The Effects of Dietary Taurine Supplementation on Plasma and Liver Lipid in Ovariectomized Rats
The purpose of this study was to investigate the effect of dietary taurine supplementation on plasma and liver lipid content in ovariectomized (OVX) rats. Forty female Sprague-Dawley rats were divided into two groups, one that was OVX and the other sham operated (Sham). They were further divided into either control or taurine supplemented dietary (2.0 g/100 g diet) subgroups. Plasma lipids (Total cholesterol, HDL-cholesterol, and Triglycerides) and liver lipids were determined by using commercial kits (Wako Pure Chemical, Osaka). LDL-cholsterol content was estimated by the equation of fridewald et al 1972 . There were no significant differences in body weight gain and food intake between the OVX or controls rats that were either control or taurine fed, but body weight gain was higher in the OVX groups. Food intake and the food efficiency ratio were not significantly different between the dietary subgroups. The concentrations of plasma total cholesterol and triglycerides were lower in the taurine, OVX group while the HDL-cholesterol and the LDL-cholesterol levels were not reduced in the two taurine fed subgroups. There were no significant differences in liver cholesterol and triglyceride content between the control, OVX and the taurine, OVX rats. There were no significant differences in the atherogenic index between control, OVX and taurine, OVX groups. These results confirmed that taurine exerts some beneficial effects on hypercholesterolemia and hypertriglyceridemia of the OVX rats.
KeywordsLiver Lipid Taurine Supplementation Dietary Taurine Fecal Bile Acid Excretion Dietary Taurine Supplementation
Unable to display preview. Download preview PDF.
- Fridewald WT, Lavy RI, Fredricson DS(1972) Estimation of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502Google Scholar
- Furukawa S, Katto M, Kouyama H, Nishida I, Kikumori M, Taniguchi Y, Toda T, Araki H(1991) Repeated dose toxicity study of intravenous treatment with taurine for 13 weeks and recovery test for 5 weeks in rat. J. Jpn Pharmacol Ther 19:275–306Google Scholar
- Kushwaha RS, Born KM(1991) Effect of estrogen and progesterone on the hepatic cholesterol 7-alpha-hydroxylase activity in ovariectomized baboons. Biochim Biophys Act 1084:300–302Google Scholar
- Murakami S, Yamagishi I, Asami Y, Ohta Y, Toda Y Nara Y, Yamori Y(1996) Hypolipidemic effect of taurine in stroke-prone spontaneously hypertensive rats. Pharmacolog 52:303–313Google Scholar