There is a vast literature from research with rodents and ungulates on discovery and detailed definition of brain mechanisms and areas that may be involved in the regulation of food, water, and salt intakes, as well as specific appetites for certain minerals, vitamins, and other nutrients. These nonprimate models have led to speculations on the regulatory mechanisms in humans. Some of these speculations and ensuing hypotheses have been examined by non-invasive and opportunistic studies in human subjects. These include disorders of ingestion and appetites arising in a variety of clinical and subclinical situations such as stress, anorexias, obesity, high blood pressure, pregnancy, and aging. However, many experimental designs required to test these hypotheses are not practical with human subjects, and fundamental differences in mechanisms that regulate ingestive behaviors may exist between primates and other mammals. Therefore, our group has established a nonhuman primate model for research on such mechanisms.
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Blair-West, J.R., Denton, D.A., Shade, R.E., Weisinger, R.S. (2009). Baboon Model for Ingestive Behaviors. In: VandeBerg, J.L., Williams-Blangero, S., Tardif, S.D. (eds) The Baboon in Biomedical Research. Developments in Primatology: Progress and Prospects. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75991-3_14
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