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Heparin-Induced Thrombocytopenia

  • Chapter
Immunogenicity of Biopharmaceuticals

Part of the book series: Biotechnology: Pharmaceutical Aspects ((PHARMASP,volume VIII))

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Abstract

Heparin-induced thrombocytopenia (HIT) is a devastating complication of either unfractionated heparin or any of the low molecular weight heparin (LMWH) preparations. This immune-mediated process generally develops within 5–14 days of administration, although it may occur more rapidly if there has been a recent exposure, or even days to weeks after either preparation has been discontinued. Although once considered necessary for the diagnosis of HIT, thrombocytopenia is no longer essential. A 50 reduction in the platelet count from pre-heparin treatment levels is now considered a more specific finding. Immediate cessation of heparin or LMWH is recommended once the diagnosis is suspected and alternative therapy with a non-heparin anticoagulant advised due to the potential for new thrombosis, amputation or even death.

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Authors
  1. Carmel A. Celestin
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  2. John R. Bartholomew
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  1. University of Copenhagen, Copenhagen, Denmark

    Marco van de Weert

  2. University of Copenhagen, Copenhagen, Denmark

    Eva Horn Møller

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Celestin, C.A., Bartholomew, J.R. (2008). Heparin-Induced Thrombocytopenia. In: Weert, M.v., Møller, E.H. (eds) Immunogenicity of Biopharmaceuticals. Biotechnology: Pharmaceutical Aspects, vol VIII. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75841-1_12

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