Taurine 7 pp 305-311 | Cite as

Taurine Depletion by β-Alanine Inhibits Induction of Hepatotoxicity in Mice Treated Acutely with Carbon Tetrachloride

  • Dalwoong Choi
  • Sun Ju Kim
  • Do Young Kwon
  • Sun Young Lee
  • Young Chul Kim
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)


We examined the effect of taurine depletion on hepatic sulfur-containing amino acid metabolism and carbon tetrachloride-induced acute liver injury. Mice were supplemented with β-alanine (3%) in drinking water for one week. β-Alanine intake significantly reduced hepatic taurine levels, but did not influence S-adenosylmethionine, S-adenosylhomocysteine, glutathione levels or methionine adenosyltransferase activity in liver. However, hepatic cysteine levels were significantly elevated by β-alanine administration. Hepatotoxicity caused by carbon tetrachloride (50 μ l/kg, ip) in mice fed β-alanine was decreased, as determined by changes in serum aspartate aminotransferase, alanine aminotransferase and sorbitol dehydrogenase activities. Hepatic glutathione and taurine levels after a carbon tetrachloride challenge were markedly increased by β-alanine exposure. The results suggest that enhanced availability of cysteine for synthesis of glutathione and/or taurine may account for the hepatoprotective effects of β-alanine against carbon tetrachloride-induced acute liver injury.


Sorbitol Dehydrogenase Taurine Level Methionine Adenosyltransferase Transsulfuration Pathway Taurine Depletion 


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Dalwoong Choi
    • 1
  • Sun Ju Kim
  • Do Young Kwon
  • Sun Young Lee
  • Young Chul Kim
  1. 1.College of Health ScienceKorea UniversityKorea

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