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Taurine 7 pp 369–379Cite as

The Effects of Taurine, Hypotaurine, and Taurine Homologs on Erythrocyte Morphology, Membrane Fluidity and Cytoskeletal Spectrin Alterations Due to Diabetes, Alcoholism and Diabetes-Alcoholism in the Rat

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Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 643)

Abstract

Taurine (TAU) and compounds representing a TAU analog (hypotaurine $=$ HYTAU) or homolog (aminomethanesulfonic acid $=$ AMSA, homotaurine $=$ HMTAU) were tested for their counteracting effects against alterations in erythrocyte (RBC) morphology, membrane fluidity and cytoskeletal spectrin distribution due to diabetes, alcoholism and diabetes-alcoholism in male Goto-Kakizaki rats (made diabetic with a high fat diet and alcoholic upon feeding on a flavored alcohol solution) and Wistar-Kyoto rats (serving as controls). Both diabetes and alcoholism changed the RBC discoidal biconcave shape to a spiculated one, lowered membrane fluidity, and caused spectrin to become marginalized. While AMSA and HYTAU returned the RBC shape to normal, HMTAU made it only discoidal, and TAU was without effect. All test compounds, but TAU, maintained the membrane fluidity normal; and HYTAU and AMSA, but not TAU or HMTAU, kept spectrin uniformly distributed. The noted effects were correlated with compound structure and RBC values for malondialdehyde and cholesterol/phospholipid ratio.

Keywords

  • Sulfur Compound
  • Membrane Fluidity
  • Chronic Alcoholism
  • Normal RBCs
  • Isotonic Phosphate Buffer Saline

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • DOI: 10.1007/978-0-387-75681-3_38
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Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions,St. John’s University, Jamaica, New York, USA

    Davekanand Gossai

Authors
  1. Davekanand Gossai
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  2. Cesar A. Lau-Cam
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Editor information

Editors and Affiliations

  1. Department Clinical Evaluation of Medicines and Therapeutics, Osaka University, 1–6 Yamada Oka, Suita Osaka, 565-0871 Japan

    Junichi Azuma

  2. Department of Pharmacology College of Medicine, University of South Alabama, 307 University blvd., Mobile, Alabama 36688, USA

    Stephen W. Schaffer

  3. Department of Pharmacology College of Medicine, University of South Alabama, 307 University blvd., Mobile, Alabama 36688, USA

    Takashi Ito

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Gossai, D., Lau-Cam, C.A. (2009). The Effects of Taurine, Hypotaurine, and Taurine Homologs on Erythrocyte Morphology, Membrane Fluidity and Cytoskeletal Spectrin Alterations Due to Diabetes, Alcoholism and Diabetes-Alcoholism in the Rat. In: Azuma, J., Schaffer, S.W., Ito, T. (eds) Taurine 7. Advances in Experimental Medicine and Biology, vol 643. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75681-3_38

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