Taurine 7 pp 265-271 | Cite as

Dietary Taurine Attenuates Dextran Sulfate Sodium (DSS)-induced Experimental Colitis in Mice

  • Makoto Shimizu
  • Zhaohui Zhao
  • Yoko Ishimoto
  • Hideo Satsu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)


Effects of dietary taurine on the experimental colitis induced by dextran sulfate sodium (DSS) were studied. C57BL/6 mice administrated taurine or placebo for 5 days were given 3% DSS to induce acute. The colitis was as-sessed using indices such as diarrhea/bleeding scores, colon length change, histological score and tissue myeloperoxidase (MPO) activity. Further, tis-sue mRNA levels of interleukin (IL)-1β, tumor necrosis factor (TNF)-α and macrophage inflammatory protein (MIP)-2, were determined by real-time PCR. Taurine supplementation significantly attenuated the severity of diarrhea, colon shortening, histological score, MPO activity elevation and abnormal MIP-2 gene expression, indicating that taurine prevents DSS-induced colitis. Taurine also inhibited the TNF-α-induced secretion of IL-8 (a hu-man homologue of MIP-2) from human intestinal epithelial Caco-2 cells. Inhibition of chemokine secretion from intestinal cells may be involved in the mechanisms underlying the cytoprotective function of taurine in the intestinal epithelium.


Dextran Sulfate Sodium Taurine Supplementation Taurine Uptake Dietary Taurine Taurine Treatment 
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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Makoto Shimizu
    • 1
  • Zhaohui Zhao
  • Yoko Ishimoto
  • Hideo Satsu
  1. 1.Department of Applied Biological ChemistryThe University of TokyoTokyoJapan

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