Calcium Dynamics

  • James Keener
  • James Sneyd
Part of the Interdisciplinary Applied Mathematics book series (IAM, volume 8/1)

Calcium is critically important for a vast array of cellular functions, as can be seen by a quick look through any physiology book. For example, in this book we discuss the role that Ca2+ plays in muscle mechanics, cardiac electrophysiology, bursting oscillations and secretion, hair cells, and adaptationin photoreceptors, among other things. Clearly, the mechanisms by which a cell controls its Ca2+ concentration are of central interest in cell physiology.

There are a number of Ca2+ control mechanisms operating on different levels, all designed to ensure that Ca2+ is present in sufficient quantity to perform its neces sary functions, but not in too great a quantity in the wrong places. Prolonged high cytoplasmic concentrations of Ca2+ are toxic. For example, cellular Ca2+ overload can trigger apoptotic cell death, a process in which the cell kills itself. In muscle cells, high intracellular Ca2+ is responsible for prolonged muscle tension and rigor mortis.


Bifurcation Diagram Homoclinic Orbit Release Site Ryanodine Receptor Spiral Wave 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • James Keener
    • 1
  • James Sneyd
    • 2
  1. 1.Department of MathematicsUniversity of UtahSalt Lake CityUSA
  2. 2.Department of MathematicsUniversity of AucklandAucklandNew Zealand

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