Taurine 7 pp 113-122 | Cite as

TauT Protects Against Cisplatin-Induced Acute Kidney Injury (AKI) Established in a TauT Transgenic Mice Model

  • Xiaobin Han
  • Russell W. Chesney
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)


Cisplatin is a commonly used chemotherapeutic agent that has a major limitation because of its nephrotoxicity. Taurine is an important osmolyte that has been found to protect against cisplatin-induced apoptosis in renal cells in vitro. To determine whether over-expression of hTauT protects against cisplatin-induced acute kidney injury (AKI) in vivo, animals (wt and transgenic) were injected with cisplatin and the levels of BUN and serum creatinine were measured. Saline-injected mice were used as a control. The results showed that the levels of BUN and creatinine were significantly increased in the cisplatin-injected wild-type mice (110 ± 12 mg/dl and 0.98 ± 0.05 mg/dl) as compared to the saline-injected wild type mice (20 ± 2.5 mg/dl and 0.52 ± 0.06 mg/dl). However, over-expression of hTauT effectively prevented the progression of cisplatin-induced AKI in hTauT transgenic mice, as measured by the levels of BUN and serum creatininelevels (23 ± 3.5 mg/dl and 0.6 ± 0.05 mg/dl).


Acute Renal Failure Blood Urea Nitrogen Acute Kidney Injury Taurine Transporter Renal Proximal Tubular Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Xiaobin Han
    • 1
  • Russell W. Chesney
  1. 1.Department of PediatricsUniversity of Tennessee Health Science Center and the Children’s Foundation Research Center at Le Bonheur Children’s Medical CenterMemphisUSA

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