Advertisement

Taurine 7 pp 75-84 | Cite as

Antihypertensive Effect of Taurine in Rat

  • Jianmin Hu
  • Xingli Xu
  • Jiancheng Yang
  • Gaofeng Wu
  • Changmian Sun
  • Qiufeng Lv
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)

Abstract

To investigate the effect of taurine on hypertension, a rat model of hypertension was produced by administering N-nitro-L-arginine methylester (L-NAME) to reduce the levels of the vasodilator, nitric oxide. At the same time that L-NAME was administered, taurine treated animals received either 1% or 2% taurine in the drinking water. As a control, 1% taurine was added to the water without L-NAME administration in order to investigate the effects of taurine on blood pressure of normal rats. The results showed that taurine increased serum levels of nitric oxide and nitric oxide synthase, inhibited the elevation of blood pressure, interfered with the activity of the renin-angiotensin-aldosterone system and minimized the elevation in serum cytokine, endothelin, neuropeptide Y and thromboxane B2. It also reduced oxygen derived free radical generation, upregulated the antioxidant defenses and inhibited the proliferation of vascular smooth muscle cells. These data indicate that taurine benefits hypertensive rats, with 2% taurine mediating greater improvement than 1% taurine.

Keywords

Nitric Oxide Model Group Serum Content VSMC Proliferation Taurine Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allen JC, Navran SS, Kahn AM (1986) Na+-K+-ATPase in vascular smooth muscle. Am J Physiol 250:C536–C539PubMedGoogle Scholar
  2. Böger, RH, Bode-Böger SM, Gerecke U, Frölich JC (1994) Long term administration of L-arginine, L-NAME and the exogeneous NO donor molsidomine modulate urinary nitrate and cyclic GMP excretion in rats-correlation which vascular reactivity. Cardiovas Res 28:494–499CrossRefGoogle Scholar
  3. Dunn WR, Gardiner SM (1995) NO evidence for vascular remodelling during hypertension induced by chronic inhibition of nitric oxide synthase in Brattleboro rats. Hypertension 13: 849–857CrossRefGoogle Scholar
  4. Fujita T, Ando K, Noda H, Ito Y, Sato Y (1987) Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 75:525–532PubMedGoogle Scholar
  5. Hanna J, Chahine R, Aftimos G, Nader M, Mounayar A, Esseily F, Chamat S (2004) Protective effect of taurine against free radicals damage in the rat myocardium. Exp Toxicol Pathol 56:189–194PubMedCrossRefGoogle Scholar
  6. Jin QG, Deng RH, Li NC (2001) Effects of taurine on secretion of cardiovascular systematic regulatory peptide in heavy stress training rats. Chinese J Sports Med 20:126–131Google Scholar
  7. Ke YH, Qu SB (2003) Effects of mediodespidine caps on AngII and Ald in renal vascular hypertensive rats. Chinese Exp Pharmacol J Trad Chinese Med Formulae 9:51–52Google Scholar
  8. Lahera V, Salazar J, Salon MG, Romer JC (1992) Deficient production of nitric oxide induces volume dependent hypertension. Hypertension 10(Suppl 7):173–177Google Scholar
  9. Li J, Hua Q, Liu RK (2002) Sodium diuresis polypeptides and hypertension. Chinese J Med Guide 4:295–297Google Scholar
  10. Liu RM, Xia YF, Chen SJ, Zhai HX, Tong WR (2003) Variations of plasma NPY and neurotensin in hypertensive patients and its significance. Chinese Heart J 15:126–128Google Scholar
  11. Paakkari P, Paakkari I, karppanen H, Paasonen MK (1983) Mechanisms of inhibitory cardiovascular effects of taurine and homotaurine. Acta Med Scand 677:134–137Google Scholar
  12. Schaffer SW, Azuma J (1992) Review: myocardial physiological effects of taurine and their significance. Adv Exp Biol Med 315:105–120Google Scholar
  13. Trachtman H, Pizzo RD, Rao P, Rujikarn N, Sturman JA (1998) Taurine lowers blood pressure in the spontaneously hypertensive rats by a catecholamine independent mechanism. Am J Hypertents 2:909–912Google Scholar
  14. Wu JM, Cheng T, Tang CS (1991) Effects of Mg2+ and taurine on proliferation effects of endothelin on VSMC. J Peking Univ Heal Sci 5:351–352Google Scholar
  15. Yu WJ, Yao XH and Hou YJ, Guo LF, Zhang LK, Tang CY (2000) Effects of taurine on L-Arg/NO pathway of akaryocytes in insulin resistant rats caused by fructose. Chinese Pathophysiol J 16:1202–1206Google Scholar
  16. Zhang X, Tenner TE Jr, Lombardini JB (1999) Inhibition of rat vascular smooth muscle cell prolife-ration by taurine and taurine analogues. Biochem Pharmacol 11:1331–1339CrossRefGoogle Scholar
  17. Zheng M, Wu LJ, Li ZL, Yin SH, Bao CY (2003) Effects of taurine on serum and cardiac muscle Agt II and aldosterone in renal hypertensive rats. Chinese J Angiocarpy 8:313Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Jianmin Hu
    • 1
  • Xingli Xu
  • Jiancheng Yang
  • Gaofeng Wu
  • Changmian Sun
  • Qiufeng Lv
  1. 1.College of Animal Science and Veterinary MedicineShenyang Agricultural UniversityShenyangChina

Personalised recommendations