Abstract
The present study was undertaken to evaluate effects of dietary taurine supplementation on the homeostasis of trace elements, including Se, Cu, Mn and Cr, in rats chronically consuming alcohol. Male SD rats were fed for 8 wk a liquid form of a control diet (CD), an ethanol diet (ED), or a taurine-supplemented ethanol diet (TED). Plasma Se and Mn concentrations were significantly lower in the ED rats than in the CD rats; dietary taurine supplementation corrected alcohol-induced decreases in plasma Se and Mn levels. Chronic alcohol consumption significantly increased urinary excretion of Se (a 53% increase, p<0.05), Cr (a 62% increase, p<0.05), Mn (a 45% increase, p<0.05) and Cu (a 30% increase, p<0.05) in rats. Urinary losses of these trace elements induced by chronic alcohol consumption in rats were abolished by taurine supplementation. These results suggest that taurine supplementation in rats may protect against Se, Cr and Mn insufficiency caused by chronic alcohol-mediated loss of the trace elements in the urine.
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Abstract
Aaseth J, Smith-Kielland A, Thomassen Y (1986) Selenium, alcohol and liver disease. Ann Clin Res 18:43–47
Bleich S, Degner D (2000) Reversal of ethanol-induced hepatic steatosis and lipid peroxidation by taurine: a study in rats. Alcohol Alcohol 35:215
Bullock R, Maxwell WL, Graham DI, Teasdale GM, Adams JH (1991) Glial swelling following human cerebral contusion: an ultrastructural study. J Neurol Neurosurg Psychiatry 54:427–434
Burk RF, Early DS, Hill KE, Palmer IS, Boeglin ME (1998) Plasma selenium in patients with cirrhosis. Hepatology 27:794–798
Choi MJ, Kim MJ, Chang KJ (2006) The effect of dietary taurine supplementation on plasma and liver lipid concentrations and mineral metabolism in rats fed alcohol. Adv Exp Med Biol 583:243–250
Clark LC, Combs GF, Turnbull BW, Slate EH, Chalker DK, Chow J, Davis LS, Glover RA, Graham GF, Gross EG, Krongrad A, Lesher JL, Park HK, Sanders BB, Smith CL, Taylor JR (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 276:1957–1963
Dawson RJ, Liu S, Jung B, Messina S, Eppler B (2000) Effects of high salt diets and taurine on the development of hypertension in the strokeprone spontaneously hypertensive rats. Amino Acids 19:643
Dogru-Abbasoglu S, Kanbagli O, Balkan J, Cevikbas U, Aykac-Toker G, Uysal M (2001) The protective effect of taurine against thioacetamide hepatotoxicity of rats. Hum Exp Toxicol 20:23–27
Faizallah R, Morris AI, Krasner N, Walker RJ (1986) Alcohol enhances vitamin C excretion in the urine. Alcohol Alcohol 21:81–84
González-Reimers E, Conde-Martel A, Santolaria-Fernandez F, Martinez-Riera A, Rodriguez-Moreno F, González-Hernández T, Castro-Aleman VV (1993) Relative and combined roles of ethanol and protein malnutrition on muscle zinc, potassium, copper, iron, and magnesium. Alcohol Alcohol 28:311–318
González-Reimers E, Martinez-Riera A, Santolaria-Fernandez F, Mas-Pascual A, Rodriguez-Moreno F, Galindo-Martin L, Molina-Perez, Barros-Lopez N (1998) Relative and combined effects of ethanol and protein deficiency on zinc, iron, copper, and manganese contents in different organs and urinary and fecal excretion. Alcohol 16:7–12
Green TR, Fellman JH, Eicher AL, Pratt KL (1991) Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Biochem Biophys Acta 1073:91
Keating E, Lemos C, Goncalves P, Martel F (2007) Acute and chronic effects of some dietary bioactive compounds on folic acid uptake and on the expression of folic acid transporters by the human trophoblast cell line BeWo. J Nutr Biochem 23:1–10
Kerai MD, Waterfield CJ, Kenyon SH, Asker DS, Timbrell JA (1998) Taurine:protective properties against ethanol-induced hepatic steatosis and lipid perowidation during chronic ethanol consumption in rats. Amino Acids 15:53–76
Kim BJ, Hood BL, Richard AA Hardwick JP, Conrads TP, Veenstra TD, Song BJ (2006) Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells. Proteomics 6:1250–1260
Levander OA (1987) A global view of human selenium nutrition. Annu Rev Nutr. 7:227–250
Lieber CS, DeCarli LM (1986) The feeding of ethanol in liquid diets. Alcohol Clin Exp Res 10:550–553
Lindros KO, Jarvelainen HA (1998) A new oral low-carbohadrate alcohol liquid diet producing liver lesions: a preliminary account. Alcohol Alcohol 33:347–353
Lumeng L, Bosron WF, Li TK (1980) Rate-determining factors for ethanol metabolism in vivo during fasting. Adv Exp Med Biol 132:489–496
Marotta F, Labadarios D, Frazer L, Girdwood A, Marks IN (1994) Fat-soluble vitamin concentration in chronic alcohol-induced pancreatitis. Relationship with steatorrhea. Dig Dis Sci 39:993–998
Pushpakiran G, Mahalakshmi K, Anuradha CV (2004) Taurine restores ethanol-induced depletion of antioxidants and attenuates oxidative stress in rat tissues. Amino Acid 27:91–96
Reicks M, Rader JI (1990) Effects of dietary tin and copper on rat hepatocellular antioxidant protection. Proc Soc Exp Biol Med 195:123–128
RodrÃguez-Moreno F, González-Reimers E, Santolaria-Fernández F, Galindo-MartÃn L, Hernandez-Torres O, Batista-López N, Molina-Perez M (1997) Zinc, copper, manganese, and iron in chronic alcoholic liver disease. Alcohol 14:39–44
Ryle PR, Thomson AD (1984) Nutrition and vitamins in alcoholism. Contemp Issues Clin Biochem 1:188–224
Solomons NW (1980) Zinc and copper in hepatobiliary and pancreatic disorders. In: Karcioglu ZA, Sarper RM et al. (eds) Zinc and copper in medicine, Springfield, IL:Charles C. Thomas, pp 317–346
Trachtman H, Futterweit S, Maesaka J, Ma C, Valderrama E, Fuchs A, Tarectecan AA, Rao PS, Sturman JA, Boles TH, Fu MX, Bayes J (1995) Taurine ameliorates chronic streptozotocin-induced diabetic nephropathy in rats. Am J Physiol 269:F429
Zarski JP, Arnaud J, Dumolard L, Favier A, Rachail M (1985) Trace elements (zinc, copper, manganese) in alcoholic cirrhosis: effect of chronic alcoholism. Gastroenterol Clin Biol 9:664–669
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Park, T., Cho, K., Park, SH., Lee, DH., Kim, H.W. (2009). Taurine Normalizes Blood Levels and Urinary Loss of Selenium, Chromium, and Manganese in Rats Chronically Consuming Alcohol. In: Azuma, J., Schaffer, S.W., Ito, T. (eds) Taurine 7. Advances in Experimental Medicine and Biology, vol 643. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75681-3_42
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DOI: https://doi.org/10.1007/978-0-387-75681-3_42
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