Taurine 7 pp 273-283 | Cite as

Protective Effect of Taurine against Nitrosative Stress in the Stomach of Rat with Water Immersion Restraint Stress

  • Ning Ma
  • Takeshi Sasaki
  • Hiromi Sakata-Haga
  • Ken-ichi Ohta
  • Ming Gao
  • Shosuke Kawanishi
  • Yoshihiro Fukui
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)


In the present study, we examined by immunohistochemistry the formation and distribution of 8-nitroguanine, a sensitive marker of nitrosative DNA damage, in rat stomach of rats subjected to water immersion restraint stress (WIR). WIR induced an increase in 8-nitroguanine content of gastric gland epithelium. 8-Nitroguanine immunoreactivity, which was observed mainly in the nuclei of stomach epithelium, increased with the severity of inflammation. Expression of iNOS was also observed in the inflammatory cells of lamina propria. Therefore, it is logical that iNOS-mediated nitrosative stress must participate in the development of ulcers through apoptotic cell death linked to the formation of 8-nitroguanine during chronic inflammation. Taurine administration attenuated stress-induced gastric mucosal injury. These results demonstrate that nitrosative stress participates in stress-mediated ulcer formation. Taurine exerts a prophylactic effect against mucosal lesions of the stomach caused by stress. This effect of taurine may have a potential clinical benefit in preventing gastritis associated with stress.


Gastric Mucosa Parietal Cell Nitrosative Stress Gastric Gland Gastric Mucosal Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ning Ma
    • 1
  • Takeshi Sasaki
  • Hiromi Sakata-Haga
  • Ken-ichi Ohta
  • Ming Gao
  • Shosuke Kawanishi
  • Yoshihiro Fukui
  1. 1.Department of Anatomy and Developmental Neurobiology Institute of Health BiosciencesThe University of Tokushima Graduate SchoolTokushima Japan

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