Papio ursinus). Int. J. Primatol. 1:3–13.CrossRefGoogle Scholar
  2. Boyden, E. A. (1967). The choledochoduodenal junction in the Kenya Baboon (Papio cynocephalus and Papio anubis). In: Vagtborg, H. (ed.), The Baboon in Medical Research, Vol. 2. University of Texas Press, Austin, pp. 117–132.Google Scholar
  3. Brent, R. R. (1983). The Bendectin Saga: Another American tragedy. Teratolology 27:283–286.CrossRefGoogle Scholar
  4. Brent, R. L. (1995). Bendectin: Review of the medical literature of a comprehensively studied human nonteratogen and the most prevalent tortogen-litigen. Reprod. Toxicol. 9:337–349.CrossRefPubMedGoogle Scholar
  5. Buss, D. H., and Hamner, J. E., III. (1971). Supernumerary nipples in the baboon (Papio cynocephalus). Folia Primatol. 16:153–158.CrossRefPubMedGoogle Scholar
  6. Cameron, A. H., and Hill, W. C. O. (1955). The Arnold-Chiari malformation in a sacred baboon (Papio hamadryas). J. Pathol. Bacteriol. 70:552–554.CrossRefPubMedGoogle Scholar
  7. Cordero, J. F., and Oakley, G. P., Jr. (1983). Drug exposure during pregnancy: Some epidemiologic considerations. Clin. Obstet. Gynecol. 26:418–428.CrossRefPubMedGoogle Scholar
  8. Delahunt, C. S. (1966). Rubella-induced cataracts in monkeys. Lancet 287:825.CrossRefGoogle Scholar
  9. Gilbert, C., and Heuser, C. H. (1954). Studies in the development of the baboon embryo (Papio ursinus): A description of two presomite and two late somatic stage embryos. Contrib. Embryol. Carneg. Inst. 35:13–54.Google Scholar
  10. Gregg, N. M. (1941). Congenital cataract following German measles in the mother. Trans. Ophthalmol. Soc. Aust. 3:35–46.Google Scholar
  11. Gribnau, A. A. M., and Geijsberts, L. G. M. (1981). Developmental stages in the rhesus monkey (Macaca mulatta). Adv. Anat. Embryol. Cell Biol. 68:1–84.PubMedGoogle Scholar
  12. Gribnau, A. A. M., and Geijsberts, L. G. M. (1985). Morphogenesis of the brain in staged rhesus monkey embryos. Adv. Anat. Embryol. Cell Biol. 91:1–69.PubMedGoogle Scholar
  13. Henck, J. W., Hilbish, K. G., Serabian, M. A., Cavagnara, J. A., Hendrickx, A. G., Agnish, N. D., Kung, A. H. C., and Mordenti, J. (1996). Reproductive toxicity testing of therapeutic biotechnology agents. Teratology 53:185–195.CrossRefPubMedGoogle Scholar
  14. Hendrickx, A. G. (1966). Teratogenicity findings in a baboon colony. In: Miller, C. O. (ed.), Proceedings – Conference on Nonhuman Primate Toxicology. Department of Health, Education, and Welfare, Food and Drug Administration, Washington, DC, pp. 120–123.Google Scholar
  15. Hendrickx, A. G. (1971a). Embryology of the Baboon. The University of Chicago Press, Chicago, p. 212.Google Scholar
  16. Hendrickx, A. G. (1971b). Teratogenicity of thalidomide in the baboon (Papio cynocephalus), bonnet monkey (Macaca radiata) and cynomolgus monkey (Macaca irsu). In: Biegert, J. and Leutenegger, W. (eds.), Proceedings of the Third International Congress on Primatology, Vol. 2. Neurobiology, Immunology, Cytology. S. Karger, Basel, pp. 230–237.Google Scholar
  17. Hendrickx, A. G., and Binkerd, P. E. (1980). Fetal deaths in nonhuman primates. In: Porter, I. H. and Hook E. B. (eds.), Human Embryonic and Fetal Death. Academic Press, New York, pp. 45–69.Google Scholar
  18. Hendrickx, A. G., and Binkerd, P. E. (1990). Nonhuman primates and teratological research. J. Med. Primatol. 19:81–108.PubMedGoogle Scholar
  19. Hendrickx, A. G., and Cukierski, M. A. (1987). Reproductive and developmental toxicology in nonhuman primates. In: Graham, C. R. (ed.), Preclinical Safety of Biotechnology Products Intended for Human Use. Alan R. Liss, New York, pp. 73–88.Google Scholar
  20. Hendrickx, A. G., and Gasser, R. F. (1967). A description of a diaphragmatic hernia in a sixteen week baboon fetus (Papio sp.). Folia Primatol. 7:66–74.CrossRefPubMedGoogle Scholar
  21. Hendrickx, A. G., and Katzberg, A. A. (1967). A single umbilical artery in the baboon. Folia Primatol. 5:295–304.CrossRefGoogle Scholar
  22. Hendrickx, A. G., and Peterson, P. E. (1997). Perspectives on the use of the baboon in embryology and teratology research. Hum. Reprod. Update 3:575–592.CrossRefPubMedGoogle Scholar
  23. Hendrickx, A. G., and Prahalada, S. (1986). Teratology and embryogenesis. In: Dukelow, W. R. and Erwin, J. (eds.), Comparative Primate Biology, Vol.. 3: Reproduction and Development. Alan R. Liss, Inc., New York, pp. 333–362.Google Scholar
  24. Hendrickx, A. G., and Sawyer, R. H. (1975). Embryology of the rhesus monkey. In: Bourne, G. H. (ed.), The Rhesus Monkey, Vol. 2. Academic Press, New York, pp. 141–169.Google Scholar
  25. Hendrickx, A. G., and Tarara, R. P. (1990). Animal model of human disease: Triamcinolone acetonide-induced meningocele and meningoencephalocele in rhesus monkeys. Am. J. Pathol. 136:725–727.PubMedGoogle Scholar
  26. Hendrickx, A. G., Axelrod, L. R., and Clayborn, L. D. (1966). Thalidomide syndrome in baboons. Nature 210:958–959.CrossRefPubMedGoogle Scholar
  27. Hendrickx, A. G., Sawyer, R. H., Terrell, T. G., Osburn, B. I., Henrickson, R. V., and Steffek, A. J. (1975). Teratogenic effects of triamcinolone on the skeletal and lymphoid systems in nonhuman primates. Fed. Proc. 34:1661–1665.Google Scholar
  28. Hendrickx, A. G., Pellegrini, M., Tarara, R., Parker, R., Silverman, S., and Steffek, A. J. (1980). Craniofacial and central nervous system malformations induced by triamcinolone acetonide in nonhuman primates: I. General teratogenicity. Teratology 22:103–114.CrossRefPubMedGoogle Scholar
  29. Hendrickx, A. G., Binkerd, P., and Rowland, J. (1983). Developmental toxicity and nonhuman primates: Interspecies comparisons. In: Kalter, H. (ed.), Issues and Reviews in Teratology, Vol. 1. Plenum Press, New York, pp. 149–180.Google Scholar
  30. Hendrickx, A. G., Cukierski, M., Prahalada, S., Janos, G., and Rowland, J. (1985a). Evaluation of bendectin embryotoxicity in nonhuman primates: I. Ventricular septal defects in prenatal macaques and baboon. Teratology 32:179–189.Google Scholar
  31. Hendrickx, A. G., Cukierski, M., Prahalada, S., Janos, G., Booher, S., and Nyland, T. (1985b). Evaluation of bendectin embryotoxicity in nonhuman primates: II. Double-blind study in term cynomolgus monkeys. Teratology 32:191–194.Google Scholar
  32. Hendrickx, A. G., Korte, R., Leuschner, F., Neumann, B. W., Prahalada, S., Poggel, A., Binkerd, P. E., and Günzel, P. (1987). Embryotoxicity of sex steroidal hormone combinations in nonhuman primates: I. Norethisterone acetate + ethinylestradiol and progesterone + estradiol benzoate (Macaca mulatta, Macaca fascicularis, and Papio cynocephalus). Teratology 35: 119–127.CrossRefPubMedGoogle Scholar
  33. Hendrickx, A. G., Tzimas, G., Korte, R., and Hummler, H. (1998). Retinoid teratogenicity in the macaque: Verification of dosing regimen. J. Med. Primatol. 27:310–318.PubMedGoogle Scholar
  34. Hendrickx, A. G., Makori, N., and Peterson, P. (2000a). Nonhuman primates: Their role in assessing developmental effects of immunomodulatory agents. Human Exp. Toxicol. 19:219–225.Google Scholar
  35. Hendrickx, A. G., Peterson, P., Hartmann, D., and Hummler, H. (2000b). Vitamin A teratogenicity and risk assessment in the macaque retinoid model. Reprod. Toxicol. 14:311–323.Google Scholar
  36. Hendrickx, A. G., Makori, N., and Peterson, P. (2002). The non-human primate as a model of developmental immunotoxicity. Hum. Exp. Toxicol. 211:537–542.CrossRefGoogle Scholar
  37. Hendrie, T. A., Peterson, P. E., Short, J. J., Tarantal, A. F., Rothgarn, E., Hendrie, M. I., and Hendrickx, A. G. (1996). Frequency of prenatal loss in a macaque breeding colony. Am. J. Primatol. 40:41–53.CrossRefGoogle Scholar
  38. Hesse, V. E. (1969). Retrocaval ureter. S. Afr. Med. J. 43:561–564.PubMedGoogle Scholar
  39. Hill, J. P. (1932). The developmental history of the primates. Phil. Trans. Roy. Soc. Lond. B Biol. Sci. 221:45–178.CrossRefGoogle Scholar
  40. Katz, Z., Lancet, M., Skornik, J., Chemke, J., Mogilner, B. M., and Klinberg, M. (1985). Teratogenicity of progestogens given during the first trimester of pregnancy. Obstet. Gynecol. 65:775–780.PubMedGoogle Scholar
  41. Kim, C. S., and Kalter, S. S. (1972). Unilateral renal aplasia in an African baboon (Papio sp.). Folia Primatol. (Basel) 17:157–159.CrossRefGoogle Scholar
  42. Kovacs, M. S., Hoganson, G. E., Jr., Hauselman, E. D., Batanian, J. R., and Bennett, B. T. (1992). Roberts-SC phocomelia syndrome in a baboon (Papio anubis). Lab. Anim. Sci. 42:522–525.PubMedGoogle Scholar
  43. Krilova, R. I., and Yakovleva, L. A. (1972). The pattern and abnormality rate of monkeys of the Sukhumi colony. Acta Endocrinol. 71(Suppl. 166):309–321.Google Scholar
  44. Lapin, B. A., and Yakovleva, L. A. (1963). Comparative Pathology in Monkeys. Translated by U.S. Joint Publ. Res. Service. Charles C. Thomas, Springfield, Illinois.Google Scholar
  45. Lenz, W. (1961). Kindliche Missbildungen nach Medikament-einnahme wahrend der Graviditat? Dtsch. Med. Wochenschr. 86:2555–2556.Google Scholar
  46. Makori, N., Rodriguez, C. G., Cukierski, M. A., and Hendrickx, A. G. (1996). Development of the brain in staged embryos of the long-tailed monkey (Macaca fascicularis). Primates 37: 351–361.CrossRefGoogle Scholar
  47. McBride, W. G. (1961). Thalidomide and congenital abnormalities. Lancet2:1358.CrossRefGoogle Scholar
  48. McCraw, A. P., Rotheram, K., Sim, A. K., and Warwick, M. H. (1973). Unilateral renal aplasia in the baboon. J. Med. Primatol. 2:249–251.PubMedGoogle Scholar
  49. Moore, C. M., McKeand, J., Witte, S. M., Hubbard, G. B., Rogers, J., and Leland, M. M. (1998). Teratoma with trisomy 16 in a baboon (Papio hamadryas). Am. J. Primatol. 46:323–332.CrossRefPubMedGoogle Scholar
  50. O’Rahilly, R., and Müller, F. (1987). Developmental Stages in Human Embryos: Including a Revision of Streeter’s “Horizons” and a Survey of the Carnegie Collection. Carnegie Institution of Washington, Washington, DC, Pub. 637, p. 306.Google Scholar
  51. O’Rahilly, R., and Müller, F. (1994). The Embryonic Human Brain: An Atlas of Developmental Stages. Wiley-Liss, New York, p. 342.Google Scholar
  52. Peterson, P. E., Short, J. J., Tarara, R., Valverde, C., Rothgarn, E., and Hendrickx, A. G. (1997). Frequency of spontaneous congenital defects in rhesus and cynomolgus macaques. J. Med. Primatol. 26:267–275.PubMedGoogle Scholar
  53. Prahalada, S., Carroad, E., and Hendrickx, A. G. (1985a). Embryotoxicity and maternal serum concentrations of medroxyprogesterone acetate (MPA) in baboons (Papio cynocephalus). Contraception 32:497–515.Google Scholar
  54. Prahalada, S., Carroad, E., Cukierski, M., and Hendrickx, A. G. (1985b). Embryotoxicity of a single dose of medroxyprogesterone acetate (MPA) and maternal serum MPA concentrations in cynomolgus monkey (Macaca fascicularis). Teratolology 32:421–432.Google Scholar
  55. Pruzansky, S. (1975). Anomalies of face and brain. Birth Defects 11:183–204.PubMedGoogle Scholar
  56. Rowland, J. M., and Hendrickx, A. G. (1983). Corticosteroid teratogenicity. Adv. Vet. Sci. Comp. Med.27:99–128.PubMedGoogle Scholar
  57. Schardein, J. L. (1980). Congenital abnormalities and hormones during pregnancy: A clinical review. Teratology 22:251–270.CrossRefPubMedGoogle Scholar
  58. Schmidt, R. E. (1971). Colobomas in non-human primates. Folia Primatol. 14:256–268.CrossRefPubMedGoogle Scholar
  59. Schuster, G. (1965). Untersuchungen an einem embryo von Papio doguera Pucheran 7-Somiten-Stadium. Anat. Anz. 117:447–475.PubMedGoogle Scholar
  60. Shepard, T. H. (1986). Human teratogenicity. Adv. Pediatr. 33:225–268.PubMedGoogle Scholar
  61. Tarara, R. (1984). The effect of medroxyprogesterone acetate (Depo-Provera) on prenatal development in the baboon (Papio anubis): A preliminary study. Teratology 30:180–185.CrossRefGoogle Scholar
  62. Trown, P. W., Wills, R. J., and Kamm, J. J. (1986). The preclinical development of Roferon®-A. Cancer 57:1648–1656.CrossRefPubMedGoogle Scholar
  63. Wadsworth, P. F., Allen, D. G., and Prentice, D. E. (1978). Pseudohermaphroditism in a baboon (Papio anubis). Toxicol. Lett. 1:261–266.CrossRefGoogle Scholar
  64. Wilkins, L. (1960). Masculinization of female fetus due to use of orally given progestins. J. Am. Med. Assoc. 172:1028–1032.PubMedGoogle Scholar
  65. Wilkins, L., Jones, H. W., Jr., Holman, G. H., and Stempfel, R. S., Jr. (1958). Masculinization of the female fetus associated with administration of oral and intramuscular progestins during gestation: Non-adrenal female pseudohermaphrodism. J. Clin. Endocrinol. Metab. 18: 559–585.CrossRefPubMedGoogle Scholar
  66. Wilson, J. G. (1973). Principles of teratology. Environment and Birth Defects. Academic Press, New York, pp. 11–34.Google Scholar
  67. Wilson, J. G., and Brent, R. L. (1981). Are female sex hormones teratogenic? Am. J. Obstet. Gynecol. 141:567–580.PubMedGoogle Scholar
  68. Wilson, J. G., and Gavan, J. A. (1967). Congenital malformations in nonhuman primates: Spontaneous and experimentally induced. Anat. Rec. 158:99–109.CrossRefPubMedGoogle Scholar
  69. Wilson, J. G., Kalter, H., Palmer, A. K., Hoar, R. M., Shenefelt, R. E., Beck, F., Earl, F. L., Nelson, N. S., Berman, E., Stara, J. F., Selby, L. A., and Scott, W. J., Jr. (1978). Developmental abnormalities. In: Benirschke, K., Garner, F. M., and Jones, T. C. (eds.), Pathology of Laboratory Animals, Vol. II. Springer-Verlag, New York, pp. 1817–1946.Google Scholar
  70. Wiseman, R. A., and Dodds-Smith, I. C. (1984). Cardiovascular birth defects and antenatal exposure to female sex hormones: A reevaluation of some base data. Teratology 30:359–370.CrossRefPubMedGoogle Scholar
  71. Zuckerman, S. (1963). Laboratory monkeys and apes from Galen onwards. In: Pickering, D. E. (ed.), Research with Primates. Tektronix Foundation, Beaverton, Oregon, pp. 1–11.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Andrew G. Hendrickx
    • 1
  • Pamela E. Peterson
    • 1
  1. 1.Center for Health and the Environment, University of California, One Shields AvenueDavis

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