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Taurine 7 pp 313-322 | Cite as

Effect of Taurine on Alcoholic Liver Disease in Rats

  • Gaofeng Wu
  • Jiancheng Yang
  • Changmian Sun
  • Xinhong Luan
  • Jiao Shi
  • Jianmin Hu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)

Abstract

To investigate the effect of taurine on alcoholic liver disease in rats, male Wistar rats were administered alcohol intragastrically for 3 months. The effect of β-alanine-mediated taurine depletion and taurine administration on the development of alcoholic liver disease was examined. It was found that taurine administration produced lower levels of aspartate aminotransferase and alkaline aminotransferase than that of the untreated group. In addition, the levels of hepatic total protein, glutathione and superoxide dismutase were higher in the taurine treated groups than in the untreated control or the taurine depleted group, while hepatic malondialdehyde content exhibited the opposite effect. Moreover, the content of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-α and laminin were all decreased in the taurine treated group. The pathological changes showed that the percentage of fatty degeneration and inflammation in the taurine group were less than that of the control, taurine depleted and automatic recovery groups. These in-vivo findings demonstrate that hepatic disease caused by chronic alcohol consumption can be prevented and reversed by administration of taurine.

Keywords

Hyaluronic Acid Model Group Alcoholic Liver Disease Alcohol Treatment Hepatic Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Banks MA, Porter DW, Martin WG, Castranova V (1991) Ozone induced lipid peroxidation and membrane leakage in isolated rat alveolar macrophages: protective effects of taurine. J Nutr Biochem 2: 308–313CrossRefGoogle Scholar
  2. Chen YX, Li S, Zhang XR (1999) Inhibition effects of taurine on hepatic fibrosis in rats caused by CCL4. Chinese J Digest 19:185–187Google Scholar
  3. Huxtable RJ (1992) Physiological action of taurine. Physiol Rev 72:101–163.PubMedGoogle Scholar
  4. Kerial MDJ, Waterfield CJ, Kenyon SH, Asker DS, Timbrell JA (1998) Taurine: Protective properties against ethanol-induced hepatic steatosis and lipid peroxidation during chronic ethanol consumption in rats. Amino Acids 15:53–76CrossRefGoogle Scholar
  5. Kerial MDJ, Waterfield CJ, Kenyon SH, Asker DS, Timbrell JA (1999) Reversal of ethanol-induced hepatic steatosis and lipid peroxidation by taurine: a study in rats. Alcohol and Alcoholism 34:529–541CrossRefGoogle Scholar
  6. Liu S, Zhang MX (2004) Research summarize of alcoholic liver disease. Chinese Arch. Chinese Med 22:85–86Google Scholar
  7. Polavarapu R, Spitz DR, Sim JE, Follansbee MH, Oberley LW, Rahemtulla A, Nanji AA (1998) Increase lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil. Hepatology 27: 1317–1323PubMedCrossRefGoogle Scholar
  8. Trachtman H, Futterwert C, Robert B (1993) Taurine prevents glucose-induced lipid peroxidation and increased collagen production in cultured rat mesangial cells. Biochem Biophys 191:759CrossRefGoogle Scholar
  9. Wang CH, Zhang XK, Miu YM (2002) Protective effects of taurine on hepatic mitochondria in the process of ischemia reperfusion in rats. Chinese J Integ Trad Western Med Liver Dis 2:351–354 and 357Google Scholar
  10. Wei X, Liang J, Mao DW (2004) Influence of taurine on the formation of hepatic fibrosis in rats. Chinese J Integ Trad Western Med Digest 12:6–7Google Scholar
  11. Zhou SQ, Jia CY, Gao DS (1986) Pathomorphologic observations on hepatic damages in rats caused by experimental chronic alcoholic intoxicate. Chinese J Pathol 15:136–139Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Gaofeng Wu
    • 1
  • Jiancheng Yang
  • Changmian Sun
  • Xinhong Luan
  • Jiao Shi
  • Jianmin Hu
  1. 1.College of Animal Science and Veterinary MedicineShenyang Agricultural UniversityShenyangChina

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