Taurine 7 pp 57-63 | Cite as

Taurine Suppresses Pressor Response Through the Inhibition of Sympathetic Nerve Activity and the Improvement in Baro-Reflex Sensitivity of Spontaneously Hypertensive Rats

  • Takuzo Hano
  • Miki Kasano
  • Hiromi Tomari
  • Naomi Iwane
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)


To investigate the effect of taurine on the sympathetic nervous system, I observed pressor responses of perfused mesenteric arteries by electrical stimulation and baro-reflex sensitivity of spontaneously hypertensive rats (SHR/Izm) and control Wistar-Kyoto rats (WKY/Izm) treated with taurine. Taurine added to the perfusate suppressed norepinephrine (NE) overflow and the pressor response mediated by electrical stimulation of isolated perfused mesenteric arteries. Taurine showed a greater suppressive effect on NE overflow and the pressor response mediated by electrical stimulation in SHR/Izm rats than in WKY/Izm rats. Increment of renal sympathetic nerve activity induced by jet-air stress was suppressed in SHR/Izm rats treated with 3% taurine. The arterial baro-reflex sensitivity was more sensitive in SHR/Izm rats treated with taurine than in those exposed to no taurine. These data suggest that taurine lowers blood pressure directly via the suppression of NE release from the peripheral sympathetic nerve and the improvement of impaired baro-reflex sensitivity.


Mesenteric Artery Pressor Response Renal Sympathetic Nerve Activity Renal Nerve Taurine Treatment 
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  1. Hano T, Rho J (1989) Norepinephrine overflow in perfused mesenteric arteries of spontaneously hypertensive rats. Hypertension 14:44–53PubMedGoogle Scholar
  2. Yamamoto J, Akabane S, Yoshimi H et al. (1985) Effects of taurine on stress-evoked hemodynamic and plasma catecholamine changes in spontaneously hypertensive rats. Hypertension 7: 913–922PubMedGoogle Scholar
  3. Trachtman H, Del Pizzo R, Rao P et al (1986) Taurine lowers blood pressure in the spontaneously hypertensive rats by a catecholamine independent mechanism. Am J Hypertens 2:909–912Google Scholar
  4. Fujita T, Sato Y (1986) Changes in blood pressure and extra cellular fluid with taurine in DOCA-salt rats. Am J Physiol 250:R1014–R1020PubMedGoogle Scholar
  5. Kasamatsu K (1996) The relationship between the reactivity of sympathetic nervous system and the development of hypertension in experimental hypertension. J Wakayama Med Soc 47:267–273Google Scholar
  6. K, Ida S, Ohkuma S (1984) Alteration of cerebral taurine biosynthesis in spontaneously hypertensive rats. J Neurochem 42:1600–1606PubMedCrossRefGoogle Scholar
  7. Fujita T, Ando K, Noda H et al. (1987) Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 75:525–532PubMedGoogle Scholar
  8. Satoh H (1998) Cardiac actions of taurine as a modulator of the ion channels. Adv Exp Med Biol 442:121–128PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Takuzo Hano
    • 1
  • Miki Kasano
  • Hiromi Tomari
  • Naomi Iwane
  1. 1.Wakayama Medical University Postgraduate School of Medicine Medical Education and Population-based MedicineWakayamaJapan

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