Abstract
The taurine transporter and taurine are present in lymphocytes, where taurine functions as an antioxidant and an anti-inflammatory agent. Taurine levels are elevated in lymphocytes of subjects with major depression, but returns to control levels after treatment with the antidepressant mirtazapine. Patients (40) were diagnosed using the Diagnostic and Statistical Manual IV of the American Psychiatric Association, and the severity of their condition was determined by the Hamilton Scale of Depression. One group of patients was treated with venlafaxine and the other with venlafaxine plus Neuro-Linguistic Programming. Lymphocytes were isolated from the peripheral blood by Ficoll/Hypaque. The coexistence of the taurine transporter with a subpopulation of CD4+ and CD8+ lymphocytes was measured by immunofluorescence. The levels of the pro-inflammatory, IL-2, and the anti-inflammatory, IL-4, cytokines were determined by ELISA while plasma amino acid levels were determined by HPLC. The percentage of CD4+ cells significantly decreased after both treatments, whereas the levels of CD8+ cells remained unchanged. The taurine transporter of CD4+ and CD8+ cells decreased after integrate treatment. No differences were found in the levels of IL-2 while IL-4 levels increased after integrate treatment. The observed effects of treatment on the taurine transporter and IL-4 content might modify lymphocyte activity during depression.
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References
American Psychiatric Association (1994) American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders DSM-IV (4th ed), American Psychiatric Press, Washington, DC, USA
Anisman H, Merali Z (2002) Cytokines, stress, and depressive illness. Brain Behav Immun 16: 513–524
Capuron L, Dantzer R (2003) Cytokines and depression: the need for a new paradigm. Brain Behav Immun Suppl 1:S119–S124
Connor T, Leonard B (1998) Depression, stress and immunological activation: the role of cytokines in depressive disorders. Life Sci 62:583–606
Dunn AJ, Swiergiel AH, de Beaurepaire R (2005) Cytokines as mediators of depression: what can we learn from animal studies? Neurosci Biobehav Rev 29:891–909
Fazzino F, Urbina M, Mata S, Lima L (2006) Taurine transport and transporter localization in peripheral blood lymphocytes of controls and major depression patients. Adv Exp Med Biol 583:423–426
González A, Fazzino F, Castillo M, Mata S, Lima L (2007) Serotonin, 5-HT1A serotonin receptors and proliferation of lymphocytes in major depression patients. Neuroimmunomodulation 14: 8–15
Grimble RF (2006) The effects of sulfur amino acid intake on immune function in humans. J Nutr 136:1660S–1665S
Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56-62
Huxtable R, (1992) Physiological actions of taurine. Physiol Rev 72:101–163
Kim S, Kim H, Yang W, Kim B (1996) Protective effect of taurine on indomethacin-induced gastric mucosal injury. In: RJ Huxtable, J Azuma, K Kuriyama, M Kakagawa, A Baba (eds) Taurine, Plenum Press, New York, pp 147–155
Kubera M, Van Bockstaele D, Maes M (1999) Leukocyte subsets in treatment-resistant major depression. Pol J Pharmacol 51:547–549
Learn DB, Fried VA, Thomas EL (1990) Taurine and hypotaurine content of human leukocytes. J Leukoc Biol 48:174–182
Leonard BE (2006) HPA and immune axes in stress: involvement of the serotonergic system. Neuroimmunomodulation13:268–276
Lima L, Obregon F, Urbina M, Carreira I, Baccichet E, Pena S (2003) Taurine concentration in human blood peripheral lymphocytes: major depression and treatment with the antidepressant mirtazapine. Adv Exp Med Biol 526:297–304
Lima L, Obregon F, Matus P (1998) Taurine, glutamate and GABA modulate the outgrowth from goldfish retinal explants and its concentrations are affected by the crush of the optic nerve. Amino Acids 15:195–209
Maes M, Smith R, Scharpe S (1995) The monocyte-T-lymphocyte hypothesis of major depression. Psychoneuroendocrinology 20:111–116
Marcinkiewicz J, Grabowska A, Bereta J, Stelmaszynska T (1995) Taurine chloramine, a product of activated neutrophils, inhibits the generation of nitric oxide and other macrophage inflammatory mediators. J Leukocyte Biol 58:667–674
Marquez L, Dunford H (1994) Chlorination of taurine by myeloperoxidase; kinetic evidence for an enzyme-bound intermediate. J Biol Chem 269:7950–7956
Mosmann TR, Moore KW (1991) The role of IL-10 in crossregulation of TH1 and TH2 responses. Immunol Today 12:A49–A53
Park E, Jia J, Quinn M, Schuller-Levis G (2002) Taurine chloramine inhibits lymphocyte proliferation and decreases cytokine production in activated human leukocytes. Clin Immunol 102:179–184
Pow DV, Sullivan R, Reye P, Hermanussen S (2002) Localization of taurine transporters, taurine, and (3)H taurine accumulation in the rat retina, pituitary, and brain. Glia 37:153–168
Schiepers O, Wichers M, Maes M (2005) Cytokines and major depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 29:201–217
Schuller-Levis G, Park E (2003) Taurine: new implications for an old amino acid. FEMS Microbiol Lett 26:195–202
Schuller-Levis G, Mehta PD, Rudelli R, Sturman J (1990) Immunologic consequences of taurine deficiency in cats. J Leukoc Biol 47:321–331
Sturman JA (1993) Taurine in development. Physiol Rev 73:119–147
Syvalahti E (1994) Biological aspects of depression, Acta Psychiatr Scand Suppl 377:S11–S15
Vinton NE, Laidlaw SA, Ament ME, Kopple JD (1987) Taurine concentrations in plasma, blood cells, and urine of children undergoing long-term total parenteral nutrition. Pediatr Res 21: 399–403
Voss J, Pedersen S, Christensen S, Lambert I (2004) Regulation of the expression and subcellular localization of the taurine transporter TauT in mouse NIH3T3 fibroblasts. Eur J Biochem 271:4646–4658
Wirleitner B, Neurauter G, Nagl M, Fuchs D (2004) Down-regulatory effect of N-chlorotaurine on tryptophan degradation and neopterin production in human PBMC. Immunol Lett 93:143–149
Zorrilla E, Luborsky L, McKay J, Rosenthal R, Houldin A, Tax A, McCorkle R, Seligman D, Schmidt K (2001) The Relationship of Depression and Stressors to Immunological Assays: A Meta-Analytic Review. Brain Behav Immun 15:199
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Fazzino, F. et al. (2009). Taurine Transporter in Lymphocytes of Patients with Major Depression Treated with Venlafaxine Plus Psychotherapy. In: Azuma, J., Schaffer, S.W., Ito, T. (eds) Taurine 7. Advances in Experimental Medicine and Biology, vol 643. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75681-3_22
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DOI: https://doi.org/10.1007/978-0-387-75681-3_22
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