Taurine 7 pp 145-156 | Cite as

Perinatal Taurine Alters Arterial Pressure Control and Renal Function in Adult Offspring

  • Sanya Roysommuti
  • Wichaporn Lerdweeraphon
  • Pisamai Malila
  • Dusit Jirakulsomchok
  • J. Michael Wyss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)


The present study investigates the effect of perinatal taurine exposure on renal function in adult, female rats on a high sugar diet. Perinatal taurine depleted (TD), supplemented (TS) or untreated control (C) female offspring were fed normal rat chow and tap water (CW,TDW or TSW) or tap water with 5% glucose (CG, TDG or TSG) after weaning. At 7–8 weeks of age, renal function was studied in the conscious, restrained rats. Mean arterial pressure was significantly higher in TDW, TDG, and TSG rats. Plasma sodium concentration was significantly lower in all glucose treated animals, but the greatest decrease was in TDW rats. Basal renal blood flow was lowest in TSW and TSG, and the responses to a saline load were also lowest in those two groups. These changes were consistent with increased renal vascular resistance. The basal glomerular filtration rate was lowest in TSW, but the responses to a saline load were similar in all of the groups. Water excretion was lower in TSG and TSW, consistent with increased renal tubular water reabsorption. These data suggest that perinatal taurine exposure alters normal renal function and renal responses to dietary sugar in adult female offspring.


Adult Offspring Renal Vascular Resistance Taurine Supplementation Nephron Number Plasma Sodium Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Sanya Roysommuti
    • 1
  • Wichaporn Lerdweeraphon
  • Pisamai Malila
  • Dusit Jirakulsomchok
  • J. Michael Wyss
    • 1
  1. 1.Department of Physiology Faculty of MedicineKhon Kaen UniversityThailand

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