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Taurine 7 pp 123-133 | Cite as

Perinatal Taurine Depletion Increases Susceptibility to Adult Sugar-Induced Hypertension in Rats

  • Sanya Roysommuti
  • Atchariya Suwanich
  • Dusit Jirakulsomchok
  • J. Michael Wyss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)

Abstract

This study tests the hypothesis that perinatal taurine depletion produces autonomic nervous system dysregulation and increases arterial pressure in young male rats maintained on a high sugar diet. Sprague-Dawley dams were either taurine depleted (beta-alanine 3% in water) or left untreated from conception to weaning. Their male offspring were fed normal rat chow with or without 5% glucose. At 7–8 weeks of age, the male offspring were either tested in a conscious, unrestrained state or after anesthetia. Body weight was slightly lower in the taurine-depleted rats although their heart or kidneys to body weight ratios were similar. Plasma potassium, blood urea nitrogen, plasma creatinine, hematocrit, fasting blood glucose concentrations and glucose tolerance were all similar. In the taurine-depleted, high glucose group, mean arterial pressure and sympathetic nervous system activity were increased while baroreflex function was impaired. These findings suggest that in this model perinatal taurine depletion causes autonomic nervous system dysfunction that may contribute to dietary high sugar-induced hypertension.

Keywords

Sympathetic Nerve Activity Taurine Supplementation Taurine Content Autonomic Nervous System Dysfunction High Glucose Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aerts L, Van Assche FA (2002) Taurine and taurine-deficiency in the perinatal period. J Perinat Med 30:281-286PubMedCrossRefGoogle Scholar
  2. Albrecht J, Schousboe A (2005) Taurine interaction with neurotransmitter receptors in the CNS: an update. Neurochem Res 30:1615–1621PubMedCrossRefGoogle Scholar
  3. Barker DJ, Eriksson JG, Forsen T, Osmond C (2002) Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol 31: 1235–1239PubMedCrossRefGoogle Scholar
  4. Barker DJ, Osmond C, Forsen TJ, Kajantie E, Eriksson JG (2007) Maternal and social origins of hypertension. Hypertension 50:565–571PubMedCrossRefGoogle Scholar
  5. Carlson SH, Roysomutti S, Peng N, Wyss JM (2001) The role of the central nervous system in NaCl-sensitive hypertension in spontaneously hypertensive rats. Am J Hypertens 14: 155S–162SPubMedCrossRefGoogle Scholar
  6. Cerutti C, Gustin MP, Paultre CZ, Lo M, Julien C, Vincent M, Sassard J (1991) Autonomic nervous system and cardiovascular variability in rats: a spectral analysis approach. Am J Physiol 261:H1292–H1299PubMedGoogle Scholar
  7. Chesney RW, Helms RA, Christensen M, Budreau AM, Han X, Sturman JA (1998) The role of taurine in infant nutrition. Adv Exp Med Biol 442:463–476PubMedGoogle Scholar
  8. Dawson R, Jr., Eppler B, Patterson TA, Shih D, Liu S (1996) The effects of taurine in a rodent model of aging. Adv Exp Med Biol 403:37–50PubMedGoogle Scholar
  9. DiBona GF, Jones SY (2003) Endogenous angiotensin affects responses to stimulation of baroreceptor afferent nerves. J Hypertens 21:1539–1546PubMedCrossRefGoogle Scholar
  10. Eriksson JG, Forsen TJ, Kajantie E, Osmond C, Barker DJ (2007) Childhood growth and hypertension in later life. Hypertension 49:1415–1421PubMedCrossRefGoogle Scholar
  11. Forrester T (2004) Historic and early life origins of hypertension in Africans. J Nutr 134:211–216PubMedGoogle Scholar
  12. Gao L, Wang W, Li YL, Schultz HD, Liu D, Cornish KG, Zucker IH (2005) Sympathoexcitation by central ANG II: roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLM. Am J Physiol Heart Circ Physiol 288:H2271–H2279PubMedCrossRefGoogle Scholar
  13. Hanson M, Gluckman P, Bier D, Challis J, Fleming T, Forrester T, Godfrey K, Nestel P, Yajnik C (2004) Report on the 2nd World Congress on Fetal Origins of Adult Disease, Brighton, U.K., June 7-10, 2003. Pediatr Res 55:894–897PubMedCrossRefGoogle Scholar
  14. Harding JE (2001) The nutritional basis of the fetal origins of adult disease. Int J Epidemiol 30: 15–23PubMedCrossRefGoogle Scholar
  15. Inoue A, Takahashi H, Lee LC, Iyoda I, Sasaki S, Okajima H, Takeda K, Yoshimura M, Nakagawa M, Ijichi H (1985) Centrally induced vasodepressor and sympathetic nerve responses to taurine. Jpn Circ J 49:1180–1184PubMedGoogle Scholar
  16. Johns EJ (2005) Angiotensin II in the brain and the autonomic control of the kidney. Exp Physiol 90:163–168PubMedCrossRefGoogle Scholar
  17. Kohlenbach A, Schlicker E (1990) GABAB receptor-mediated inhibition of the neurogenic vasopressor response in the pithed rat. Br J Pharmacol 100:365–369PubMedGoogle Scholar
  18. Langley-Evans SC (2006) Developmental programming of health and disease. Proc Nutr Soc 65:97–105PubMedCrossRefGoogle Scholar
  19. Law CM, Egger P, Dada O, Delgado H, Kylberg E, Lavin P, Tang GH, von Hertzen H, Shiell AW, Barker DJ (2001) Body size at birth and blood pressure among children in developing countries. Int J Epidemiol 30:52–57PubMedCrossRefGoogle Scholar
  20. Lourenco R, Camilo ME (2002) Taurine: a conditionally essential amino acid in humans? An overview in health and disease. Nutr Hosp 17:262–270PubMedGoogle Scholar
  21. McMullan S, Goodchild AK, Pilowsky PM (2007) Circulating angiotensin II attenuates the sympathetic baroreflex by reducing the barosensitivity of medullary cardiovascular neurones in the rat. J Physiol 582:711–722PubMedCrossRefGoogle Scholar
  22. Melancon S, Bachelard H, Badeau M, Bourgoin F, Pitre M, Lariviere R, Nadeau A (2006) Effects of high-sucrose feeding on insulin resistance and hemodynamic responses to insulin in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 290:H2571–H2581PubMedCrossRefGoogle Scholar
  23. Mendez MA, Wynter S, Wilks R, Forrester T (2004) Under- and overreporting of energy is related to obesity, lifestyle factors and food group intakes in Jamaican adults. Public Health Nutr 7: 9–19PubMedCrossRefGoogle Scholar
  24. Militante JD, Lombardini JB (2002) Treatment of hypertension with oral taurine: experimental and clinical studies. Amino Acids 23:381–393PubMedCrossRefGoogle Scholar
  25. Mizushima S, Nara Y, Sawamura M, Yamori Y (1996) Effects of oral taurine supplementation on lipids and sympathetic nerve tone. Adv Exp Med Biol 403:615–622PubMedGoogle Scholar
  26. Pacioretty L, Hickman MA, Morris JG, Rogers QR (2001) Kinetics of taurine depletion and repletion in plasma, serum, whole blood and skeletal muscle in cats. Amino Acids 21:417–427PubMedCrossRefGoogle Scholar
  27. Pladys P, Lahaie I, Cambonie G, Thibault G, Le NL, Abran D, Nuyt AM (2004) Role of brain and peripheral angiotensin II in hypertension and altered arterial baroreflex programmed during fetal life in rat. Pediatr Res 55:1042–1049PubMedCrossRefGoogle Scholar
  28. Racasan S, Braam B, van der Giezen DM, Goldschmeding R, Boer P, Koomans HA, Joles JA (2004) Perinatal L-arginine and antioxidant supplements reduce adult blood pressure in spontaneously hypertensive rats. Hypertension 44:83–88PubMedCrossRefGoogle Scholar
  29. Reaven GM (1990) Insulin and hypertension. Clin Exp Hypertens A 12:803–816PubMedCrossRefGoogle Scholar
  30. Reaven GM (1991) Insulin resistance, hyperinsulinemia, and hypertriglyceridemia in the etiology and clinical course of hypertension. Am J Med 90:7S–12SPubMedCrossRefGoogle Scholar
  31. Riviere G, Michaud A, Breton C, VanCamp G, Laborie C, Enache M, Lesage J, Deloof S, Corvol P, Vieau D (2005) Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat. Hypertension 46:1169–1174PubMedCrossRefGoogle Scholar
  32. Roysommuti S, Khongnakha T, Jirakulsomchok D, Wyss JM (2002) Excess dietary glucose alters renal function before increasing arterial pressure and inducing insulin resistance. Am J Hypertens 15:773–779PubMedCrossRefGoogle Scholar
  33. Roysommuti S, Malila P, Jirakulsomchok D, Jirakulsomchok S, Wyss JM (2004) Perinatal taurine status influences renal hemodynamics in adult conscious rats. FASEB J 18 (4 Part I):A292–A293Google Scholar
  34. Sato Y, Ando K, Fujita T (1987) Role of sympathetic nervous system in hypotensive action of taurine in DOCA-salt rats. Hypertension 9:81–87PubMedGoogle Scholar
  35. Schaffer S, Azuma J, Takahashi K, Mozaffari M (2003) Why is taurine cytoprotective? Adv Exp Med Biol 526:307–321PubMedGoogle Scholar
  36. Shiell AW, Campbell-Brown M, Haselden S, Robinson S, Godfrey KM, Barker DJ (2001) High-meat, low-carbohydrate diet in pregnancy: relation to adult blood pressure in the offspring. Hypertension 38:1282–1288PubMedCrossRefGoogle Scholar
  37. Shimamoto K, Ura N (2006) Mechanisms of insulin resistance in hypertensive rats. Clin Exp Hypertens 28:543–552PubMedCrossRefGoogle Scholar
  38. Stauss HM, Kregel KC (1996) Frequency response characteristic of sympathetic-mediated vasomotor waves in conscious rats. Am J Physiol 271:H1416–H1422PubMedGoogle Scholar
  39. Sturman JA (1993) Taurine in development. Physiol Rev 73:119–147PubMedGoogle Scholar
  40. Wyss JM, Roysommuti S, King K, Kadisha I, Regan CP, Berecek KH (1994) Salt-induced hypertension in normotensive spontaneously hypertensive rats. Hypertension 23:791–796PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Sanya Roysommuti
    • 1
  • Atchariya Suwanich
  • Dusit Jirakulsomchok
  • J. Michael Wyss
  1. 1.Department of Physiology Faculty of MedicineKhon Kaen UniversityThailand

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