Abstract
Taurine is found in high concentration in smooth muscle and heart muscle (approximately 10–20 mM). We found that taurine affects NE- and KCl-induced vasoconstriction. The mechanisms regulating these vasoconstrictions mostly involve Ca2+ channels and EDRF(NO). Taurine exerted either a vasodilation or vasoconstriction depending on cellular Ca2+ concentration. When vascular tone was excessively low, taurine promoted vasoconstriction allowing the maintenance of blood pressure. On the other hand, taurine dilates vessels to increase blood flow during ischemia or hypoxia. Thus, taurine modulates vascular wall tone to maintain blood flow. These results indicate that taurine plays an important homeostatic function on vascular smooth muscles as well as cardiac muscle.
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References
Azuma J, Sawamura A, Awata N (1992) Usefulness of taurine in chronic heart failure and its prospective application. Jpn Circ J 56:95–99
Franconi F, Glotti A, Manzini S, Martini F, Stendardi I, Zilletti L (1982) The effects of taurine on high potassium- and noradrenalline- induced contraction in rabbit ear artery. Br J Pharmacol 75:605–612
Hirano K (2007) Current topics in the regulatory mechanism underlying the Ca2+ sensitization of the contractile apparatus in vascular smooth muscle. J Pharmacol Sci 104:109–115
Jerlich A, Fritz G, Kharrazi H, Hammel M, Tschabuschnig S, Glatter O, Schaur RJ (2000) Comparizon of HOCl traps with myeloperoxidase inhibitors in prevention of low density lipoprotein oxidation. Biochim Biophys Acta 80:27–32
Kamata K, Sugiura M, Kojima S, Kasuya Y (1996) Restoration of endothelium-dependent relaxation in both hypercholesterolemia and diabetes by chronic taurine. Eur J Pharmacol 303:47–53
Kearns S, Dawson R Jr (2000) Cytoprotective effect of taurine against hypochlorous acid toxicity to PC12 cells. Adv Exp Med Biol 483:563–570
Murakami S, Kondo Y, Tomisawa K, Nagate T (1999) Prevention of atherosclerotic lesion development in mice by taurine. Drug Exp Clin Res 25:227–234
Nishida S, Satoh H (2003) Mechanisms for vasodilations induced by Ginkgo biloba extract and its main constitute bilobalide in rat aorta. Life Sci 72:2659–2667
Nishida S, Satoh H (2004) Comparative vasodilating actions among terpenoids and flavonoids contained in Ginkgo biloba extract. Clinica Chimica Acta 339:129–133
Risori MT, Verdetti J (1991) Effects of taurine on rat aorta in vitro. Fundam Clin Pharmcol 5: 245–258
Satoh H (1994a) Antagonistic actions of taurine on Ca2+ -induced responses in cardiac muscle cells. Jpn Heart J 35:457–458
Satoh H (1994b) Cardioprotective actions of taurine against intracellular and extracellular Ca2+-induced effects. In: Huxtable RJ, Michalk D (eds) Taurine in health and disease. Plenum Press, New York, pp 181–196
Satoh H (1994c) Taurine-induced hyperpolarizing shift of the reversal potential for the fast Na+ current in embryonic chick cardiomyocytes. Gen Pharmacol 26:517–521
Satoh H (1994d) Regulation of the action potential configuration by taurine in guinea-pig ventricular muscle. Gen Pharmacol 25:47–52
Satoh H (1995a) Regulation by taurine of the spontaneous activity in young embryonic chick cardiomyocytes. J Cardiovasc Pharmacol 25:3–8
Satoh H (1995b) A dual actions of taurine on the delayed rectifier K+ current in young embryonic chick cardiomyocytes. Amino Acids 9:235–246
Satoh H (1995c) Electropysiological actions of taurine on spontaneously beating rabbit sino-atrial nodal cells. Jpn J Pharmacol 67:29–34
Satoh H (1996) Direct inhibition by taurine of the ATP-sensitive K+ channel in guinea pig ventricular cardiomyocytes. Gen Pharmacol 27:625–627
Satoh H (1998a) Modulation by taurine of the spontaneous action potentials in right atrial muscles of rat. Gen Pharmacol 30:209–212
Satoh H (1998b) Inhibition by taurine of the inwardly rectifying K+ current in guinea pig ventricular cardiomyocytes. Eur J Pharmacol 346:309–313
Satoh H (1998c) Inhibition of the fast Na+ current by taurine in guinea pig ventricular myocytes. Gen Pharmacol 31:155–158
Satoh H (1999) Taurine mudulates IKr but not IKs in guinea pig ventricular cardiomyocytes. Br J Pharmacol 126:87–92
Satoh H (2001) [Ca2+]i-dependent actions of taurine in spontaneously beating rabbit sino-atrial nodal cells. Eur J Pharmacol 424:19–25
Satoh H (2003) Electropharmacology of taurine on the hyperpolarization-activated inward current and the sustained inward current in spontaneous beating rat sino-atrial nodal cells. J Pharmacol Sci 91:229–238
Satoh H, Horie M (1997) Actioin of taurine on the L-type Ca2+ channel current in the guinea pig ventricular cardiomyocytes. J Cardiovasc Pharmacol 30:711–716
Satoh H, Sperelakis N (1992) Taurine inhibition of Na+ current in embryonic chick ventricular myocytes. Eur J Pharmocol 218:83–89
Satoh H, Sperelakis N (1993) Taurine effects on Ca2+ currents in young embryonic chick cardiomyocytes. Eur J Pharmacol 231:443–449
Satoh H, Sperelakis N (1998) Review of some actions of taurine on ion channels of cardiac muscle cells and others. Gen Pharmacol 30:451–463
Satoh H, Nakatani A, Tanaka T, Haga T (2002) Cardiac functions and taurine’s actions at different extracellular calcium concentrations in forced swimming stress-loaded rats. Biol Trac Ele Res 87:171–182
Shirao S, Kashiwagi S, Sato M, Miwa S, Nakao F, Kurokawa T, Todoroki-Ikeda N, Mogami K, Mizulami Y, Kuriyama S, Haze K, Suzuki M, Kobayashi S (2002) Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C. Circ Res 91:112–119
Song D, O’Regan MH, Phillis JW (1998) Mechanisms of amino acid release from the isolated anoxic/reperfused rat heart. Eur J Pharmacol 351:313–322
Sperelakis N, Satoh H (1993) Taurine effects on ion channels of cardiac muscle. In: Noble D, Earn Y (eds) Ionic channels and effect of taurine on the heart. Kluwer Academic Publishers, Boston, pp 93–118
Sperelakis N, Satoh H, Bkaily G (1992) Taurine’s effects on ionic current myocardial cells. In: Schaffer SW, Lombardim B (eds) Taurine: new dimensions on its mechanisms and actions, pp 129–143
Takihara K, Azuma J, Awata N, Ohta H, Hamaguchi T, Sakamura A, Tanaka Y, Kishimoto S, Sperelakis N (1986) Beneficial effects of taurine in rabbits with chronic congestive heart failure. Am Heart J 112:1278–1284
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Nishida, S., Satoh, H. (2009). Vascular Modulation of Rat Aorta by Taurine. In: Azuma, J., Schaffer, S.W., Ito, T. (eds) Taurine 7. Advances in Experimental Medicine and Biology, vol 643. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75681-3_4
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DOI: https://doi.org/10.1007/978-0-387-75681-3_4
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