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Calcium Dynamics

  • James Keener
  • James Sneyd
Part of the Interdisciplinary Applied Mathematics book series (IAM, volume 8/1)

Calcium is critically important for a vast array of cellular functions, as can be seen by a quick look through any physiology book. For example, in this book we discuss the role that Ca2+ plays in muscle mechanics, cardiac electrophysiology, bursting oscillations and secretion, hair cells, and adaptationin photoreceptors, among other things. Clearly, the mechanisms by which a cell controls its Ca2+ concentration are of central interest in cell physiology.

There are a number of Ca2+ control mechanisms operating on different levels, all designed to ensure that Ca2+ is present in sufficient quantity to perform its neces sary functions, but not in too great a quantity in the wrong places. Prolonged high cytoplasmic concentrations of Ca2+ are toxic. For example, cellular Ca2+ overload can trigger apoptotic cell death, a process in which the cell kills itself. In muscle cells, high intracellular Ca2+ is responsible for prolonged muscle tension and rigor mortis.

Keywords

Bifurcation Diagram Homoclinic Orbit Release Site Ryanodine Receptor Spiral Wave 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • James Keener
    • 1
  • James Sneyd
    • 2
  1. 1.Department of MathematicsUniversity of UtahSalt Lake CityUSA
  2. 2.Department of MathematicsUniversity of AucklandAucklandNew Zealand

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