Modulation by Taurine of Human Arterial Stiffness and Wave Reflection
Effects of taurine (1000–2000 mg) on hemodynamic function and the arterial pulse wave were investigated for 102 healthy medical and paramedical students. The vascular parameters were generally dependent on aging, with the arterial stiffness parameters, such as baPWV, ABI and AI, are considered the indicators of “vascular aging”. Acute administration of taurine decreased BP and HR and attenuated the stiffness parameters derived from the pulse waveform. Thus, taurine can cause significant changes in the cardiovascular system and the arterial pulse wave. However, approximately 5% of the students were non-responders. This may be related to the notion that taurine would be expected to exert greater effects on the vascular functions of unhealthy individuals. Based our previous experiments, therefore, taurine plays a role in the regulation of the cardiac and vascular function.
KeywordsArterial Stiffness Pulse Wave Velocity Stiffness Parameter Augmentation Index Pulse Waveform
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- Asmer R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, Target R, Levy B (1995) Assessment of arterial distensibility by automatic pulse wave velocity measurement:validation and clinical application studies. Hypertension 26:485–490Google Scholar
- Nichols WW, O’Rourke MF (1998) McDonald’s blood flow in arteries: theoretical experimental and clinical principles. Edward Arnold, LondonGoogle Scholar
- Satoh H (1994a) Antagonistic actions of taurine on Ca2+ -induced responses in cardiac muscle cells. Jpn Heart J 35:457–458Google Scholar
- Satoh H (1994b) Cardioprotective actions of taurine against intracellular and extracellular Ca2+-induced effects. In: Huxtable RJ, Michalk D (eds) Taurine in health and disease. Plenum Press, New York, pp 181–196Google Scholar
- Satoh H (1994c) Taurine-induced hyperpolarizing shift of the reversal potential for the fast Na+ current in embryonic chick cardiomyocytes. Gen Pharmacol 26:517–521Google Scholar
- Satoh H (1994d) Regulation of the action potential configuration by taurine in guinea-pig ventricular muscle. Gen Pharmacol 25:47–52Google Scholar
- Satoh H (1998a) Modulation by taurine of the spontaneous action potentials in right atrial muscles of rat. Gen Pharmacol 30:209–212Google Scholar
- Satoh (1998c) Inhibition of the fast Na+ current by taurine in guinea pig ventricular myocytes. Gen Pharmacol 31:155–158Google Scholar
- Satoh (1999) Taurine modulates IKr but not IKs in guinea pig ventricular cardiomyocytes. Br J Pharmacol 126:87–92Google Scholar
- Sperelakis N, Satoh H (1993) Taurine effects on ion channels of cardiac muscle. In: Noble D, Earn Y (eds) Ionic channels and effect of taurine on the heart. Kluwer Academic Publishers, Boston, pp 93–118Google Scholar
- Sperelakis N, Satoh H, Bkaily G (1992) Taurine’s effects on ionic current myocardial cells. In: Schaffer SW, Lombardim B (eds) Taurine: new dimensions on its mechanisms and actions, pp 129–143Google Scholar
- Suleiman MS, Dihmis WC, Caputo M, Angelini GD, Bryan AJ (1997) Changes in myocardial concentration of glutamine and aspartate during coronary artery surgery. Am J Physiol 272:H1063–H1069Google Scholar