Sex Dependent Effects of Perinatal Taurine Exposure on the Arterial Pressure Control in Adult Offspring
The present study tests the sex-dependent effect of perinatal taurine exposure on arterial pressure control in adults. Female Sprague-Dawley rats were fed normal rat chow with 3% beta-alanine (taurine depletion,TD), 3% taurine (taurine supplementation,TS) or water alone (C) from conception to weaning. Their male and female offspring were then fed normal rat chow and tap water with 5% glucose (C with glucose, CG; TD with glucose, TDG; TS with glucose, TSG) or water alone (CW, TDW or TSW). At 7–8 weeks of age, they were studied in a conscious condition. Body weights were lower in male and female TDG and male TDW rats. Kidney to body weights increased in female TSW but not TSG. Plasma sodium and potassium were not significantly different among males. Among females, plasma sodium levels were lower in all glucose treated groups while plasma potassium levels were lower only in TDG. Hematocrit, fasting blood glucose, and glucose tolerance were not significantly different between the sexes. Mean arterial pressure increased in male TDG, TSW, and TSG while in the females, mean arterial pressure increased in TDW, TDG, and TSG. Heart rates were not significantly different between the sexes. The present data indicate that perinatal taurine exposure alters arterial pressure control of adult rats and this effect is gender specific.
KeywordsFemale Offspring Taurine Supplementation Plasma Sodium Level Taurine Depletion High Sugar Diet
Unable to display preview. Download preview PDF.
- Barker DJ(2007) The origins of the developmental origins theory. J Intern Med 261:412–417Google Scholar
- Cella SG, Locatelli V, Mennini T, Zanini A, Bendotti C, Forloni GL, Fumagalli G, Arce VM, de GC, V, Wehrenberg WB, et al. (1990) Deprivation of growth hormone-releasing hormone early in the rat’s neonatal life permanently affects somatotropic function. Endocrinology 127: 1625–1634PubMedCrossRefGoogle Scholar
- Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, Gersch MS, Benner S, Sanchez-Lozada LG (2007) Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 86:899–906PubMedGoogle Scholar
- Lerdweerapol W, Jirakulsomchok D, Wyss JM, Roysommuti S (2007) Perinatal taurine supplementation influences renal hemodynamics and excretory function in adult, female rats. FASEB J 21 (5 Part I):A501–502Google Scholar
- Roysommuti S, Malila P, Jirakulsomchok D, Jirakulsomchok S, Wyss JM (2004) Perinatal taurine status influences renal hemodynamics in adult conscious rats. FASEB J 18 (4 Part I): A292–A293Google Scholar
- Roysommuti S, Suvanich A, Jirakulsomchok D, Wyss JM (2007) Perinatal taurine depletion causes autonomic dysregulation in rats on a high glucose diet. FASEB J 21 (6 Part II):A887Google Scholar
- Suvanich A, Jirakulsomchok D, Muchimapura S, Wyss JM, Roysommuti S (2006) Perinatal taurine depletion impairs autonomic control in conscious rats. FASEB J 20 (5 Part II):A1406–A1407Google Scholar
- Ventura SJ, Martin JA, Curtin SC, Mathews TJ, Park MM, Hyattsville, MD (eds) (2002) Department of Health and Human Services. National Vital Statistics Report, pp 1–100Google Scholar