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The Baboon Model of Epilepsy: Current Applications in Biomedical Research

  • C. Ákos Szabó
  • M. Michelle Leland
  • Koyle D. Knape
  • Jeff T. Williams
Part of the Developments in Primatology: Progress and Prospects book series (DIPR)

Epilepsy is a condition of recurrent, unprovoked seizures (Adams and Victor, 1993). Seizures are episodic changes in behavior associated with a synchronized electrical discharge from the populations of neurons in the cerebral cortex. To classify human epilepsies as focal or generalized, clinicians rely on a seizure description combined with electroencephalography (EEG) (Commission on the Classification and Terminology of the International League Against Epilepsy, 1981 and 1989). Because seizures are rarely recorded in brief EEG samples, clinicians rely on the the detection of interictal (between seizures) epileptic discharges, which serve as markers for the seizure type. Focal epilepsies begin with focal symptomatology and are associated with interictal epileptic discharges (IEDs) that are focal or lateralized to one cerebral hemisphere. Generalized epilepsies are associated with sudden unresponsiveness or bilateral motor symptoms at onset, and IEDs tend to involve both hemispheres simultaneously. While most focal epilepsies are symptomatic, related to a localized structural lesion, generalized epilepsies are predominantly idiopathic, and considered to be heritable.

Keywords

Generalize Epilepsy Juvenile Myoclonic Epilepsy Myoclonic Seizure Spontaneous Seizure Ictal Discharge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • C. Ákos Szabó
    • 1
  • M. Michelle Leland
    • 2
  • Koyle D. Knape
    • 1
  • Jeff T. Williams
    • 3
  1. 1.South Texas Comprehensive Epilepsy CenterUniversity of Texas Health Science CenterSan Antonio
  2. 2.Laboratory Animal ResourcesUniversity of Texas Health Science CenterSan Antonio
  3. 3.Department of Genetics and Southwest National Primate Research CenterSouthwest Foundation for Biomedical ResearchSan Antonio

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