Taurine 7 pp 305-311 | Cite as

Taurine Depletion by β-Alanine Inhibits Induction of Hepatotoxicity in Mice Treated Acutely with Carbon Tetrachloride

  • Dalwoong Choi
  • Sun Ju Kim
  • Do Young Kwon
  • Sun Young Lee
  • Young Chul Kim
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)


We examined the effect of taurine depletion on hepatic sulfur-containing amino acid metabolism and carbon tetrachloride-induced acute liver injury. Mice were supplemented with β-alanine (3%) in drinking water for one week. β-Alanine intake significantly reduced hepatic taurine levels, but did not influence S-adenosylmethionine, S-adenosylhomocysteine, glutathione levels or methionine adenosyltransferase activity in liver. However, hepatic cysteine levels were significantly elevated by β-alanine administration. Hepatotoxicity caused by carbon tetrachloride (50 μ l/kg, ip) in mice fed β-alanine was decreased, as determined by changes in serum aspartate aminotransferase, alanine aminotransferase and sorbitol dehydrogenase activities. Hepatic glutathione and taurine levels after a carbon tetrachloride challenge were markedly increased by β-alanine exposure. The results suggest that enhanced availability of cysteine for synthesis of glutathione and/or taurine may account for the hepatoprotective effects of β-alanine against carbon tetrachloride-induced acute liver injury.


Sorbitol Dehydrogenase Taurine Level Methionine Adenosyltransferase Transsulfuration Pathway Taurine Depletion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Dalwoong Choi
    • 1
  • Sun Ju Kim
  • Do Young Kwon
  • Sun Young Lee
  • Young Chul Kim
  1. 1.College of Health ScienceKorea UniversityKorea

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