Taurine 7 pp 145-156 | Cite as

Perinatal Taurine Alters Arterial Pressure Control and Renal Function in Adult Offspring

  • Sanya Roysommuti
  • Wichaporn Lerdweeraphon
  • Pisamai Malila
  • Dusit Jirakulsomchok
  • J. Michael Wyss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)


The present study investigates the effect of perinatal taurine exposure on renal function in adult, female rats on a high sugar diet. Perinatal taurine depleted (TD), supplemented (TS) or untreated control (C) female offspring were fed normal rat chow and tap water (CW,TDW or TSW) or tap water with 5% glucose (CG, TDG or TSG) after weaning. At 7–8 weeks of age, renal function was studied in the conscious, restrained rats. Mean arterial pressure was significantly higher in TDW, TDG, and TSG rats. Plasma sodium concentration was significantly lower in all glucose treated animals, but the greatest decrease was in TDW rats. Basal renal blood flow was lowest in TSW and TSG, and the responses to a saline load were also lowest in those two groups. These changes were consistent with increased renal vascular resistance. The basal glomerular filtration rate was lowest in TSW, but the responses to a saline load were similar in all of the groups. Water excretion was lower in TSG and TSW, consistent with increased renal tubular water reabsorption. These data suggest that perinatal taurine exposure alters normal renal function and renal responses to dietary sugar in adult female offspring.


Adult Offspring Renal Vascular Resistance Taurine Supplementation Nephron Number Plasma Sodium Concentration 


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  1. Aerts L, Van Assche FA (2002) Taurine and taurine-deficiency in the perinatal period. J Perinat Med 30:281–286PubMedCrossRefGoogle Scholar
  2. Anuradha CV, Balakrishnan SD (1999) Taurine attenuates hypertension and improves insulin sensitivity in the fructose-fed rat, an animal model of insulin resistance. Can J Physiol Pharmacol 77:749–754PubMedCrossRefGoogle Scholar
  3. Barker DJ (2007) Obesity and early life. Obes Rev 8 Suppl 1:45–49PubMedCrossRefGoogle Scholar
  4. Barker DJ, Eriksson JG, Forsen T, Osmond C (2002) Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol 31:1235–1239PubMedCrossRefGoogle Scholar
  5. Cruz CI, Ruiz-Torres P, del Moral RG, Rodriguez-Puyol M, Rodriguez-Puyol D (2000) Age-related progressive renal fibrosis in rats and its prevention with ACE inhibitors and taurine. Am J Physiol Renal Physiol 278:F122–F129PubMedGoogle Scholar
  6. Cusi D, Bianchi G (1991) The kidney in the pathogenesis of hypertension. Semin Nephrol 11: 523–527PubMedGoogle Scholar
  7. Dawson R Jr, Liu S, Eppler B, Patterson T (1999) Effects of dietary taurine supplementation or deprivation in aged male Fischer 344 rats. Mech Ageing Dev 107:73–91CrossRefGoogle Scholar
  8. Eppler B, Dawson R, Jr. (2001) Dietary taurine manipulations in aged male Fischer 344 rat tissue: taurine concentration, taurine biosynthesis, and oxidative markers. Biochem Pharmacol 62: 29–39PubMedCrossRefGoogle Scholar
  9. Franconi F, Loizzo A, Ghirlanda G, Seghieri G (2006) Taurine supplementation and diabetes mellitus. Curr Opin Clin Nutr Metab Care 9:32–36PubMedCrossRefGoogle Scholar
  10. Gopalakrishnan GS, Gardner DS, Dandrea J, Langley-Evans SC, Pearce S, Kurlak LO, Walker RM, Seetho IW, Keisler DH, Ramsay MM, Stephenson T, Symonds ME (2005) Influence of maternal pre-pregnancy body composition and diet during early-mid pregnancy on cardiovascular function and nephron number in juvenile sheep. Br J Nutr 94:938–947PubMedCrossRefGoogle Scholar
  11. Grisk O, Kloting I, Exner J, Spiess S, Schmidt R, Junghans D, Lorenz G, Rettig R (2002) Long-term arterial pressure in spontaneously hypertensive rats is set by the kidney. J Hypertens 20:131–138PubMedCrossRefGoogle Scholar
  12. Hall JE (2003) The kidney, hypertension, and obesity. Hypertension 41:625–633PubMedCrossRefGoogle Scholar
  13. Hall JE, Guyton AC, Brands MW (1996) Pressure-volume regulation in hypertension. Kidney Int Suppl 55:S35–S41PubMedGoogle Scholar
  14. Hall JE, Mizelle HL, Brands MW, Hildebrandt DA (1992) Pressure natriuresis and angiotensin II in reduced kidney mass, salt-induced hypertension. Am J Physiol 262:R61–R71PubMedGoogle Scholar
  15. Harada H, Kitazaki K, Tsujino T, Watari Y, Iwata S, Nonaka H, Hayashi T, Takeshita T, Morimoto K, Yokoyama M (2000) Oral taurine supplementation prevents the development of ethanol-induced hypertension in rats. Hypertens Res 23:277–284PubMedCrossRefGoogle Scholar
  16. Harada H, Tsujino T, Watari Y, Nonaka H, Emoto N, Yokoyama M (2004) Oral taurine supplementation prevents fructose-induced hypertension in rats. Heart Vessels 19:132–136PubMedCrossRefGoogle Scholar
  17. Harding JE (2001) The nutritional basis of the fetal origins of adult disease. Int J Epidemiol 30: 15–23PubMedCrossRefGoogle Scholar
  18. Hultman K, Alexanderson C, Manneras L, Sandberg M, Holmang A, Jansson T (2007) Maternal taurine supplementation in the late pregnant rat stimulates postnatal growth and induces obesity and insulin resistance in adult offspring. J Physiol 579:823–833PubMedCrossRefGoogle Scholar
  19. Lackland DT, Egan BM, Syddall HE, Barker DJ (2002) Associations between birth weight and antihypertensive medication in black and white medicaid recipients. Hypertension 39:179–183PubMedCrossRefGoogle Scholar
  20. Langley-Evans SC, Langley-Evans AJ, Marchand MC (2003) Nutritional programming of blood pressure and renal morphology. Arch Physiol Biochem 111:8–16PubMedCrossRefGoogle Scholar
  21. Militante JD, Lombardini JB (2002) Treatment of hypertension with oral taurine: experimental and clinical studies. Amino Acids 23:381–393PubMedCrossRefGoogle Scholar
  22. Mozaffari MS, Miyata N, Schaffer SW (2003) Effects of taurine and enalapril on kidney function of the hypertensive glucose-intolerant rat. Am J Hypertens 16:673–680PubMedCrossRefGoogle Scholar
  23. Nandhini AT, Anuradha CV (2004) Hoe 140 abolishes the blood pressure lowering effect of taurine in high fructose-fed rats. Amino Acids 26:299–303PubMedCrossRefGoogle Scholar
  24. Racasan S, Braam B, van der Giezen DM, Goldschmeding R, Boer P, Koomans HA, Joles JA (2004) Perinatal L-arginine and antioxidant supplements reduce adult blood pressure in spontaneously hypertensive rats. Hypertension 44:83–88PubMedCrossRefGoogle Scholar
  25. Rettig R, Folberth C, Kopf D, Stauss H, Unger T (1990) Role of the kidney in the pathogenesis of primary hypertension. Clin Exp Hypertens A 12:957–1002PubMedCrossRefGoogle Scholar
  26. Rettig R, Grisk O (2005) The kidney as a determinant of genetic hypertension: evidence from renal transplantation studies. Hypertension 46:463–468PubMedCrossRefGoogle Scholar
  27. Roysommuti S, Khongnakha T, Jirakulsomchok D, Wyss JM (2002) Excess dietary glucose alters renal function before increasing arterial pressure and inducing insulin resistance. Am J Hypertens 15:773–779PubMedCrossRefGoogle Scholar
  28. Roysommuti S, Malila P, Jirakulsomchok D, Jirakulsomchok S, Wyss JM (2004) Perinatal taurine status influences renal hemodynamics in adult conscious rats. FASEB J 18 (4 Part I): A292–A293Google Scholar
  29. Roysommuti S, Suvanich A, Jirakulsomchok D, Wyss JM (2007) Perinatal taurine depletion causes autonomic dysregulation in rats on a high glucose diet. FASEB J 21 (6 Part II):A887Google Scholar
  30. Sturman JA (1993) Taurine in development. Physiol Rev 73:119–147PubMedGoogle Scholar
  31. Suvanich A, Jirakulsomchok D, Muchimapura S, Wyss JM, Roysommuti S (2006) Perinatal taurine depletion impairs autonomic control in conscious rats. FASEB J 20 (5 Part II):A1406–A1407Google Scholar
  32. Tenner TE Jr, Zhang XJ, Lombardini JB (2003) Hypoglycemic effects of taurine in the alloxan-treated rabbit, a model for type 1 diabetes. Adv Exp Med Biol 526:97–104Google Scholar
  33. Zelikovic I, Chesney RW, Friedman AL, Ahlfors CE (1990) Taurine depletion in very low birth weight infants receiving prolonged total parenteral nutrition: role of renal immaturity. J Pediatr 116:301–306PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Sanya Roysommuti
    • 1
  • Wichaporn Lerdweeraphon
  • Pisamai Malila
  • Dusit Jirakulsomchok
  • J. Michael Wyss
    • 1
  1. 1.Department of Physiology Faculty of MedicineKhon Kaen UniversityThailand

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