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Taurine 7 pp 463-472 | Cite as

Production of Reactive Oxygen and Nitrogen Species in Phagocytes is Regulated by Taurine Chloramine

  • Chaekyun Kim
  • Young-Nam Cha
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)

abstract

Taurine is abundantly present in phagocytic cells and provides protection against cytotoxicity caused by reactive oxygen species (ROS). The reaction between taurine and HOCl, a toxic product of the myeloperoxidase (MPO) system, generates a more stable and less toxic product, taurine chloramine (TauCl). TauCl has also been shown to inhibit the production of superoxide anion (O2 -) and nitric oxide (NO). In this review, we compare the effect of taurine and TauCl on the production of these reactive species in phagocytes. First, TauCl inhibit PMA-derived O2 - production and this is associated with inhibition of p47phox phosphorylation and of p47phox and p67phox translocation. Second, TauCl inhibits LPS-induced iNOS expression and NO production. This occurs by direct inhibition of Ras activation, ERK1/2 phosphorylation and NF-κB activation. Third, TauCl by itself increases the expression of heme oxygenase-1 (HO-1) and enhances HO activity. Carbon monoxide (CO), a product of HO activity, is able to inhibit both O2 - and NO production. Combined, these effects of TauCl appear to provide cytoprotection against the inadvertent cytotoxicity caused by overproduction of O2 - and NO.

Keywords

Nitric Oxide iNOS Expression Heme Oxygenase Activity Taurine Chloramine Gaseous Signal Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Chaekyun Kim
    • 1
  • Young-Nam Cha
  1. 1.Laboratory for Leukocyte Signaling Research and Center for Advanced Medical Education by BK21 ProjectIncheonKorea

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