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Taurine 7 pp 169-179 | Cite as

Mechanism of Neuroprotective Function of Taurine

  • Jang-Yen Wu
  • Heng Wu
  • Ying Jin
  • Jianning Wei
  • Di Sha
  • Howard Prentice
  • Hsin-Hsueh Lee
  • Chun-Hua Lin
  • Yi-Hsuan Lee
  • Ling-Ling Yang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)

Abstract

Taurine has potent protective function against glutamate-induced neuronal injury presumably through its function in regulation of intracellular free calcium level, [Ca2+]i. In this communication, we report that taurine exerts its protective function through one or more of the following mechanisms: 1. Inhibition of glutamate-induced calcium influx through L-, N- and P/Q-type voltage-gated calcium channels and NMDA receptor calcium channel; 2. Attenuation of glutamate-induced membrane depolarization; 3. Prevention of glutamate-induced apoptosis via preventing glutamate-mediated down-regulation of Bcl-2; 4. Prevention of cleavage of Bcl-2 by calpain. This action of taurine is due to its inhibition on glutamate induced calpain activation. Based on these observations, we propose that taurine protects neurons against glutamate-induced neurotoxicity in part, by preventing glutamate-induced membrane depolarization, elevation of [Ca2+]i, activation of calpain, reduction of Bcl-2 and apoptosis.

Keywords

NMDA Receptor Neuroprotective Function Primary Neuronal Cell Culture Intracellular Free Calcium Level Intracellular Calcium Accumulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Jang-Yen Wu
    • 1
  • Heng Wu
  • Ying Jin
  • Jianning Wei
  • Di Sha
  • Howard Prentice
  • Hsin-Hsueh Lee
  • Chun-Hua Lin
  • Yi-Hsuan Lee
  • Ling-Ling Yang
  1. 1.Department of Biomedical ScienceFlorida Atlantic UniversityBoca RatonUSA

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