Antihypertensive Effect of Taurine in Rat
To investigate the effect of taurine on hypertension, a rat model of hypertension was produced by administering N-nitro-L-arginine methylester (L-NAME) to reduce the levels of the vasodilator, nitric oxide. At the same time that L-NAME was administered, taurine treated animals received either 1% or 2% taurine in the drinking water. As a control, 1% taurine was added to the water without L-NAME administration in order to investigate the effects of taurine on blood pressure of normal rats. The results showed that taurine increased serum levels of nitric oxide and nitric oxide synthase, inhibited the elevation of blood pressure, interfered with the activity of the renin-angiotensin-aldosterone system and minimized the elevation in serum cytokine, endothelin, neuropeptide Y and thromboxane B2. It also reduced oxygen derived free radical generation, upregulated the antioxidant defenses and inhibited the proliferation of vascular smooth muscle cells. These data indicate that taurine benefits hypertensive rats, with 2% taurine mediating greater improvement than 1% taurine.
KeywordsNitric Oxide Model Group Serum Content VSMC Proliferation Taurine Administration
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- Jin QG, Deng RH, Li NC (2001) Effects of taurine on secretion of cardiovascular systematic regulatory peptide in heavy stress training rats. Chinese J Sports Med 20:126–131Google Scholar
- Ke YH, Qu SB (2003) Effects of mediodespidine caps on AngII and Ald in renal vascular hypertensive rats. Chinese Exp Pharmacol J Trad Chinese Med Formulae 9:51–52Google Scholar
- Lahera V, Salazar J, Salon MG, Romer JC (1992) Deficient production of nitric oxide induces volume dependent hypertension. Hypertension 10(Suppl 7):173–177Google Scholar
- Li J, Hua Q, Liu RK (2002) Sodium diuresis polypeptides and hypertension. Chinese J Med Guide 4:295–297Google Scholar
- Liu RM, Xia YF, Chen SJ, Zhai HX, Tong WR (2003) Variations of plasma NPY and neurotensin in hypertensive patients and its significance. Chinese Heart J 15:126–128Google Scholar
- Paakkari P, Paakkari I, karppanen H, Paasonen MK (1983) Mechanisms of inhibitory cardiovascular effects of taurine and homotaurine. Acta Med Scand 677:134–137Google Scholar
- Schaffer SW, Azuma J (1992) Review: myocardial physiological effects of taurine and their significance. Adv Exp Biol Med 315:105–120Google Scholar
- Trachtman H, Pizzo RD, Rao P, Rujikarn N, Sturman JA (1998) Taurine lowers blood pressure in the spontaneously hypertensive rats by a catecholamine independent mechanism. Am J Hypertents 2:909–912Google Scholar
- Wu JM, Cheng T, Tang CS (1991) Effects of Mg2+ and taurine on proliferation effects of endothelin on VSMC. J Peking Univ Heal Sci 5:351–352Google Scholar
- Yu WJ, Yao XH and Hou YJ, Guo LF, Zhang LK, Tang CY (2000) Effects of taurine on L-Arg/NO pathway of akaryocytes in insulin resistant rats caused by fructose. Chinese Pathophysiol J 16:1202–1206Google Scholar
- Zheng M, Wu LJ, Li ZL, Yin SH, Bao CY (2003) Effects of taurine on serum and cardiac muscle Agt II and aldosterone in renal hypertensive rats. Chinese J Angiocarpy 8:313Google Scholar