Taurine 7 pp 381-388 | Cite as

Effect of PTP1B Inhibitors and Taurine on Blood Lipid Profiles in Adolescent Obesity

  • Sun Hee Cheong
  • Hyeongjin Cho
  • Kyung Ja Chang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)


The purpose of this study was to investigate the effect of protein tyrosine phosphatase 1B (PTP1B) inhibitors and taurine on blood lipid profiles of the obese adolescent. Three week-old thirty-six male Sprague-Dawley rats were randomly assigned to six groups (high fat diet (HFD) group, HFD group; high fat diet + taurine group, HFD + taurine (TR) group; high fat diet + PTP1B inhibitor A (A) group, HF + A group; high fat diet + PTP1B inhibitor B, HF + B group; high fat diet + PTP1B inhibitor A + taurine group, HF + A + TR group; and high fat diet + PTP1B inhibitor B + taurine group, HF+B+TR group). The body weight of the HF+A and HF \ + A + TR groups were significantly reduced compared to those of the other groups, the exception being the HF + B + TR group. Serum triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels of the HF + A + TR group were significantly reduced compared to those of the other groups. However, serum high density lipoprotein cholesterol (HDL-C) levels in HF + B + TR group was significantly reduced compared those of the HFD and HF + TR groups. Therefore, these results suggest a possible effect of PTP1B inhibitors and taurine on blood triglyceride, total cholesterol and low density lipoprotein cholesterol in the obese adolescent.


High Density Lipoprotein Cholesterol Retinyl Palmitate Taurine Supplementation Serum High Density Lipoprotein Cholesterol Dietary Taurine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Sun Hee Cheong
    • 1
  • Hyeongjin Cho
  • Kyung Ja Chang
  1. 1.Department of Food and NutritionInha UniversityKorea

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