Taurine 7 pp 37-46 | Cite as

Vascular Modulation of Rat Aorta by Taurine

  • Seiichiro Nishida
  • Hiroyasu Satoh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)


Taurine is found in high concentration in smooth muscle and heart muscle (approximately 10–20 mM). We found that taurine affects NE- and KCl-induced vasoconstriction. The mechanisms regulating these vasoconstrictions mostly involve Ca2+ channels and EDRF(NO). Taurine exerted either a vasodilation or vasoconstriction depending on cellular Ca2+ concentration. When vascular tone was excessively low, taurine promoted vasoconstriction allowing the maintenance of blood pressure. On the other hand, taurine dilates vessels to increase blood flow during ischemia or hypoxia. Thus, taurine modulates vascular wall tone to maintain blood flow. These results indicate that taurine plays an important homeostatic function on vascular smooth muscles as well as cardiac muscle.


Vascular Smooth Muscle Myosin Light Chain Ginkgo Biloba Extract Aortic Strip Normal Krebs Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Seiichiro Nishida
  • Hiroyasu Satoh
    • 1
  1. 1.Department of PharmacologyNara Medical UniversityNaraJapan

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