Taurine 7 pp 13-25 | Cite as

Taurine as the Nutritional Factor for the Longevity of the Japanese Revealed by a World-Wide Epidemiological Survey

  • Yukio Yamori
  • Longjian Liu
  • Mari Mori
  • Miki Sagara
  • Shigeru Murakami
  • Yasuo Nara
  • Shunsaku Mizushima
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)

The initial observation that taurine (T) prevented stroke in stroke-prone spontaneously hypertensive rats (SHRSP) led us to study the effects of T on cardiovascular diseases (CVD), as well as the epidemiological association of T and mortality rates, by using the data from WHO-coordinated Cardiovascular Disease and Alimentary Comparison Study, which covered 61 populations in 25 countries. In this study, 24 hour urine (24-U) samples were examined along with biomarkers of CVD risk. The mortality rate from ischemic heart disease (IHD), which was lowest among the Japanese compared to the populations of other developed countries, was positively related to total serum cholesterol (TC) and inversely related to 24-U taurine excretion (24-UT), as well as the n-3 fatty acid to total phospholipids ratio of the plasma membrane, both biomarkers of seafood intake. Analysis of 5 diet-related factors revealed that TC and BMI were positively associated with IHD mortality in both genders while Mg and T were negatively associated with IHD mortality. TC and sodium (Na) were negatively and positively associated with stroke mortality, respectively. 24-UT was negatively associated with stroke mortality. These five diet-related factors explained 61 and 49% of IHD and stroke variances in male, 63 and 36% of IHD and stroke variances in female, respectively.


Total Cholesterol Creatinine Ratio Longe Life Expectancy Stroke Mortality Cardiac Study 
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  1. Alexander RW (1995) Theodore Cooper Memorial Lecture: Hypertension and the pathogenesis of atherosclerosis, oxidative stress and the mediation of arterial inflammatory response:a new perspective. Hypertension 25:155–161PubMedGoogle Scholar
  2. Ballantyne CM, Hoogeveen RC, Bang H, Coresh J, Folsom AR, Chambless LE, Myerson M, Wu KK, Sharrett AR, Boerwinkle E (2005) Lipoprotein-associated phospholipase A2, high-sensitivity c-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the atherosclerosis risk in communities (ARIC) study. Arch Intern Med 165: 2479–2484PubMedCrossRefGoogle Scholar
  3. Chiba Y, Ando K, Fujita T (2002) The protective effects of taurine against renal damage by salt loading in Dahl salt-sensitive rats. J Hypertens 20:2269–2274PubMedCrossRefGoogle Scholar
  4. Dyer AR, Persky V, Stamler J, Paul O, Shekelle RB, Berkson DM, Lepper M, Schoenberger JA, Lindberg HA (1980) Heart rate as a prognostic factor for coronary heart disease and mortality: findings in three Chicago epidemiologic studies. Am J Epidemiol 112:736–749PubMedGoogle Scholar
  5. Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72:101–163PubMedGoogle Scholar
  6. Huxtable RJ (2000) Expanding the circle 1975–1999:Sulfur biochemistry and insights on the biological functions of taurine. Adv Exp Med Biol 483:1–25PubMedCrossRefGoogle Scholar
  7. Jacobsen JG, Smith LH (1968) Biochemistry and physiology of taurine and taurine derivatives. Physiol Rev 48:424–511PubMedGoogle Scholar
  8. Jerlich A, Fritz G, Kharrazi H, Hammel M, Tschabuschnig S, Glatter O, Schaur RJ (2000) Comparison of HOCl traps with myeloperoxidase inhibitors in prevention of low density lipoprotein oxidation. Biochem Biophys Acta 481:109–118Google Scholar
  9. Kondo Y, Toda Y, Kitajima H, Oda H, Nagate T, Kameo K, Murakami S (2001) Taurine inhibits development of atherosclerotic lesions in apolipoprotein E-deficient mice. Clin Exp Pharmacol Physiol 28:809–815PubMedCrossRefGoogle Scholar
  10. Liu L, Yamori Y (2007) Gender difference of cardiovascular diseases as a clue for healthier again: Asian food. Food Culture: Development and Education UNESCO:78–83Google Scholar
  11. Mizushima S, Moriguchi EH, Nakada Y, Gonzalez B, Nara Y, Murakami K, Horie R, Moriguchi Y, Mimura G, Yamori Y (1992) The relationship of dietary factors to cardiovascular diseases among Japanese in Okinawa and Japanese immigrants, originally from Okinawa, in Brazil. Hypertens Res 15:45–55CrossRefGoogle Scholar
  12. Murakami S, Yamagishi I, Asami Y, Ohta Y, Toda Y, Nara Y, Yamori Y (1996a) Hypolipidemic effect of taurine in stroke-prone spontaneously hypertensive rats. Pharmacology 52:303–313CrossRefGoogle Scholar
  13. Murakami S, Nara Y, Yamori Y (1996b) Taurine accelerates the regression of hypercholesterolemia in stroke-prone spontaneously hypertensive rats. Life Sci 58:1643–1651CrossRefGoogle Scholar
  14. Murakami S, Kondo Y, Toda Y, Kitajima H, Kameo K, Sakono M, Fukuda N (2002a) Effect of taurine on cholesterol metabolism in hamsters: Up-regulation of low density lipoprotein (LDL) receptor by taurine. Life Sci 70:2355–2366CrossRefGoogle Scholar
  15. Murakami S, Kondo Y, Sakurai T, Kitajima H, Nagate T (2002b) Taurine suppresses development of atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits. Atheroschlerosis 163:79–87CrossRefGoogle Scholar
  16. Nara Y, Yamori Y, Lovenberg W (1978) Effects of dietary taurine on blood pressure in spontaneously hypertensive rats. Biochem Pharmacol 27:2689–2692PubMedCrossRefGoogle Scholar
  17. Okamoto K, Aoki K (1963) Development of a strain of spontaneously hypertensive rats. Jpn Circ J 27:202–293Google Scholar
  18. Okamoto K, Yamori Y, Nagaoka A (1974) Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res 34/35:143–153Google Scholar
  19. Okamura T, Hayakawa T, Kadowaki T, Kita Y, Okayama A, Elliott P, Ueshima H, NIPPONDATA80 Research Group (2004) Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population. Am Heat J 147:1024–1032CrossRefGoogle Scholar
  20. Palatini P, Julius S (1997) Heart rate and the cardiovascular risk. J Hypertens 15:3–17PubMedCrossRefGoogle Scholar
  21. Penn MS, Chisoim GM (1994) Oxidized lipoproteins, altered cell function and atherosclerosis. Atherosclerosis 108:21–29CrossRefGoogle Scholar
  22. Sato Y, Ogata E, Fujita T (1991) Hypotensive action of taurine in DOCA-salt rats-involve-ment of sympathoadrenal inhibition and endogenous opiate. Jpn Circ J 55:500–508PubMedGoogle Scholar
  23. Schuller-Levis GB, Park E (2004) Taurine and its chloramine: Modulators of immunity. Neurochem Res 29:117–126PubMedCrossRefGoogle Scholar
  24. Tagami M, Tsukada T, Kubota A, Nara Y, Yamori Y (1993) Immunocytochemical study of cerebral perforating arteries in patients with cerebral infactions. Acta Histochem Cytoshem 26: 109–115Google Scholar
  25. Tsuboyama-Kasaoka N, Shozawa C, Sano K, Kamei Y, Kasaoka S, Hosokawa Y, Ezaki O (2006) Taurine (2-aminoethanesulfonic acid) deficiency creates a vicious circle promoting obesity. Endocrinology 147:3276–3284PubMedCrossRefGoogle Scholar
  26. Tsuji K, Yano S (1984) Taurine/cholesterol ratio of well-consumed animal foods. Sulfur Amino Acids 7:249–255Google Scholar
  27. WHO and WHO Collaborating Centers (1986) CARDIAC (Cardiovascular Diseases and Alimentary Comparison) Study Protocol. Shimane, GenevaGoogle Scholar
  28. Yamori Y (1981) Environmental influences on the development of hypertensive vascular diseases in SHR and related models, and their relation to human disease. In: Worcel M et al. (eds). New Trends in Arterial Hypertension (INSERM Symposium No. 17). Elsevier, Amsterdam: 305–320Google Scholar
  29. Yamori Y (1984) The stroke-prone spontaneously hypertensive rat: Contribution to risk factor analysis and prevention of hypertensive diseases. In: de Jong W (ed). Handbook of Hypertension. Elsevier, Amsterdam:240–255Google Scholar
  30. Yamori Y (1989) Hypertension and biological dietary markers in urine and blood: A progress report from the CARDIAC study group. In: Yamori Y and Strasser T (eds). New Horizons in Preventing Cardiovascular Diseases. Elsevier, Amsterdam:111–126Google Scholar
  31. Yamori Y (2006) Food factors for atherosclerosis prevention. Asian perspective derived from analysis of world wide dietary biomarkers. Exp Clin Cardiol 11:94–98Google Scholar
  32. Yamori Y, Hamashima Y, Horie R, Handa H, Sato M (1975) Pathogenesis of acute arterial fat deposition in spontaneously hypertensive rats. Jpn Circ J 39:601–609PubMedGoogle Scholar
  33. Yamori Y, Horie R, Nara Y, Tagami M, Kihara M, Mano M, Ishino H (1987) Pathogenesis and dietary prevention of cerebrovascular diseases in animal models and epidemiological evidence for the applicability in man. In: Yamori Y and Lenfant C (eds). Prevention of Cardiovascular Diseases, an Approach to Active Long Life. Elsevier, Amsterdam:163–177Google Scholar
  34. Yamori Y, Nara Y, Mizushima S, Mano M, Sawamura M, Kihara M, Horie R, Hatano S (1990) International cooperative study on the relationship between dietary factors and blood pressure: A report from the cardiovascular diseases and alimentary comparison study. J Cardiovas Pharmacol 16:S43–S47Google Scholar
  35. Yamori Y, Nara Y, Mizushima S, Murakami S, Ikeda K, Sawamura M, Nabika T, Horie R (1992) Gene-environment interaction in hypertension, stroke and atherosclerosis in experimental models and supportive findings from a world-wide cross-sectional epidemiological survey: A WHO-CARDIAC Study. Clin Exp Pharmacol Physiol 20:43–52Google Scholar
  36. Yamori Y, Nara Y, Ikeda K, Mizushima S (1996) Is taurine a preventive nutritional factor of cardiovascular diseases or just a biological marker of nutrition. Adv Exp Med Biol 403:623–629PubMedGoogle Scholar
  37. Yamori Y, Liu L, Ikeda K, Miura A, Mizushima S, Miki T, Nara Y (2001) Distribution of twenty-four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries: Results from the WHO-CARDIAC Study. Hypertens Res 24: 453–457PubMedCrossRefGoogle Scholar
  38. Yamori Y, Liu L, Mizushima S, Ikeda K, Nara Y and CARDIAC Study Group (2006) Male cardiovascular mortality and dietary markers in 25 population samples of 16 countries. J Hypertens 24:1499–1505Google Scholar
  39. Yokogoshi H, Mochizuki H, Nanami K, Hida Y, Miyachi F, Oda H (1999) Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet. J Nutr 129:1705–1712PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Yukio Yamori
    • 1
  • Longjian Liu
  • Mari Mori
  • Miki Sagara
  • Shigeru Murakami
  • Yasuo Nara
  • Shunsaku Mizushima
  1. 1.Mukogawa Women’s UniversityJapan

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